Giant condyloma acuminata with syringocystadenoma papilliferum

Sardesai, Vidyadhar R; Agarwal, Vaishali M; Manwatkar, Pradnya; Gharpuray, Mohan B

doi:10.4103/0378-6323.51250

Cited by 8 publications

(5 citation statements)

References 3 publications

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“…Among 18 cases of SCAP with such a morphology described in the literature, the most common location was the cheek (16.7%), scalp (16.7%), and lower extremity (16.7%) followed by the buttock (11.1%), neck (11.1%), vulva (5.5%), sacral area (5.5%), back (5.5%), аreola (5.5%), and eyelid (5.5%). 2,[19][20][21][22][23][24][25] The cause of such contiguous verrucous proliferations in SCAP is unclear. Some authors have suggested a possible role of HPV infection.…”

Section: Discussionmentioning

confidence: 99%

Syringocystadenoma Papilliferum of the Anogenital Area and Buttocks: A Report of 16 Cases, Including Human Papillomavirus Analysis and HRAS and BRAF V600 Mutation Studies

Konstantinova

Kyrpychova

Němcová

et al. 2019

The American Journal of Dermatopathology

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Syringocystadenoma papilliferum (SCAP) is a benign tumor most commonly located on the head and neck area often associated with nevus sebaceus. In its usual location, the human papillomavirus (HPV) DNA and mutations in the RAS/mitogen-activated protein kinase signaling pathway have been detected in SCAP. We studied 16 cases of SCAP in the anogenital areas and buttock where this neoplasm is rare and attempted to find out whether SCAP in these sites have different histopathological and molecular biological features. It seems that there is no significant difference between the morphology of anogenital SCAP and SCAP in other locations. Several tumors in our cohort demonstrated features resembling those seen in warts, but HPV DNA was not found in these lesions. On the contrary, we identified DNA of HPV high-risk types in some tumors without HPV-related morphology. Our study confirms the role of HRAS and BRAF V600 mutations in the pathogenesis of SCAP, including SCAP in the anogenital areas and buttock.

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Section: Discussionmentioning

confidence: 99%

Syringocystadenoma Papilliferum of the Anogenital Area and Buttocks: A Report of 16 Cases, Including Human Papillomavirus Analysis and HRAS and BRAF V600 Mutation Studies

Konstantinova

Kyrpychova

Němcová

et al. 2019

The American Journal of Dermatopathology

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“…Recently, we encountered a peculiar case of a sporadic SCAP occurring on the right areola of a male patient, which on histology appeared to arise in association with an endophytic wart. On review of the literature, there have been only a handful of isolated cases with explicit descriptions of SCAP arising in contiguity with verruca . However, after more careful review, we were able to identify multiple other published cases of SCAP which lacked explicit mention of this association, but nevertheless showed these changes in the published images .…”

Section: Introductionmentioning

confidence: 87%

Contiguous verrucous proliferations in syringocystadenoma papilliferum: A retrospective analysis with additional evaluation via mutation‐specific BRAFV600E immunohistochemistry

et al. 2018

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“…[17][18][19] However, some consider that these cases actually represent pseudocarcinomatous hyperplasia in conjunction with syringocystadenoma. 20 Coyne and Fitzgibbon 21 described a case of a mixed syringocystadenoma papilliferum and papillary eccrine adenoma that co-existed with a scrotal condyloma.…”

Section: Discussionmentioning

confidence: 96%

Pseudocarcinomatous Hyperplasia Associated With Hidradenoma Papilliferum

Fernández-Flores

Valerdiz

2012

The American Journal of Dermatopathology

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Cutaneous pseudocarcinomatous hyperplasia is a benign proliferation that can be associated with many nontumoral and tumoral conditions. In the literature, squamous proliferations of different types have been associated with several types of adnexal adenomas. However, we found no reported case of association of hidradenoma papilliferum with pseudocarcinomatous hyperplasia. We had the opportunity of studying this type of an association in a 38-year-old man. The hidradenoma was located deep in the corion of the biopsy and the uppermost squamous epithelium showed a pseudocarcinomatous hyperplasia that focally contacted with the hidradenoma. No atypia was noted in the squamous proliferation. E-cadherin was diffusely expressed by the squamous nests, whereas p53 and Ki-67 were restricted to the basal layer. Cyclin D-1 was expressed in the parabasal layer. Immunohistochemistry of the squamous proliferation was negative for human papillomavirus.

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Giant condyloma acuminata with syringocystadenoma papilliferum

Cited by 8 publications

References 3 publications

Syringocystadenoma Papilliferum of the Anogenital Area and Buttocks: A Report of 16 Cases, Including Human Papillomavirus Analysis and HRAS and BRAF V600 Mutation Studies

Syringocystadenoma Papilliferum of the Anogenital Area and Buttocks: A Report of 16 Cases, Including Human Papillomavirus Analysis and HRAS and BRAF V600 Mutation Studies

Contiguous verrucous proliferations in syringocystadenoma papilliferum: A retrospective analysis with additional evaluation via mutation‐specific BRAFV600E immunohistochemistry

Pseudocarcinomatous Hyperplasia Associated With Hidradenoma Papilliferum

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