Giant glioependymal cyst in an infant

Morigaki, Ryoma; Shinno, Kiyohito; Pooh, Kyong Hon; Nakagawa, Yoshinobu

doi:10.3171/2010.11.peds10270

Cited by 13 publications

(9 citation statements)

References 10 publications

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“…Due to the limited case reports of symptomatic or asymptomatic autopsy ones, the natural history of asymptomatic NEC remains unknown. Previous reports suggest that NECs grow due to increased secretion from epithelial cells rather than from a neoplastic growth [ 2 ]; however, our patient had no apparent history of trauma or intracranial inflammatory disease that could have accelerated cyst secretion. Moreover, the evidence of secretion like the presence of cilia was not confirmed pathologically, although this might be because of artifacts in the preparation of the slides.…”

Section: Discussionmentioning

confidence: 76%

“…NEC is the collective name for ependymal and glioependymal cysts [ 2 ]. To differentiate these, pathological examinations are essential: ependymal cysts have connective tissue and an epithelial lining which is a single layer of cuboidal epithelial cells, while glioependymal cysts have a glial layer between the connective tissue and epithelial lining [ 1 2 ]. Given that the specimen of the present case did not show a glial layer, we considered that the proper diagnosis was ependymal cyst.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Symptomatic Change of an Intracranial Neuroepithelial Cyst 7 Years After Its Incidental Finding

Niwa

Isoo

Komori

et al. 2022

Brain Tumor Res Treat

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A natural course of asymptomatic neuroepithelial cysts (NECs) is poorly understood due to its rarity. Herein we report a 23-year-old female patient of an asymptomatic NEC which grew in size from 1 cm to 5 cm and caused progressive symptoms seven years after its incidental finding. Partial resection of the cyst was performed for decompression and pathological examination and effectively achieved symptoms alleviation and regression of the cyst. Our case showed the importance of regular follow-up because NECs may show symptomatic change even in the late phase.

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Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Symptomatic Change of an Intracranial Neuroepithelial Cyst 7 Years After Its Incidental Finding

Niwa

Isoo

Komori

et al. 2022

Brain Tumor Res Treat

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“…GECs are benign intracranial cysts that have rarely been reported in the literature, 21,22,[24][25][26][27][28][29][30] especially concerning cysts located in the interhemispheric space, which only account for 11.1% of all GEC cases. 8 We are convinced that this report would provide valuable information regarding intracranial cysts.…”

Section: Discussionmentioning

confidence: 99%

A large interhemispheric glioependymal cyst associated with partial defect of the corpus callosum in an elderly man

et al. 2020

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Interhemispheric cysts are congenital, and usually present symptoms during childhood. However, they are occasionally detected in adults. These cystic lesions are sometimes associated with defects of the corpus callosum. Although defects of the corpus callosum by themselves do not present clinical symptoms, they are often accompanied by other brain malformations. A man in his late 60s was found dead at the scene of a fire. At autopsy, his brain weighed 1223 g and had a large interhemispheric cyst, measuring 5.5 × 4.5 × 4.0 cm in size. The cyst contained clear fluid but was not connected to the ventricular system. On slices of the cerebrum, the corpus callosum did not connect the right and left cerebral hemispheres, and the right lateral ventricle was dilated. By the existence of the cyst, compressed by the cyst, the hemispheres were displaced on either side. Histologically, the cerebral parenchyma around the cyst was slightly edematous but structurally normal. Immunohistochemically, both glial fibrillary acidic protein and podoplanin were expressed in the cystic components. Thus, the cystic lesion was diagnosed as a glioependymal cyst. In this case, because the cyst was located at the interhemispheric space between the right and left frontal lobes, the individual experienced no obvious symptoms, despite its large size. The individual's brain malformations included the partial defect of the corpus callosum and the cyst. The dilation of the right lateral ventricle was considered to result from the location of the cyst. Under the influence of the cyst, the third ventricle was displaced downward, and one or both of the interventricular foramen were obstructed. The decedent had burns over his whole body. Burns to the epiglottis and soot in the airway were also observed. Volatile hydrocarbons, such as benzene and styrene, were detected in the blood. The percentage of carboxyhemoglobin levels in a total of hemoglobin levels were 19-25%. Therefore, the individual's cause of death was established as death by fire.

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“…1 Maximum cases reported till now are found in neonates and children and the origin of these cysts is controversial. [3][4][5][6][7][8] They are usually congenital lesions that develop a sequestration of neural tube embryonic elements that develop into a glial cell lined fluid-filled cavity located within the white matter. In our case, the cyst maybe considered as a result of neuroglial heterotopia.…”

Section: Presentation Of Casementioning

confidence: 99%