Giant extragastrointestinal stromal tumor in the transverse mesocolon concomitant with gastric cancer in an elderly patient: Case report

Xue, Dong; Chen, Hongqiang; Chen, Yuxin

doi:10.3892/ol.2012.1030

Cited by 4 publications

(2 citation statements)

References 15 publications

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“…EGISTs of the transverse mesocolon are exceptionally rare, with only case report data available. Six cases of transverse mesocolon EGIST were identified on review of the literature,8–13 with this being the first published in Australasia. The symptoms of EGIST are non-specific and generally are caused by their mass effect alone.…”

Section: Discussionmentioning

confidence: 99%

Extragastrointestinal stromal tumour of the transverse mesocolon mimicking giant ovarian cystic neoplasm

Wood

Janssen²,

Aljanabi³

2023

BMJ Case Rep

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Gastrointestinal stromal tumours (GISTs) are mesenchymal tumours which are most commonly found along the gastrointestinal tract. They are more rarely found in an extragastrointestinal location and typically present late due to only vague symptoms from mass effect. There are very few case reports of GIST arising within the transverse mesocolon. We report a case of a large cystic transverse mesocolic GIST which preoperative imaging concluded was likely of ovarian origin. This resulted in an abrupt change in the surgical management intraoperatively, but fortunately, an R0 resection was still achieved. This serves as an important lesson to keep the differential diagnosis broad when dealing with large cystic abdominal masses. The tumour was found to be KIT wild type, with a platelet-derived growth factor receptor alpha D842V mutation identified, conferring intrinsic resistance to imatinib.

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Section: Discussionmentioning

confidence: 99%

Extragastrointestinal stromal tumour of the transverse mesocolon mimicking giant ovarian cystic neoplasm

Wood

Janssen²,

Aljanabi³

2023

BMJ Case Rep

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“…Surgical resection is currently the primary treatment option for non-metastatic EGISTs (6). For prostatic masses, transrectal ultrasound-guided prostate biopsies may assist in the determination of a treatment strategy.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis and multimodal therapy for extragastrointestinal stromal tumor of the prostate: A case report

Ou¹,

Cao²,

He³

et al. 2013

Experimental and Therapeutic Medicine

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Extragastrointestinal stromal tumors (EGISTs), which are neoplasms outside the digestive tract, are predominantly observed in the greater omentum and retroperitoneum. The clinicopathological and molecular characteristics of EGISTs are similar to those of gastrointestinal stromal tumors (GISTs). EGISTs originating from the prostate are extremely rare. In this study, we report a case of a prostatic EGIST in a 39-year-old male, who presented with frequency, urgency, dysuria and a prostatic mass. A 10-core transrectal ultrasound-guided prostate biopsy was performed, and the histological and immunohistochemical results confirmed the diagnosis of EGIST. The patient received a radical prostatectomy, followed by targeted therapy with imatinib (400 mg, daily) for 1 year. Neither recurrence nor metastasis was detected at a 24-month follow-up.

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Clinicopathological features and prognosis of mesenteric gastrointestinal stromal tumor: evaluation of a pooled case series

Feng

Liu

et al. 2017

Oncotarget

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BackgroundDue to the extremely rare incidence, data of clinicopathological features and prognosis of mesenteric gastrointestinal stromal tumors (GISTs) are limited. Therefore, the aim of the present study was to investigate the clinicopathological features and prognosis of mesenteric GISTs.Patients and MethodsMesenteric GISTs cases were obtained from our center and from case reports and clinical series extracted from MEDLINE. Clinicopathological features and survivals were analyzed.ResultsA total of 114 mesenteric GISTs were enrolled in present study. The most common symptom was abdominal pain (20/72, 27.8%), followed by abdominal mass (13/72, 18.1%) and distention (9/72, 12.5%). Most tumors exceeded 10 cm in diameter (71/112, 63.4%), exceeded 5/50HPF in mitotic index (50/85, 58.8%), and were high risk (82/90, 91.1%). The five-year disease free survival (DFS) and disease specific survival (DSS) was 57.7% and 60.1%, respectively. Tumor size and mitotic index were associated with DFS and DSS. The distribution of tumor size, histological type, mitotic index and NIH risk category were significantly different between mesenteric and gastric GISTs. Prognosis of mesenteric GISTs was worse than that of gastric GISTs. However, multivariate analysis showed that location was not an independent prognostic factor for mesenteric and gastric GISTs.ConclusionsMost mesenteric GISTs exceeded 10 cm in diameter, exceeded 5/50HPF in mitotic index and were high risk. Mesenteric GISTs differed significantly from gastric GISTs in respect to clinicopathologic features. Mitotic index and tumor size were prognostic factors for mesenteric GISTs. The prognosis were comparable between mesenteric and gastric GISTs.

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Giant extragastrointestinal stromal tumor in the transverse mesocolon concomitant with gastric cancer in an elderly patient: Case report

Cited by 4 publications

References 15 publications

Extragastrointestinal stromal tumour of the transverse mesocolon mimicking giant ovarian cystic neoplasm

Extragastrointestinal stromal tumour of the transverse mesocolon mimicking giant ovarian cystic neoplasm

Diagnosis and multimodal therapy for extragastrointestinal stromal tumor of the prostate: A case report

Clinicopathological features and prognosis of mesenteric gastrointestinal stromal tumor: evaluation of a pooled case series

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