Giant congenital melanocytic nevus in a Cameroonian child: a case report

Abstract

BackgroundGiant congenital melanocytic nevus is a very rare condition characterized by a large skin lesion and an increased risk of complications like neurocutaneous melanosis and malignant transformation. Reports of giant congenital melanocytic nevus are scarce in the sub-Saharan African literature and here we present a case of this disease in a Cameroonian adolescent.Case presentationA 12-year-old Cameroonian girl from the "Baka" ethnic group, with no relevant family and medical histories presented with a progressively extensive brownish-black nodular hypertrophic skin lesion of approximately 45 cm, which she had had since she was 2-days old. The lesion covered her entire back giving an appearance of “turtle child”, which was highly suggestive of a giant congenital melanocytic nevus. She was booked in for a surgical intervention organized by a health campaign within her community. Meanwhile she was provided with psychological support and her family was counseled on warning signs of complications which would warrant an urgent consultation.ConclusionsHere we presented a case of giant congenital melanocytic nevus, apparently the first in the Cameroonian literature. In view of the potential severe complications as well as psychological trauma of this pathology, we draw clinicians’ attention to this extremely rare but real pathology in our country, for a timely diagnosis and management.

Melanocortin-1 receptor (MC1R) genotypes do not correlate with size in two cohorts of medium-to-giant congenital melanocytic nevi

“…Children from dark-skinned populations of sub-Saharan Africa, in whom non-synonymous MC1R variants are rare (reviewed in Herraiz et al, 2017), also develop the largest, G2-type CMN (Katibi, Ogunbiyi, Brown & Adeyemi, 2014;Endomba, Mbega, Tochie & Petnga, 2018). Altogether, these data indicate that MC1R…”

“…Thus, the significant association of the p.V92M variant with a lower PAS of the CMN in Spanish patients might be a spurious result caused by both the low frequency of the variant and the limited size of the giant CMN patient subset. Children from dark-skinned populations of sub-Saharan Africa, in whom non-synonymous MC1R variants are rare (reviewed in Herraiz et al, 2017), also develop the largest, G2-type CMN (Katibi, Ogunbiyi, Brown & Adeyemi, 2014; Endomba, Mbega, Tochie & Petnga, 2018). Altogether, these data indicate that MC1R genotype is not likely to contribute to a larger CMN sizeCMN.…”

Melanocortin‐1 receptor (MC1R) genotypes do not correlate with size in two cohorts of medium‐to‐giant congenital melanocytic nevi

“…Children from dark-skinned populations of sub-Saharan Africa, in whom non-synonymous MC1R variants are rare (reviewed in Herraiz et al, 2017), also develop the largest, G2-type CMN (Katibi, Ogunbiyi, Brown & Adeyemi, 2014;Endomba, Mbega, Tochie & Petnga, 2018). Altogether, these data indicate that MC1R genotype is not likely to contribute to a larger CMN sizeCMN.…”

Giant Congenital Melanocytic Nevi (GCMN): Sebuah Laporan Kasus Langka

“…Lesi paling banyak ditemukan di badan, terutama di bagian atas atau bawah punggung. Gambaran khasnya dapat berupa "cape", "bathing trunk", "tippet", atau "garment", sesuai dengan distribusinya (Balomenou et al, 2019;Endomba et al, 2018;James et al, 2016;Sakhiya et al, 2020;Viana et al, 2013;Wolff et al, 2013). Sebanyak 75% kasus CMN didapatkan lesi kecil dan multipel yang disebut lesi satelit.…”

“…Jika lesi tersebut lebih dari 20, biasanya berhubungan dengan kelainan neurologik (Abubakar et al, 2018;Balomenou et al, 2019;Endomba et al, 2018;Griffiths et al, 2016;Habif, 2004). (Balomenou et al, 2019;Habif, 2004;Meshram et al, 2018).…”