Giant Functioning Parathyroid Cyst Presenting as a Retrosternal Goitre

McKay, Gary D; Ng, Tsz Wai; Morgan, Gary J.; Chen, Roger C

doi:10.1111/j.1445-2197.2007.04037.x

Cited by 38 publications

(59 citation statements)

References 20 publications

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“…Parathyroid cysts are an uncommon entity in the usual clinical setting (1,14,15). The first description of a parathyroid cyst and parathyroid gland in humans was done in 1880 by the Swedish anatomist Ivar Sandström (16)(17)(18), but only in 1905 the first surgical resection was performed by Goris (19) and several years later, Crile in 1953 become the first to diagnose a parathyroid cyst by fine needle aspiration (20).…”

Section: Discussionmentioning

confidence: 99%

Parathyroid cysts: the Latin-American experience

et al. 2016

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Background: Parathyroid cyst is an infrequent and unsuspected disease. There are more than 300 hundred cases reported in the world literature, a few of them are from Latin America. The experience of our centers and a review of the cases are presented.Methods: Case report of a series of patients with parathyroid cyst from our institutions according to the CARE guidelines (Case Reports). A search of Medline, Embase, BIREME (Biblioteca Regional de Medicina) LILACS (Literatura Latinoamericana y del Caribe en Ciencias de la Salud), Google Scholar and Scielo (ScientificElectronic Library on Line) databases and telephonic or email communications with other experts from LatinAmerica was performed .Results: Six patients with parathyroid cyst were found in our centers in Colombia. Most of them were managed with aspiration of the cyst. Two of them required surgery. Only one case was functional. Twelve reports from Latin America were found for a total of 18 cases in our region adding ours.

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Section: Discussionmentioning

confidence: 99%

Parathyroid cysts: the Latin-American experience

et al. 2016

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“…Giant PCs that extend between the lower neck and superior mediastinum are even rarer. McKay et al (11) reported that in all of the PubMed studies that were published since 1925, only 107 giant non-functioning PCs had been reported. The study regarding large parathyroid cystic lesions that was conducted by Rossi et al (12) reported a 0.09% incidence over the last 15 years.…”

Section: Case Reportmentioning

confidence: 99%

Giant non-functional parathyroid cyst: A case report

Zhang

Yuan

et al. 2016

Oncology Letters

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Abstract. Giant parathyroid cysts (PCs) are a rare entity and possess a benign clinical course. PCs may be functional or non-functional, depending on the ability of the cyst to secrete parathyroid hormone (PTH). The present study reports a rare case of a giant PC in a 56-year-old male who presented to the Affiliated Tumor Hospital, Zhengzhou University (Zhengzhou, Henan, China) with a 10-month history of exertional dyspnea, associated with mild dysphagia that had persisted for 3 months. The present study reviews the clinical situation, laboratory examination, radiographic findings, treatment and prognosis of the patient, and provides a brief discussion regarding the associated literature. Giant PCs may manifest with compressive symptoms of the surrounding tissues. The diagnosis of a giant PC is based on increased levels of PTH in the fluid collected during the aspiration of the cyst. Management by surgical excision is recommended for giant PCs that cause local cervical symptoms.

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“…PCs may be functioning or non-functioning. Nonfunctioning cysts encompass 90 % of cases and occur more commonly in females [13,14]. Functioning cysts usually affect males and are associated with primary HPT [13].…”

Section: Introductionmentioning

confidence: 99%

“…Although most PCs are orthotopic, ectopic localization is possible in the cervical region, including both the thyroid and thymus [15][16][17][18]. Mediastinal PCs are usually large (C4 cm), causing compressive symptoms such as dysphagia and dyspnea [13,19,20], at times mimicking retrosternal goitre [14]. Vocal cord paralysis due to compression on the recurrent laryngeal nerve [21][22][23], respiratory failure and jugular or innominate vein thrombosis have also been reported as complications [24].…”

Section: Introductionmentioning

confidence: 99%

Cystic parathyroid glands in MEN1: A rare entity?

et al. 2016

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Approximately 300 cases of sporadic parathyroid cyst (PCs) have been reported to date. Only two cases have been described in MEN1 so far. Detection by imaging could be challenging, especially in multiglandular primary hyperparathyroidism (HPT) and clinical outcome could be different. During the period 1990-2014, 71 MEN1 patients were operated for primary hyperparathyroidism in our centre. We report three cases of PCs in MEN1 patients affected by HPT, who underwent a total or subtotal parathyroidectomy with transcervical thymectomy. In our series, all three patients had an unsatisfactory postoperative course, at variance with the high percentage (over 90 %) of long-term success in MEN1 patients operated at our centre. One patient affected by cystic degeneration of all the four parathyroid glands reported persistent hypoparathyroidism, despite autografts of parathyroid tissue. For the other two cases, surgery failed to cure hyperparathyroidism, perhaps because of the presence of undetected ectopic parathyroid tissue. In the context of a multiglandular disease such as MEN1 syndrome, PCs seem rare but our experience shows about a 4 % incidence. Furthermore their presence, even in expert hands, could affect the preoperative identification of the parathyroid glands due to the difficult differential diagnosis between PC and other cystic lesions of the neck, and intraoperative detection of the glands as well as the postoperative outcome.

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Giant Functioning Parathyroid Cyst Presenting as a Retrosternal Goitre

Cited by 38 publications

References 20 publications

Parathyroid cysts: the Latin-American experience

Parathyroid cysts: the Latin-American experience

Giant non-functional parathyroid cyst: A case report

Cystic parathyroid glands in MEN1: A rare entity?

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