Giant Multilocular Prostatic Cystadenoma

Maluf, Horacio; King, Mary Etta; Deluca, F; Navarro, J Sevil; Talerman, Aleksander; Young, Robert H.

doi:10.1097/00000478-199102000-00005

Cited by 46 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…No previous studies have reported a diagnosis of giant multilocular prostatic cystadenoma preoperatively by biopsy, and biopsy showed benign prostatic glands and stroma in some reports. The biopsy sample of the tumor in our case showed a spindle cell tumor with focal smooth muscle differentiation [2, 24]. If we could diagnose multilocular prostatic cystadenoma before surgery, that is, if we could suspect that the tumor originated from prostate, we might be able to preserve a normal prostate without prostatic urethra injury.…”

Section: Discussionmentioning

confidence: 91%

“…A giant multilocular prostatic cystadenoma is an extremely rare benign neoplasm that originates in the prostate glands. In 1991, Maluf et al became the first to describe and designate this rare entity [2]; since then, fewer than 30 cases have been reported (Table 1) [1–21]. This type of tumor is typically located along the midline between the bladder and rectum and identified as a large retroperitoneal mass.…”

Section: Discussionmentioning

confidence: 99%

“…Histologically, a giant multilocular prostatic cystadenoma is composed of multiple cysts in hypocellular fibrous stromal tissue and dense fibrous stroma that corresponds to a focal solid area. It is characterized by cuboidal cells lining the prostate glands and cyst, with positive immunohistochemical staining for PSA in epithelial cells [2]. No previous studies have reported a diagnosis of giant multilocular prostatic cystadenoma preoperatively by biopsy, and biopsy showed benign prostatic glands and stroma in some reports.…”

Section: Discussionmentioning

confidence: 99%

“…However, adherence to surrounding structures often makes complete resection difficult, and clinical suspicion of malignancy may lead to unnecessarily aggressive surgery and no preservation of urogenital or digestive organs. Despite its benign nature, incomplete resection can result in recurrence [2, 12]. To achieve complete resection, we sacrificed the rectum as well as the left hypogastric nerve and left pelvic plexus, but were able to preserve adjacent organs including the prostate, which resulted in no urinary disorders or sexual dysfunction.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Giant multilocular prostatic cystadenoma

Nakamura¹,

Shida

Shibayama

et al. 2019

World J Surg Onc

View full text Add to dashboard Cite

Background The giant multilocular prostatic cystadenoma is a very rare benign tumor of the prostate gland. It is composed of predominantly cystic enlarged prostatic glands in a fibrous stroma and spreads extensively into the pelvis. Because of the large size at the time of diagnosis, it is not always possible to determine the exact point of origin for these multilocular cystic neoplasms. Thus, diagnosis before histological examination of a surgical specimen is often difficult. Here, we present a case involving one of the largest giant multilocular prostatic cystadenomas reported in the literature and discuss preoperative diagnoses and appropriate surgical approaches for this rare retroperitoneal tumor. Case presentation A 50-year-old man presented with a 2-year history of abdominal distension and lower urinary symptoms. Enhanced CT showed a large retroperitoneal mass with multiple septations in the pelvis and lower abdomen, measuring 30 cm in size, surrounding the rectum and displacing the bladder, prostate, and seminal vesicle to the right anterior side. MRI showed multiple cysts with a simple fluid appearance on T2-weighted images and enhanced solid components on gadolinium-enhanced fat-saturated T1-weighted images, suggesting the retroperitoneal mass as leiomyoma with cystic degeneration or perivascular epithelioid cell tumor. Biopsy of the mass showed a spindle cell tumor with focal smooth muscle differentiation. Differential diagnosis comprising leiomyoma, low-grade leiomyosarcoma, and perivascular epithelioid cell tumor was made. Complete resection of the tumor with low anterior resection of the rectum was performed. The tumor was solid with multilocular cavities containing blackish-brown fluid and measured 33 × 23 × 10 cm. Histologically, the tumor was composed of variously sized dilated glandular structures lined by prostatic epithelia surrounded by fibromuscular stroma. The prostatic nature of the lesions was confirmed by immunohistochemical staining of the epithelium for prostate-specific antigen. Thus, pathological diagnosis was a giant multilocular prostatic cystadenoma. Conclusions We present our experiences with one of the largest giant multilocular prostatic cystadenomas. When a retroperitoneal huge lesion with locular cavities fills the pelvis in a male patient, the possibility of giant multilocular prostatic cystadenoma should be considered before planning for retroperitoneal tumor treatment.

show abstract

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Giant multilocular prostatic cystadenoma

Nakamura¹,

Shida

Shibayama

et al. 2019

World J Surg Onc

View full text Add to dashboard Cite

show abstract

Malignant cystic epithelial‐stromal tumor of the prostate

Hessel¹,

Reyes

Jensen

et al. 1993

Diagnostic Cytopathology

View full text Add to dashboard Cite

A huge cystic tumor in the pelvis of a 62-year old man, cytologically by fine needle aspiration biopsy, was composed of malignant spindle cells and transitional as well as glandular epithelial cells. Histochemical, immunostaining, and ultrastructural studies of the aspirated specimens and on the radically resected tumor indicated that the neoplastic cells are of prostatic fibroleiomyomatous stromal and epithelial origin. The lesion did not extend to the urothelium of the urinary bladder. This tumor resembles the rare cystadenoleiomyofibroma of the prostate, yet the cytologic abnormalities suggest a malignant potential. Long-term follow-up and recognition of additional cases are necessary to define the biologic behavior of this neoplasm.

show abstract