Giant hepatocellular carcinoma with bone metastasis in a young adult, emerged from pigmented adenoma with beta-Catenin activation: A case report

Lünse, Sebastian; Döring, Paula; Heidecke, Claus–Dieter; Partecke, Lars Ivo

doi:10.1016/j.ijscr.2017.04.001

Cited by 5 publications

(5 citation statements)

References 16 publications

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“…Two of these patients had follow-up information (1 year and 9 years) with no evidence of recurrent disease. Twenty-six additional β-catenin mutated hepatocellular adenoma patients with malignant transformation previously reported in the literature were included in the analysis [12][13][14][15][16][17][18][19][20][21][22]. These patients were mostly male (65% male and 35% female) with an average age of 42 ± 14 years at the time of diagnosis (range: 20-66 years).…”

Section: Patients With Malignant Transformation Of β-Catenin Mutated ...mentioning

confidence: 99%

“…CharacteristicsLFABP-deficient hepatocellular adenomas β-catenin mutated hepatocellular adenomas a[12][13][14][15][16][17][18][19][20][21][22] P value HCC hepatocellular carcinoma, LFABP liver fatty acid binding protein, BCS Budd-Chiari syndrome, MODY maturity-onset diabetes of the young, DM diabetes mellitus, OCP oral contraceptive pills, GSD glycogen storage disease a β-catenin mutated hepatocellular adenoma cases included 4 cases from primary authors' institution and 26 cases from the literature[12][13][14][15][16][17][18][19][20][21][22] (see Supplementary Table1for details)…”

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confidence: 99%

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Malignant transformation of liver fatty acid binding protein-deficient hepatocellular adenomas: histopathologic spectrum of a rare phenomenon

et al. 2020

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Section: Patients With Malignant Transformation Of β-Catenin Mutated ...mentioning

confidence: 99%

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confidence: 99%

Malignant transformation of liver fatty acid binding protein-deficient hepatocellular adenomas: histopathologic spectrum of a rare phenomenon

et al. 2020

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“…The results from this study demonstrate that hepatic adenomas in older individuals have a high risk of malignancy (23% of cases) compared with adenomas in young to middle age patients (6%). These findings suggest that older age (age 60 years and older) could be added to other generally accepted risk factors for increased risk of malignant transformation in hepatic adenomas, including androgen and anabolic steroid use,2 male sex,27,28 heavy lipofuscin pigment deposition,12,29,30 myxoid morphology,15 and beta-catenin activation 4…”

Section: Discussionmentioning

confidence: 91%

Hepatic Adenomas in Patients 60 and Older Are Enriched forHNF1AInactivation and Malignant Transformation

Yasir

Chen

Jain

et al. 2022

American Journal of Surgical Pathology

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Hepatic adenomas occur most commonly in women between the ages of 20 and 40 years, but rarely they occur in older aged persons, including those 60 years of age or older. This group of adenomas, however, has not been systemically examined. Twenty-six hepatic adenomas in persons 60 years of age or older were studied, along with a control group of 50 hepatic adenomas in persons aged 30 to 39. Hepatic adenomas in persons 60 or more years of age were found in 21 women and 5 men, while the control group had 44 women and 6 men. Subtyping the adenomas in persons 60 years or older showed the following results: 18 HNF1A-inactivated adenomas (69%), 4 inflammatory adenomas (15%), and 4 unclassified adenomas (15%). In contrast, the control group showed a significantly different pattern (P=0.003), with a greater percentage of inflammatory adenomas (28, 56%), fewer HNF1A-inactivated adenomas (8, 16%), and more unclassified adenomas (14, 28%). Atypia and malignant transformation within the hepatic adenomas was studied next. Of the hepatic adenomas in persons age 60 or greater, 3 (12%) showed atypical histologic features, and 6 (23%) had a malignant transformation. In contrast, for hepatic adenomas in the control group, only 4 (8%) adenomas showed atypical histologic features, and 3 (6%) had undergone malignant transformation. In addition, the hepatic adenomas that were atypical or showed early malignant transformation were less likely to have beta-catenin activation in patients over 60 (2/9 cases) compared with those between 30 and 39 years (5/7 cases). Myxoid change and heavy lipofuscin deposition were also more common in adenomas in older aged persons. In conclusion, hepatic adenomas in persons 60 years of age or older are enriched for HNF1A-inactivated adenomas and have a higher frequency of malignant transformation. Malignant transformation, however, is less likely to develop through activation of the beta-catenin pathway.

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“…Extrahepatic metastasis of HCC was long thought to be a terminal event, so neither surgical resection nor ablation were considered [14,15]. The latest case report indicated that primary liver tumor surgery can improve the survival of HCC patients with BM [16]. Although some recent studies reported a series of molecular markers for predicting prognosis of HCC [24–26], few studies have reported on surgical treatment of the primary liver tumor among HCC patients with BM.…”

Section: Discussionmentioning

confidence: 99%

Advanced Hepatocellular Carcinoma with Bone Metastases: Prevalence, Associated Factors, and Survival Estimation

Guo

Wang

et al. 2019

Med Sci Monit

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Background The objective of the present research was to explore the prevalence, risk, and prognostic factors associated with bone metastases (BM) in newly diagnosed hepatocellular carcinoma (HCC) patients. Material/Methods From 36 507 HCC patients who were registered in Surveillance, Epidemiology, and End Results (SEER) database, we enrolled 1263 with BM at the initial diagnosis of HCC from 2010 to 2014. Kaplan-Meier curves and log-rank tests were used to estimate overall survival for different subgroups. Univariate and multivariate logistic and Cox regression analyses were performed to identify risk factors and independent prognostic factors for BM. Results A total of 1567 (4.29%) HCC patients were detected with BM at initial diagnosis. Male sex, unmarried status, higher T stage, lymph node involvement, intrahepatic metastases, and extrahepatic metastases (lung or brain) were positively associated with BM. The median survival of the patients was 3.00 months (95% CI: 2.77–3.24 months). Marital status and primary tumor surgery were independently associated with the better survival. Conclusions A list of factors associated with BM occurrence and the prognosis of the advanced HCC patients with BM were found. These associated factors may provide a reference for BM screening in HCC and guide prophylactic treatment in clinical settings.

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Giant hepatocellular carcinoma with bone metastasis in a young adult, emerged from pigmented adenoma with beta-Catenin activation: A case report

Cited by 5 publications

References 16 publications

Malignant transformation of liver fatty acid binding protein-deficient hepatocellular adenomas: histopathologic spectrum of a rare phenomenon

Malignant transformation of liver fatty acid binding protein-deficient hepatocellular adenomas: histopathologic spectrum of a rare phenomenon

Hepatic Adenomas in Patients 60 and Older Are Enriched forHNF1AInactivation and Malignant Transformation

Advanced Hepatocellular Carcinoma with Bone Metastases: Prevalence, Associated Factors, and Survival Estimation

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