Giant hemangioendothelioma with associated thrombocytopenia

Scherz, Robert G.; Louro, Jose M.; Geppert, Leo J.

doi:10.1016/s0022-3476(58)80095-5

Cited by 27 publications

(2 citation statements)

References 5 publications

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“…The use of corticosteroids has been a mainstay of therapy since their therapeutic benefits were first noted in 1958 during treatment of thrombocytopenia secondary to platelet sequestration (52). Corticosteroids have been shown to be antiangiogenic in a number of in vitro settings (53), however, the precise pathway of action by which corticosteroids catalyze the involution of hemangiomas is not known.…”

Section: Managementmentioning

confidence: 99%

Periocular Hemangiomas: What Every Physician Should Know

Ceisler¹,

Santos

Blei

2004

Pediatric Dermatology

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Hemangiomas are the most common benign tumor of infancy. Most hemangiomas remain asymptomatic and can be managed by close observation; however, immediate treatment is indicated for hemangiomas that may cause significant complications. Periocular hemangiomas warrant close evaluation and early, active treatment of those with the potential to threaten or permanently compromise vision. Herein we review the clinical features of periocular hemangiomas, differential diagnosis, possible ophthalmologic complications and sequelae, and therapeutic modalities.

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Section: Managementmentioning

confidence: 99%

Periocular Hemangiomas: What Every Physician Should Know

Ceisler¹,

Santos

Blei

2004

Pediatric Dermatology

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“…Surgical removal of the tumour, though effective, is hazardous. Corticosteroids have little effect on the course of this condition but may decrease capillary fragility and, occasionally, improve the platelet (Scherz et al 1958). Transfusion of fresh blood or platelet-rich plasma may be of temporary use during a crisis or surgery.…”

Section: Commentmentioning

confidence: 99%