Giant congenital juvenile xanthogranuloma presenting as a yellowish atrophic plaque

Pinto, Cristian; Lechuga, Mauricio; Bellolio, Enrique; González, Sergio; Schafer, Fabiola

doi:10.1111/1346-8138.12453

Cited by 8 publications

(14 citation statements)

References 5 publications

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“…To our knowledge, 51 cases of giant JXG have been reported in the English literature. 8,10-50 We analyzed all cases of giant JXG for various characteristics. In our analysis, we also compared giant JXG and classic JXG (Table 1).…”

Section: Discussionmentioning

confidence: 99%

Giant Juvenile Xanthogranuloma: Case Report, Literature Review, and Algorithm for Classification

Ladha

Haber

2018

J Cutan Med Surg

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Juvenile xanthogranuloma (JXG) is a member of the non-Langerhans cell group of proliferative disorders of mononuclear phagocytes. JXG is a benign tumour of histiocytic cells. Classic JXG is divided into 2 main clinical subtypes: dome-shaped papules (<0.5 cm) and single/multiple nodules (<2.0 cm). A rare variant is referred to as giant; this term encompasses JXG lesions larger than 2.0 cm. In this article, we report a case of a congenital cutaneous giant JXG. In addition, we reviewed and analyzed all cases (n = 51) of giant JXG reported in the English literature. We propose an algorithm for classifying giant JXG based on the following factors: onset of lesions (congenital and acquired), number of lesions (solitary ± satellites and multiple), morphology of cutaneous/mucosal lesions (plaque, nodular, ulcerated-nodular, macular, and other), and extracutaneous manifestations.

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Section: Discussionmentioning

confidence: 99%

Giant Juvenile Xanthogranuloma: Case Report, Literature Review, and Algorithm for Classification

Ladha

Haber

2018

J Cutan Med Surg

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“…The most common clinical morphology was a firm, well-circumscribed tumor that increased in size over the first few months of life and had a yellow to erythematous color. Less common morphologies included exophytic tumors (6 cases), 3,6,10,15,25 agminated juvenile xanthogranulomas occurring on an erythematous patch or plaque (4 cases) 8,18,21,22 (Figure 4), large infiltrative plaques (5 cases) 11,17,19,24,28 (Figure 5), and subcutaneous masses without significant overlying skin change (4 cases). 2,9,13,26 Nine percent of the patients catalogued (3/33) had multiple cutaneous congenital lesions.…”

Section: Resultsmentioning

confidence: 99%

“…We excluded non‐English journal articles, cases without congenital onset, cases without histopathologic confirmation, and cases of systemic JXG without cutaneous congenital JXGs. In total, we identified 31 cases of congenital JXG involving the skin only and 16 cases of congenital JXG with systemic involvement …”

Section: Methodsmentioning

confidence: 99%

Congenital‐type juvenile xanthogranuloma: A case series and literature review

Oza

Stringer

Campbell³

et al. 2018

Pediatric Dermatology

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The medical literature supports that congenital juvenile xanthogranulomas behave in a fashion similar to that of juvenile xanthogranulomas of infancy or childhood. Congenital cutaneous juvenile xanthogranulomas with or without systemic involvement spontaneously regress. The varied clinical presentations in the skin may lead to misdiagnosis, inappropriate examination, and unnecessary treatments. Infants with multiple congenital cutaneous juvenile xanthogranulomas should be evaluated for systemic involvement, with a particular focus on the liver, because 72.2% of these children were found to have hepatic juvenile xanthogranulomas.

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“…7 Some rare variants exist, such as giant JXG. Other different presentations have been reported in the literature, including atrophic plaque, 10 cutaneous horn, 11 and subcutaneous mass. 3,4,12…”

Section: Discussionmentioning

confidence: 98%

A Rare Case of Solitary Giant Congenital Juvenile Xanthogranuloma: A Case Report

et al. 2017

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Juvenile xanthogranuloma (JXG) is the most frequent form of non-Langerhans cell histiocytosis. We present a case of giant congenital JXG in a 7-week-old boy, who had a firm and incompressible lesion, measuring 3 × 4 cm in diameter, on his right flank. The clinical appearance of the lesion and the ultrasound results suggested a vascular tumor, such as a hemangioma. Histology confirmed a JXG, although there was an absence of Touton cells, which are usually pathognomonic of JXG. In light of these findings, it would be important to include JXG in the differential diagnosis of congenital tumours, particularly vascular lesions.

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Giant congenital juvenile xanthogranuloma presenting as a yellowish atrophic plaque

Cited by 8 publications

References 5 publications

Giant Juvenile Xanthogranuloma: Case Report, Literature Review, and Algorithm for Classification

Giant Juvenile Xanthogranuloma: Case Report, Literature Review, and Algorithm for Classification

Congenital‐type juvenile xanthogranuloma: A case series and literature review

A Rare Case of Solitary Giant Congenital Juvenile Xanthogranuloma: A Case Report

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