Giant Fungating Basal Cell Carcinoma of the Scrotum

Delto, Joan C.; Garcés, Sofía; Sidhu, Ajaydeep S.; Ghaffaripour, Taban; Omarzai, Yumna; Nieder, Alan M.

doi:10.1016/j.urology.2016.01.030

Cited by 6 publications

(6 citation statements)

References 4 publications

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“…Most authors agree that surgery is the mainstay of treatment for localized scrotal BCC (Delto et al 2016;Jeon et al 2006;Ribuffo et al 2002;Wang et al 2010). A clear surgical margin of > 6 mm reduces the risk of disease relapse (Delto et al 2016).…”

Section: Discussionmentioning

confidence: 99%

“…A clear surgical margin of > 6 mm reduces the risk of disease relapse (Delto et al 2016). Other authors advocate greater clear surgical margin of 2-3cm for complete resection of the local disease (Hernández-Aragüés & Baniandrés-Rodríguez 2016).…”

Section: Discussionmentioning

confidence: 99%

“…It is thought to be more aggressive and metastasizes earlier than BCC of other parts of the body (Kinoshita et al 2005). Localized scrotal BCC is usually treated with wide local excision (Delto et al 2016;Jeon et al 2006;Ribuffo et al 2002;Wang et al 2010) but metastatic disease may require systemic chemotherapy for disease control yrs. The job involved exposure and close contact with various chemicals including magnesium sulphate, nitric oxide, ammonia, paraquat, liquid hydrogen, chlorine gas and sulphur compounds.…”

Section: Introductionmentioning

confidence: 99%

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A Rare Case of Scrotal Basal Cell Carcinoma in the Presence of Metastatic Squamous Cell Carcinoma of the External Auditory Meatus and its Management Strategy

Tan¹,

Elsa²,

Fam³

et al. 2017

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ABSTRAK Penyakit kanser sel basal (KSB) di bahagian skrotum jarang ditemui dan punca ia berlaku tidak difahami dengan baik. KSB yang tumbuh di skrotum ini dikatakan lebih agresif dan mempunyai kebolehan merebak yang lebih tinggi daripada ABSTRACTBasal cell carcinoma (BCC) of the scrotum is uncommon and its pathogenesis is not well understood. The clinical behaviour of scrotal BCC is thought to be more aggressive and has a higher metastatic potential than BCC of other regions. The mainstay of treatment for localized scrotal BCC is wide local excision, while metastatic disease may need systemic chemotherapy for palliative control. A rare clinical scenario of scrotal BCC presenting concurrently with another metastatic cancer has never been reported. The present case illustrates the diagnostic challenge and management dilemma due to simultaneous presentation of scrotal BCC and metastatic squamous cell carcinoma (SCC). A 70-year-old man complained of a non-healing scrotal ulcer while he was being investigated for metastatic squamous cell carcinoma (SCC) of the external auditory meatus. The scrotal lesion was initially thought to be metastatic SCC. It was later confirmed to be BCC with biopsy and histopathological examination. He underwent surgical resection of the scrotal BCC for local control followed by palliative chemotherapy with cisplatin and radiotherapy for lymph node metastases. He remained well and did not have any local recurrence following 6 months after palliative treatment. Surgery coupled with palliative chemoradiation can offer good quality of life for patients with scrotal BCC and concurrent metastatic SCC.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Rare Case of Scrotal Basal Cell Carcinoma in the Presence of Metastatic Squamous Cell Carcinoma of the External Auditory Meatus and its Management Strategy

Tan¹,

Elsa²,

Fam³

et al. 2017

View full text Add to dashboard Cite

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“…Partial bladder outlet obstruction (pBOO) caused by many etiologies, including benign prostatic hyperplasia, cystocele, posterior urethral valves, bladder stones, and urethral stricture, is a common disease of the urinary tract. After the female Sprague-Dawley rats received EGCG treatment, bladder injury and dysfunction was significantly promoted by inhibiting inflammation and ERS-related apoptosis with increased the expression of caspase-12, CHOP, and cyclooxygenase-2 at 48 hours and 30 days [ 117 , 118 ]. ERS-induced apoptosis closely correlated with the progression of age-related macular degeneration.…”

Section: The Role Of Egcg In Ers-induced Apoptosis and Human Diseasesmentioning

confidence: 99%

The Role of Epigallocatechin-3-Gallate in Autophagy and Endoplasmic Reticulum Stress (ERS)-Induced Apoptosis of Human Diseases

2020

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“…Silencing target genes using siRNA is another way to inhibit tumor growth. As overexpression of polo-like kinase (PLK)-1 is associated with the development of bladder cancer, one study showed that treatment with PLK-1 siRNA containing exosomes inhibited bladder cancer growth [ 138 ]. Similarly, as GRP78 overexpression is implicated in the growth and metastasis of hepatocellular carcinoma, treatment with GRP78 siRNA expressing exosomes resulted in an efficacious antitumor response in a sorafenib-resistant hepatocellular carcinoma model [ 139 ].…”

Section: Potential Therapeutic Applications Of Exosomes In Cancermentioning

confidence: 99%

The Biological Function and Therapeutic Potential of Exosomes in Cancer: Exosomes as Efficient Nanocommunicators for Cancer Therapy

Choi

Park

Lee

et al. 2020

IJMS

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Cancer therapeutics must be delivered to their targets for improving efficacy and reducing toxicity, though they encounter physiological barriers in the tumor microenvironment. They also face limitations associated with genetic instability and dynamic changes of surface proteins in cancer cells. Nanosized exosomes generated from the endosomal compartment, however, transfer their cargo to the recipient cells and mediate the intercellular communication, which affects malignancy progression, tumor immunity, and chemoresistance. In this review, we give an overview of exosomes’ biological aspects and therapeutic potential as diagnostic biomarkers and drug delivery vehicles for oncotherapy. Furthermore, we discuss whether exosomes could contribute to personalized cancer immunotherapy drug design as efficient nanocommunicators.

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Giant Fungating Basal Cell Carcinoma of the Scrotum

Cited by 6 publications

References 4 publications

A Rare Case of Scrotal Basal Cell Carcinoma in the Presence of Metastatic Squamous Cell Carcinoma of the External Auditory Meatus and its Management Strategy

A Rare Case of Scrotal Basal Cell Carcinoma in the Presence of Metastatic Squamous Cell Carcinoma of the External Auditory Meatus and its Management Strategy

The Role of Epigallocatechin-3-Gallate in Autophagy and Endoplasmic Reticulum Stress (ERS)-Induced Apoptosis of Human Diseases

The Biological Function and Therapeutic Potential of Exosomes in Cancer: Exosomes as Efficient Nanocommunicators for Cancer Therapy

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