Giant cell tumour of bone with pulmonary metastases

Giant cell tumor of bone: treatment and outcome of 214 cases

“…The rate of pulmonary metastasis in our collective counts 3.3% and is in accordance with previous reports (Bertoni et al 1985(Bertoni et al , 1988Cheng and Johnston 1997;Goldenberg et al 1970;Kay et al 1994;Masui et al 1998;Osaka et al 1997;Rock et al 1984;Sanjay and Kadhi 1998;Siebenrock et al 1998;Tubbs et al 1992). Interestingly the gender distribution is contrary to non-metastasizing tumors.…”

“…The literature indicates that local recurrence is accompanied by an increased risk of pulmonary metastases (Bertoni et al 1985;Cheng and Johnston 1997;Kay et al 1994;Lausten et al 1996;Masui et al 1998;Rock et al 1984;Sanjay and Kadhi 1998;Tubbs et al 1992). This can be supported by our data because all cases of metastases appeared after local recurrence.…”

“…Although the prognosis after surgical removal of the metastases is usually good (Sanjay and Kadhi 1998;Siebenrock et al 1998;Tubbs et al 1992) the individual course remains unpredictable. In some cases patients may die due to metastasizing GCTB (Leichtle et al 2006;Siebenrock et al 1998) as it happened to one of our patients.…”

“…Local recurrence is accompanied by an increased risk of so called 'benign' pulmonary metastases (Bertoni et al 1985;Bertoni et al 1988;Campanacci et al 1987;Cheng and Johnston 1997;Dominkus et al 2006;Goldenberg et al 1970;Kay et al 1994;Maloney et al 1989;McDonald et al 1986;Osaka et al 1997;Rock et al 1984;Sanjay and Kadhi 1998;Siebenrock et al 1998;Tubbs et al 1992).…”

Giant cell tumor of the uterus: case report and response to chemotherapy

“…Pulmonary metastases of GCT of bone usually grow slowly, and are often treated by surgery, though in some cases chemotherapy with various agents or radiation therapy have been used [30][31][32][33][34][35][36][37][38][39]. Two cases of rapidly progressive metastatic GCT of bone have been reported that were treated with chemotherapy with a transient response [40,41].…”