Giant-cell tumour of bone: cytological studies

Kasahara, Keiko; Yamamuro, Takao; Kasahara, Akinori

doi:10.1038/bjc.1979.167

Cited by 22 publications

(7 citation statements)

References 29 publications

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“…The presence of macrophage‐like cells in the mononuclear component of GCTB and GCRG of the jaw has previously been established by cytochemical 20, immunohistochemical 16, 17, 19, 21, 22, and ultrastructural 13, 23, 24 studies. These cells form a reactive rather than a neoplastic component of the tumour and are commonly associated with areas of haemorrhage found within these lesions.…”

Section: Discussionmentioning

confidence: 98%

Phenotypic characterization of mononuclear and multinucleated cells of giant cell reparative granuloma of small bones

Itonaga

Schulze

Burge

et al. 2002

The Journal of Pathology

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Four cases of giant cell reparative granuloma (GCRG) of small bones were analysed in order to determine the pathogenesis of the lesion and the nature of the component mononuclear and multinucleated cells. In cell cultures, giant cells formed a non-proliferating homogeneous population which expressed features characteristic of the osteoclast phenotype, including leucocyte common antigen, CD68, vitronectin receptor, and tartrate-resistant acid phosphatase. The giant cells were capable of lacunar resorption and their activity was inhibited by calcitonin. In addition to numerous macrophage-like cells, some of which expressed osteoclast phenotypic characteristics, there were also mononuclear stromal cells which proliferated in culture and were alkaline phosphatase-positive; these cells expressed receptor activator of NF-kappaB ligand (RANKL) and were capable of supporting human osteoclast formation from circulating precursors in vitro. These findings suggest that the osteoclast-like giant cells in GCRG of small bones are formed from monocyte/macrophage-like osteoclast precursors which differentiate into osteoclasts under the influence of mononuclear osteoblast-like stromal cells.

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Section: Discussionmentioning

confidence: 98%

Phenotypic characterization of mononuclear and multinucleated cells of giant cell reparative granuloma of small bones

Itonaga

Schulze

Burge

et al. 2002

The Journal of Pathology

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“…4 The cytological features of GCT were first described by Sanerkin and Jeffree 10 on scrapings from surgical specimens.…”

Section: Discussionmentioning

confidence: 99%

“…The tumor consists of mononucleated mesenchymal cells and giant cells. 4 Other giant cell-rich lesions, both benign and malignant, that are considered in the differential diagnosis are aneurysmal bone cyst (ABC), chondroblastoma, GCTTS, metaphyseal fibrous defect (MFD), and osteogenic sarcoma. Giant-cell tumor of tendon sheath, one among many synonyms for the localized form of nodular tenosynovitis, is thought to arise from the synovium of the tendon sheath of hands and feet.…”

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confidence: 99%

Comparison of cytologic features of giant‐cell tumor and giant‐cell tumor of tendon sheath

Gupta

Dey

Goldsmith

et al. 2003

Diagnostic Cytopathology

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The cytologic features in twelve cases of giant-cell tumor (GCT) and five cases of giant-cell tumor of tendon sheath (GCTTS) diagnosed by fine-needle aspiration cytology (FNAC) are described. All of these cases were histopathologically confirmed. The aspirates of GCT are composed of a dual population of mononucleated spindle cell and multinucleated giant cells. The peripheral adherence of giant cells to the spindle cell is the feature of diagnostic significance in GCT. In GCTTS, the aspirate consists of a polymorphic population composed of mononuclear histiocyte-like cells, hemosiderin laden macrophages, foamy macrophages, and a few multinucleated giant cells. FNAC can be used as a diagnostic tool for an early and accurate detection of these two giant cell-rich lesions, since the cytologic features when evaluated in conjunction with the clinical and radiologic features are sufficiently diagnostic.

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“…As described above, the histological and clinical criteria for malignancy of BGCT are quite ambiguous and controversial, and their validity is confusing in the diagnosis [17,24,26,33]. In order to solve the problem, many histochemical and biochemical methods have been applied to the lesions in search of reliable markers of malignancy.…”

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confidence: 99%

Demonstration of Biological Aggressiveness of Bone Giant Cell Tumor by the Comparative Study of Immunohistochemical Detection of DNA-instability and Cortical Bone Destruction by CT.

Azuchi

Baba

Imura

et al. 1998

Acta Histochem. Cytochem

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The degree of DNA-instability as revealed by the immunohistochemical staining with anti-single-stranded DNA antibody after acid hydrolysis (DNA-instability test) was used as a marker of malignancy. This was applied to benign (4 osteochondroma and 4 enchondroma cases), border-line (23 bone giant cell tumor, BGCT cases), and malignant (6 chondrosarcoma and 6 osteosarcoma cases) neoplastic lesions. The expression of tumor oncogene, c-myc was detected immunohistochemically.Proliferative activity was evaluated by PCNA-immunohistochemistry, and the quantitative analysis of the number, mean area, mean total area, the largest area, and maximum shape-irregularity of AgNORs in a nucleus were performed for all these cases. The results for 19 BGCT (82.6%) cases, 6 chondrosarcoma cases (100%), and 6 osteosarcoma cases (100%) were positive with the DNA-instability test, indicating their malignancy. All benign tumor cases were negative with the DNA-instability test.Reflecting the malignant character, all chondrosarcoma cases, all osteosarcoma cases and the BGCT cases positive with the DNA-instability test showed statistically higher values of PCNA-index; and all AgNORsparameters in comparison to those for benign tumor cases, and c-myc was positive for 66.7%, and 26.3%, of them, respectively. But these values for BGCT with positive and negative DNA-instability test results showed no statistically meaningful differences. All the BGCT cases negative with DNA-instability test were negative for cmyc expression.Among the BGCT cases positive with DNA-instability test, 18 cases (94.7%) showed cortical bone destruction by computed tomography (CT), and 5 cases (26.3%) showed extra-osseous expansion. No such radiographic changes were detected among the BGCT cases negative with DNAinstability test. Among 18 BGCT cases with cortical bone destruction, 5 cases (27.8%) showed tumor recurrences, and 2 cases (11.1 %) showed lung metastases.These results indicate that the majority of BGCT cases are malignant and the detection of cortical bone destruction by CT is a sensitive clinical marker to detect them.

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Giant-cell tumour of bone: cytological studies

Cited by 22 publications

References 29 publications

Phenotypic characterization of mononuclear and multinucleated cells of giant cell reparative granuloma of small bones

Phenotypic characterization of mononuclear and multinucleated cells of giant cell reparative granuloma of small bones

Comparison of cytologic features of giant‐cell tumor and giant‐cell tumor of tendon sheath

Demonstration of Biological Aggressiveness of Bone Giant Cell Tumor by the Comparative Study of Immunohistochemical Detection of DNA-instability and Cortical Bone Destruction by CT.

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