Giant Chondroma of the Saddle Area: Case Report and Literature Review*

Qiu, Lubin; Zhu, Yongjun; Wang, Haijun; Wang, Yatang; Wu, Qiang; Yang, Jianming

doi:10.3109/01658107.2013.830626

Cited by 5 publications

(3 citation statements)

References 38 publications

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“…To avoid serious postoperative complications, a subtotal or partial resection can be performed to alleviate clinical symptoms. 16 The tumor in the present case showed attachments to the brainstem, hypothalamus, and premammillary artery. It was decided to limit the procedure to subtotal or partial excision and then to consider a second-stage surgery if the findings showed high malignancy.…”

Section: Discussionsupporting

confidence: 47%

Giant skull base periosteal chondroma treated with endonasal endoscopic surgery: illustrative case

Nakase,

Nishimura,

Kakutani

et al. 2024

Journal of Neurosurgery: Case Lessons

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BACKGROUND Intracranial chondroma is an extremely rare type of tumor composed of mature hyaline cartilaginous tissues. No previous cases of skull base periosteal chondroma have been presented. OBSERVATIONS A 31-year-old male had progressive memory loss and diminished motivation for the previous 1.5 years. Magnetic resonance imaging revealed a giant tumor with partial calcification arising from the upper clivus and extending to the prepontine cistern. Compression of the brainstem and hypothalamus was significant. Surgery was performed and intentionally limited to an intracapsular resection with endoscopic endonasal surgery (EES), and the brainstem and hypothalamus were successfully decompressed. Pathological examination findings showed a composition of hyaline cartilage with chondrocyte clusters. Genetic testing with next-generation sequencing indicated alternations in IDH1 R132C, KDR Q472H, IDH2 I142L, and TP53 P72R. On the basis of these findings, a diagnosis of periosteal chondroma was made. Postoperatively, complete relief from all symptoms was noted, and MRI one year later showed no evidence of tumor regrowth. LESSONS This is the first known report of skull base periosteal chondroma. Genetic testing was useful for confirming the diagnosis, and EES was effective for treatment. Should such a tumor show adhesion to an important structure, an intracapsular excision can be beneficial for avoiding complications.

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Section: Discussionsupporting

confidence: 47%

Giant skull base periosteal chondroma treated with endonasal endoscopic surgery: illustrative case

Nakase,

Nishimura,

Kakutani

et al. 2024

Journal of Neurosurgery: Case Lessons

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“…The tumor compresses or encompasses the blood vessels and nerves at the base of the skull, so the difficulty and risk of total tumor resection have increased remarkably. To avoid serious postoperative complications, the tumor can be subtotally or partially removed to alleviate clinical symptoms ( 30 ).…”

Section: Discussionmentioning

confidence: 99%

Surgical Strategies and Outcomes for Intracranial Chondromas: A Retrospective Study of 17 Cases and Systematic Review

Liu

Cai

et al. 2022

Front. Oncol.

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ObjectiveTo improve the diagnosis and treatment of intracranial chondromas (ICDs) by discussing the clinical manifestations and imaging characteristics of ICDs, as well as surgical methods and treatment strategies.MethodsWe retrospectively analyzed 17 patients diagnosed with ICDs who underwent microsurgery or endoscopic transsphenoidal surgery at the Tangdu Hospital of Air Force Military Medical University and the Mianyang Central Hospital from January 2010 to November 2021. Clinical manifestations, imaging examinations, surgical treatments, and prognosis of these patients were analyzed.ResultsICDs had often been misdiagnosed as craniopharyngioma, chordoma, schwannoma, cavernous hemangioma, pituitary adenoma, and meningioma before surgery. Of the 17 cases, gross total resection (GTR) was performed in 10 cases, subtotal resection (STR) in 5, and partial resection in 2. GTR of tumor was achieved in eight cases via the endoscopic endonasal transsphenoidal approach (EETA) or the extended endoscopic endonasal transsphenoidal approach (EEETA), and the remaining patients underwent craniotomies. Clinical symptoms were assessed 1 week after surgery, 10 cases were relieved at varying degrees, and four cases had no improvement. Postoperative complications included right-limb hemiparesis, diplopia, eyelid ptosis, pulmonary infection, subcutaneous hydrops, cerebrospinal-fluid leakage (CSFL), and intracranial infection (ICI). One patient received gamma knife treatment at 3 months after surgery, two patients died due to tumor progression, and the remaining patients had no tumor recurrence.ConclusionsICDs lack typical imaging features and are often misdiagnosed. The EETA or EEETA helps improve the surgical outcomes and GTR rates of ICDs at different sites.

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“…In terms of the typical imaging features of tumors in the sellar region, tumors in the sellar region are mainly located in or above the sellar, and multiaxial scanning is easy to locate and characterize. [7][8][9] For example, the presence and absence of an intrasellar pituitary gland can help distinguish suprasellar and intrasellar tumors, i. e. pituitary tumors. 10,11 However, suprasellar tumors often invade into the sellar and compress the pituitary to move backward, and the imaging appearance is crescent.…”

Section: Discussionmentioning

confidence: 99%

Application of MRI images based on Spatial Fuzzy Clustering Algorithm guided by Neuroendoscopy in the treatment of Tumors in the Saddle Region

Zhang¹,

Zhang²,

Zhao

2021

Pak J Med Sci

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Objective: The paper applies spatial fuzzy clustering algorithm to explore the role and value of neuroendoscopic assisted technology in the operation of tumors in the saddle region, and analyze the MRI image characteristics of tumors in the saddle region. Methods: The clinical data of 63 patients from our hospital who underwent neuroendoscopic assisted microscopy to remove tumors in the saddle area from 2017 to 2019 (neuroendoscopy-assisted group) were collected. Seventy six patients who occupied the saddle area by microscopic resection only in the same period (Simple microscope group) clinical data. By comparing the patient’s tumor resection rate, postoperative complication rate and postoperative recurrence rate, the surgical effect was evaluated. Results: The total resection rates of the tumors in the neuroendoscopy-assisted group and the microscope-only group were 95.24% (60/63) and 80.26% (61/76). The incidence of postoperative vasospasm was 3.17% (2/63) and 13.16% (10/76), the incidence of nerve injury was 0 (0/63) and 6.58% (5/76), the difference was statistically significant (P <0.05). There was no significant difference in the incidence of postoperative infection, cerebrospinal fluid leakage and postoperative recurrence rate between the two groups (P> 0.05). Conclusion: Neuroendoscopy-assisted microscopy-based removal of the saddle area occupying space based on spatial fuzzy clustering algorithm can increase the total tumor resection rate and reduce the incidence of complications. doi: https://doi.org/10.12669/pjms.37.6-WIT.4850 How to cite this:Zhang P, Zhang L, Zhao R. Application of MRI images based on Spatial Fuzzy Clustering Algorithm guided by Neuroendoscopy in the treatment of Tumors in the Saddle Region. Pak J Med Sci. 2021;37(6):1600-1604. doi: https://doi.org/10.12669/pjms.37.6-WIT.4850 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Giant Chondroma of the Saddle Area: Case Report and Literature Review*

Cited by 5 publications

References 38 publications

Giant skull base periosteal chondroma treated with endonasal endoscopic surgery: illustrative case

Giant skull base periosteal chondroma treated with endonasal endoscopic surgery: illustrative case

Surgical Strategies and Outcomes for Intracranial Chondromas: A Retrospective Study of 17 Cases and Systematic Review

Application of MRI images based on Spatial Fuzzy Clustering Algorithm guided by Neuroendoscopy in the treatment of Tumors in the Saddle Region

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