Giant fibrous hamartoma of infancy: A report of two cases and review of the literature

Fibrous Hamartoma of Infancy: A Firm Plaque Presenting with Hypertrichosis and Hyperhidrosis

“…FHIs are typically small, with the largest previously reported lesion measuring 11 cm in diameter (8). Two lesions measuring 15 cm (9) and 20 cm (10) in diameter have been described, although the diagnosis of FHI was questioned (8,9). To our knowledge, our patient's 12-cm 9 3-cm lesion represents one of the largest reported FHIs (8).…”

“…These growths are characteristically painless and freely mobile, although they may adhere to the underlying subcutaneous tissue . FHIs are typically small, with the largest previously reported lesion measuring 11 cm in diameter . Two lesions measuring 15 cm and 20 cm in diameter have been described, although the diagnosis of FHI was questioned .…”

“…Two lesions measuring 15 cm (9) and 20 cm (10) in diameter have been described, although the diagnosis of FHI was questioned (8,9). To our knowledge, our patient's 12-cm 9 3-cm lesion represents one of the largest reported FHIs (8). Furthermore, although FHIs may have overlying skin changes, such as alterations in pigment (7) and hypertrichosis (11), review of the literature describes only one previous case of an FHI presenting with sweat production secondary to eccrine hyperplasia (12).…”

Giant fibrous hamartoma of infancy

“…[ 4 , 5 ] Majority of the studies indicated that aggressive, mutilating resections should be avoided due to the excellent overall prognosis and low recurrence rate, although some studies recommended local radical excision in order to prevent accelerated spread of the tumor. [ 15 ] In the present report, a treatment strategy of destructive amputation of the left hip and the left lower extremity was forced to be selected because of the giant size, infiltration, rapid growth of the tumor, and the immobility of the left leg. Now, the patient can walk and play like a normal child with the help of artificial extremity.…”

Beyond infections: tumors and malformations of the diaper area

“…When the tumor is removed via excision, it is considered cured and local recurrence is rare. 15 Another recently described condition is the plaque-like myofibroblastic tumor of infancy (PMTI), which, although rare, seems to arise peculiarly on the lower back and hip in the first 2 years of life. Growth may be slow or rapid, and lesions may be asymptomatic or painful.…”