Giant Cell Tumor of the Lateral Skull Base: Diagnostic and Management Options

Abstract

Giant cell tumor of bone (GCTB) is a rare, benign, osteolytic neoplasm that most commonly occurs in early adulthood and often involves the long bones of the body. Although GCTB largely affects the epiphyses of long bones, several reports of GCTB involvement of the cranial and facial bones exist in the literature. In addition to reviewing other reported cases of GCTBs of the lateral skull base in the literature, the authors report here on the clinical presentation, radiographic findings, and neurosurgical management of a patient found to have a GCTB of the middle and infratemporal fossae, which was treated by aggressive en bloc resection of the lateral skull base.

Dosing interval adjustment of denosumab for the treatment of giant cell tumor of the sphenoid bone: A case report

“…Even worse, the possibility of radiation-induced malignant transformation of GCTB has also been conjectured. [ 4 , 6 ]…”

“…[ 15 ] Furthermore, hematogenous metastasis to the lung or malignant transformation may occur in some patients. [ 4 , 6 , 16 ]…”

Hemorrhagic Giant Cell Tumor of the Occipital Skull Base: A Case Report and Literature Review

“…Only 0.7% to 1% of GCTB cases originate in the skull; of these, the majority arise from sphenoid or temporal bone [2][3][4][5][6]. The preference for the sphenoid and petrous temporal bone is thought to relate to the endochondral histogenesis of these tumors, in contrast to the intramembranous ossification of the other cranial bones [7,8]. The occurrence of GCTB skull-based tumors in pre-pubertal individuals is also quite rare, as GCTB incidence peaks in adults during their third to fourth decades of life, more frequently in females [1,2,8,9].…”

“…Here we present the case of a nine-year-old girl who presented with a GCTB of the posterior fossa. We review her presenting symptoms, imaging features, treatment, and tumor histopathology, as well as the relevant literature of these rare tumors [2,[5][6][7][9][10][11][12][13][14]. This is the third known literature report of an occipital GCTB in a pediatric patient with GCTB [9].…”

“…[2,[5][6][7][9][10][11][12][13][14]. There were six females and three males whose ages ranged from eight to 53 years, with a mean of 21.6 years.…”