Giant cellular blue nevus of the anterior chest wall mimicking metastatic melanoma to the breast: A case report

Hoos, Axel; Berho, Mariana; Blumencranz, Peter W.; Brady, Mary S.

doi:10.1002/1096-9098(200008)74:4<278::aid-jso7>3.0.co;2-d

Cited by 11 publications

(4 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These cases are reported in the literature as ''melanotic carcinoma,'' [22][23][24][25] pigmented mammary Paget disease, 26,27 and blue nevi of the mammary gland proper. 28 Some cases with pigments are merely breast carcinomas that have phagocytized melanin from the adjacent skin. 21 Nonetheless, the differential diagnosis of MM to the breast is a rather complex task.…”

Section: Commentmentioning

confidence: 99%

Metastatic Melanoma Presenting as an Isolated Breast Tumor: A Study of 20 Cases With Emphasis on Several Primary Mimickers

Bacchi

Wludarski²,

Ambaye³

et al. 2013

Archives of Pathology &Amp; Laboratory Medicine

View full text Add to dashboard Cite

Metastatic melanoma may simulate a broad spectrum of primary breast malignancies. Although the application of a simple panel of antibodies assists in rendering the correct interpretation, lesions presenting as isolated breast tumors may introduce a significant diagnostic difficulty, especially when there is inadequate patient history and/or limited biopsy material. Further challenges are introduced by the extraordinary phenotypic plasticity of metastatic melanoma. Awareness of this pattern variance is essential to avoid inappropriate treatment, especially in cases simulating a "triple negative," poorly differentiated carcinoma of the breast.

show abstract

Section: Commentmentioning

confidence: 99%

Metastatic Melanoma Presenting as an Isolated Breast Tumor: A Study of 20 Cases With Emphasis on Several Primary Mimickers

Bacchi

Wludarski²,

Ambaye³

et al. 2013

Archives of Pathology &Amp; Laboratory Medicine

View full text Add to dashboard Cite

show abstract

“…Giant cellular blue nevus (GCBN) has been described in extra-genital sites, such as the chest wall [5]. However, GCBN of the vagina has not been described previously.…”

Section: Discussionmentioning

confidence: 99%

“…Only a few cases of giant cellular blue nevus (greater than 5 cm) have been reported [4,5]. The angiomatoid cellular blue nevus is a variant of blue nevus that is rarely reported in the literature [6].…”

Section: Introductionmentioning

confidence: 99%

Angiomatoid giant cellular blue nevus of vaginal wall associated with pregnancy

Al‐Shraim

2011

Diagn Pathol

View full text Add to dashboard Cite

BackgroundBlue nevi that arise from the Müllerian tract are rare melanocytic lesions. Several histopathologic variants of cellular blue nevi have been described. The angiomatoid variant is characterized by a vascular component, and is considered to be a rare variant. Few studies have explored the influence of pregnancy on melanocytic lesions.CaseA 29-year-old woman was presented with a pigmented vaginal lesion that increased gradually during pregnancy. A full term gynecologic examination showed a tumor mass protruding into the vaginal canal. The mass was resected during cesarean-section under the clinical impression of vaginal hemangioma.ResultGross examination revealed a cystic mass measuring 6.0 × 4.3 × 3.5 cm, which was filled with dark friable material. Histologically, the mass showed a subepithelial cellular proliferation of heavily pigmented dendritic melanocytes with prominent vascular stroma. Cytologic pleomorphism, junctional activity, atypical mitosis, and necrosis were not found. The proliferation was immunoreactive for HMB-45, S-100 and melan-A, and non-immunoreactive for CD34, smooth muscle actin, and AE1/AE3. The MIB-1 proliferative index was less than 1%. The patient had a postoperative course without complication.ConclusionsAngiomatoid giant cellular blue nevus arising from the vagina during pregnancy is extremely rare. The low proliferative index and absence of cytologic pleomorphism, or necrosis, supports a benign biological behavior. Clinical follow-up showed no evidence of recurrence at one year after the resection of the mass.

show abstract

“…[2][3][4][5] The GCBN can be locally aggressive and may infiltrate subjacent structures, although it results in no malignant transformation. [3][4][5][6][7][8][9][10] Here, we present a case of facial GCBN that infiltrated deep structures.…”

mentioning

confidence: 99%

Infiltrating giant cellular blue naevus

Bittencourt

Monteiro²,

Pretto³

2007

J Clin Pathol

View full text Add to dashboard Cite

Introduction:Cellular blue naevi (CBN) measure 1–2 cm in diameter and affect the dermis, occasionally extending into the subcutaneous fat. The case of a 14-year-old boy with a giant CBN (GCBN) involving the right half of the face, the jugal mucosa and the lower eyelid with a tumour that had infiltrated the bone and the maxillary and ethmoidal sinuses is reported.Methods:Biopsies were taken from the skin, jugal mucosa and maxillary sinus. The following markers were used in the immunohistochemical evaluation: CD34, CD56, HMB-45, anti-S100, A-103, Melan A and MIB-1.Results:The biopsy specimens showed a biphasic pattern affecting the lower dermis, subcutaneous fat, skeletal muscle, bone, jugal mucosa and maxillary sinus, but there was no histological evidence of malignancy. The tumour cells were CD34−, CD56−, HMB45+, anti-S100+ and A-103+. Melan A was focally expressed. No positive MIB-1 cells were identified.Discussion:The present case shows that GCBN may infiltrate deeply, with no evidence of malignancy.

show abstract

Giant cellular blue nevus of the anterior chest wall mimicking metastatic melanoma to the breast: A case report

Cited by 11 publications

References 14 publications

Metastatic Melanoma Presenting as an Isolated Breast Tumor: A Study of 20 Cases With Emphasis on Several Primary Mimickers

Metastatic Melanoma Presenting as an Isolated Breast Tumor: A Study of 20 Cases With Emphasis on Several Primary Mimickers

Angiomatoid giant cellular blue nevus of vaginal wall associated with pregnancy

Infiltrating giant cellular blue naevus

Contact Info

Product

Resources

About