Giant left atrium associated with massive thrombus formation

Darwazah, Ahmad K.; Sayed, Hamdy El

doi:10.1186/1477-9560-11-5

Cited by 13 publications

(10 citation statements)

References 16 publications

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“…We herein report a case of a giant RA seen in an adult patient with chronic rheumatic valve disease. The pathophysiology of a giant RA is not fully understood, as it is not seen in all patients with chronic valvular dysfunction who develop pressure and volume overload [ 2 ]. Interestingly, almost all previously reported cases of giant atrial enlargement in adults were in patients with a prior history of rheumatic heart disease ( Table 2 ).…”

Section: Discussionmentioning

confidence: 99%

Giant right atrium: a long-term complication of rheumatic heart disease

Abugroun

Taha

Daoud

et al. 2020

Oxford Medical Case Reports

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Giant right atrium (RA) is a rare entity often seen during childhood due to congenital anomalies. Limited literature has reported such finding in patients with rheumatic valvular heart disease. Here we present a case of a 68-year-old female with a history of rheumatic valve disease treated with a Starr Edwards mechanical ball-in-cage mitral valve replacement and tricuspid valve annuloplasty ring procedures. The patient developed heart failure and had multiple hospital admissions over three decades for heart failure exacerbations mostly triggered by medication and dietary non-compliance. She eventually developed a giant RA that filled most of her thorax. This case demonstrates an extreme form of cardiac remodeling caused by long-term rheumatic valvular heart disease.

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Section: Discussionmentioning

confidence: 99%

Giant right atrium: a long-term complication of rheumatic heart disease

Abugroun

Taha

Daoud

et al. 2020

Oxford Medical Case Reports

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“…In the event of persistent or frequent recurrent PSVT, this process can eventually lead to apoptosis of myocardial cells and fibrosis, resulting in permanent structural changes of the atria . One of the frequent structural changes seen in patients with atrial cardiomyopathy is left atrial enlargement, which is known to provoke stasis of blood flow and increase the risk of thrombus formation . In addition, atrial fibrosis is associated with poor atrial contractility, which would further promote stagnation of the flow.…”

Section: Discussionmentioning

confidence: 99%

“…21 One of the frequent structural changes seen in patients with atrial cardiomyopathy is left atrial enlargement, 22,23 which is known to provoke stasis of blood flow and increase the risk of thrombus formation. 24 In addition, atrial fibrosis is associated with poor atrial contractility, [25][26][27] which would further promote stagnation of the flow.…”

Section: Discussionmentioning

confidence: 99%

Paroxysmal supraventricular tachycardia and risk of ischemic stroke: A systematic review and meta‐analysis

Rujirachun

Wattanachayakul

Winijkul

et al. 2019

Journal of Arrhythmia

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Background Paroxysmal supraventricular tachycardia (PSVT) has been traditionally considered as a benign rhythm disorder. However, recent studies have suggested that patients with PSVT may have a higher risk of ischemic stroke although the data are limited and inconclusive. The current systematic review and meta‐analysis was conducted with the aims to identify all available studies and summarize their results together to better characterize the risk of ischemic stroke among patients with PSVT. Methods A comprehensive literature review was conducted by searching for published articles indexed in MEDLINE and EMBASE databases from inception through November 11, 2018 to identify all observational studies that compared the risk of ischemic stroke between patients with PSVT and individuals without PSVT. Pooled risk ratio (RR) and 95% confidence interval (CI) were calculated using a random‐effect, generic inverse variance method of DerSimonian and Laird. Results A total 5 studies (4 cohort studies and 1 case‐control study) with 4 886 977 participants met the eligibility criteria and were included into the meta‐analysis. The risk of ischemic stroke among patients with PSVT was significantly higher than individuals without PSVT with the pooled RR of 2.03 (95% CI, 1.22‐3.38, I 2 = 89%). Conclusion This study found that PSVT is associated with a higher risk of ischemic stroke. Whether this association is causal and how it should be addressed in clinical practice require further investigations.

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“…Giant left atrium (GLA) is a rare condition closely associated with rheumatic mitral valve disease, seen in only 3%–4% of patients with rheumatic valvular heart disease. 1 The atrial cut-off size for defining GLA differs among investigators; 1 , 2 however, an anterior-posterior dimension of 65 mm is commonly used in the literature. 2 – 4 Because of the location of the left atrium, as it increases in size, adjacent organs may be compressed, resulting in complications.…”

Section: Introductionmentioning

confidence: 99%

Giant left atrium with left lung damage: a case report

Ming-feng

Zhang

2018

J Int Med Res

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Giant left atrium is most commonly associated with rheumatic mitral valve disease, causing a series of cardiac and extracardiac complications. Cardiac complications are often reported, such as atrial fibrillation, decreased cardiac output, and atrial thrombus formation. Extracardiac complications are rarely described in the literature. We report an unusual case of a 55-year-old woman who was diagnosed with rheumatic heart disease 20 years earlier. Her chief complaints were episodes of chest tightness and difficulty breathing, which she had for more than 30 years. Echocardiography showed severe mitral stenosis with severe mitral insufficiency. Contrast-enhanced chest CT showed that the left thoracic cavity was occupied by a giant left atrium. The left main bronchus was compressed, and the left lung showed complete consolidation without pulmonary function.

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Giant left atrium associated with massive thrombus formation

Cited by 13 publications

References 16 publications

Giant right atrium: a long-term complication of rheumatic heart disease

Giant right atrium: a long-term complication of rheumatic heart disease

Paroxysmal supraventricular tachycardia and risk of ischemic stroke: A systematic review and meta‐analysis

Giant left atrium with left lung damage: a case report

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