Giant cell tumor of soft tissue (GCT-ST) is a rare tumor of low malignant potential. Grossly and histologically similar to its bone counterpart. Majority has benign clinical course and rarely metastasizes. This is a case of a 46-year-old woman with a giant cell tumor of soft tissue of the knee. This tumor was not suspected clinically and was initially diagnosed as septic infra-patellar bursitis. The diagnosis of GCT-ST was made after histopathological examination. Herein, we describe the clinical, histologic, and immunohistochemical features of this rare neoplasm.