Giant Cell Tumor of Uterus Resembling Osseous Giant Cell Tumor

Manglik, Niti; Sawicki, Janusz; Saad, Andre; Fadare, Oluwole; Soslow, Robert A.; Liang, Sharon X.

doi:10.1177/1066896912436554

Cited by 6 publications

(2 citation statements)

References 15 publications

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“…These cases require detailed immunohistochemistry. 12,13 The tumor is considered epithelial if the background cells stain positive to keratin (Cytokeratin AE1/AE3) or epithelial membrane antigen and when they are positive for mesenchymal markers (h-caldesmon, myogenin or DOG1), the tumor is categorized as mesenchymal. 8 In this present case, stain were negative for all markers, except for those with histiocytic differentiation (CD68), being more consistent with the diagnosis of a malignant giant cell tumor.…”

Section: Pathologymentioning

confidence: 99%

Malignant giant cell tumor of the uterus: a case report

Oliveira¹,

Stecca²,

Silva³

et al. 2021

Brazilian Journal of Oncology

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This report describes a rare case of malignant extraosseous giant cell tumor (GCT). It refers to a patient with an initial diagnosis of a locally advanced malignant GCT of the uterus, with disease progression to lung and mediastinum seven months after the diagnosis, requiring first line treatment with chemotherapy. Extraosseous presentation of GCT with early distant dissemination is unusual and the role of systemic cytotoxic treatment remains unclear.

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Section: Pathologymentioning

confidence: 99%

Malignant giant cell tumor of the uterus: a case report

Oliveira¹,

Stecca²,

Silva³

et al. 2021

Brazilian Journal of Oncology

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“…In tumors of the human uterus, GC infiltration has been reported in both endometrial and mesenchymal tumors, especially leiomyosarcomas, in tumors arising in the human uterus [ 2 , 9 , 10 , 11 , 14 , 22 , 24 ]. Infiltrated OLMGCs are sometimes observed in human uterine leiomyosarcoma with intralesional mineralization and in tumor tissues without calcium deposition [ 10 ]. In our case, calcareous deposition was not observed, not even in necrotic foci.…”

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confidence: 99%

Feline uterine carcinosarcoma infiltrated with osteoclast-like giant cells

Murakami

Yonemaru

Goto

et al. 2022

The Journal of Veterinary Medical Science

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A 12-year-old female Himalayan cat underwent an ovariohysterectomy to remove an intraabdominal mass. Histologic examination using immunohistochemical staining revealed that the mass was comprised of epithelial and mesenchymal components. Within the lesion, multinucleated giant cells (MGCs) were observed diffusely. MGCs were positive for vimentin and Iba-1 and negative for cytokeratin AE1/AE3 and CD204. In addition, MGCs were negative for Ki-67, indicating nonneoplastic cells. Osteoclast-like MGC (OLMGC) phenotype with tartrate-resistant acid phosphatase positivity was also seen. These findings suggested that the uterine tumor was carcinosarcoma with OLMGCs. Uterine tumors in humans, such as leiomyosarcoma and carcinosarcoma, with OLMGC infiltration are well-known pathologic entities; however, they are rare in animals and to our knowledge, have not been previously reported in cats.

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Giant Cell Tumor of the Uterus

Bennett

Sanada

Selig

et al. 2015

International Journal of Gynecological Pathology

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Giant cell tumors, a well-recognized neoplasm of bone, can rarely be found in the uterus. Such tumors are characterized by a dual population of mononuclear and osteoclast-like giant cells that lack epithelial and specific mesenchymal differentiation. In this study, the clinicopathologic features of 3 giant cell tumors of the uterus were reviewed. Immunohistochemistry for CD68, CD163, h-caldesmon, desmin, SMA, AE1/AE3, CD10, ER, PR, cyclin D1, CD1a, CD34, CD30, S100, myogenin/myoglobin, and Ki-67 was performed in all tumors, along with ultrastructural analysis in one. The patients were 47, 57, and 59 yr and the tumors measured 2.5, 7.5, and 16.0 cm. One neoplasm was confined to the endometrium, whereas the other 2 were myometrial. All 3 tumors showed a nodular growth comprised of mononuclear and osteoclast-like giant cells. The endometrial-confined tumor consisted of histologically benign mononuclear cells, whereas the others exhibited marked atypia. Mitotic activity was up to 5/10 HPF in the benign tumor and up to 22/10 HPF in the malignant. No cytologic atypia or mitoses were observed in the giant cells. CD68 and CD10 were strongly and diffusely expressed in both components of 3 and 2 neoplasms, respectively. Cyclin D1 was focal in the mononuclear cells and focal to diffuse in the giant cells. CD163 was diffuse in the mononuclear cells, but absent to focal in the giant cells. Ultrastructural analysis lacked diagnostic features of epithelial or specific mesenchymal differentiation. Both malignant tumors demonstrated an aggressive behavior. In summary, although rare, giant cell tumor of the uterus should be included in the differential diagnosis of benign or malignant tumors containing osteoclast-like giant cells.

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Giant Cell Tumor of Uterus Resembling Osseous Giant Cell Tumor

Cited by 6 publications

References 15 publications

Malignant giant cell tumor of the uterus: a case report

Malignant giant cell tumor of the uterus: a case report

Feline uterine carcinosarcoma infiltrated with osteoclast-like giant cells

Giant Cell Tumor of the Uterus

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