Giant Polyposis Ulcerative Colitis Imitating Colonic Carcinoma: Two Cases

Giant Pseudopolyposis in Inflammatory Bowel Disease

“…Pseudopolyp is a common association of ulcerative colitis, occurring in 10-20% of patients, with a predilection for the transverse and left colon. [1][2][3][4]10,32 Apart from ulcerative colitis (Table 1), pseudopolyps may also be associated with Crohn's colitis ( Table 2), infective 2 and ischaemic colitis. 8,9 While it is more likely to occur in severe extensive disease, 1 it may be found in both active and quiescent phases of the underlying disease.…”

“… 10 More than 70 cases of giant pseudopolyposis associated with inflammatory bowel disease have been reported. 2,4–7,10–42 The presence of pseudopolyps per se does not reflect the severity of the underlying inflammatory bowel disease and may be found in both active and quiescent phases of ulcerative colitis. 2 The reported duration of ulcerative colitis and Crohn’s colitis, in whom pseudopolyposis is found, ranges, respectively, from 1 month to 20 years (median, 5 years) 2,4,10–34 and 3 months to 37 years (median, 6 years).…”

“… 2,4–7,10–42 The presence of pseudopolyps per se does not reflect the severity of the underlying inflammatory bowel disease and may be found in both active and quiescent phases of ulcerative colitis. 2 The reported duration of ulcerative colitis and Crohn’s colitis, in whom pseudopolyposis is found, ranges, respectively, from 1 month to 20 years (median, 5 years) 2,4,10–34 and 3 months to 37 years (median, 6 years). 4–7,15,17,20,25,29,35–42 Diagnostic problems may arise with the identification of a giant pseudopolyp in a patient with quiescent disease, particularly when the surrounding mucosa reveals minimal evidence of inflammatory bowel disease.…”

Colocolonic Intussusception of a Giant Pseudopolyp in a Patient With Ulcerative Colitis

“…Of greatest concern is the difficulty in distinction from carcinoma. 9,10 This is especially relevant when treating patients with IBD who are at increased risk of developing a malignancy. 11 While giant pseudopolyps generally do not appear to have malignant potential, 8,12,13 occult malignancy within a giant pseudopolyp has been reported.…”

Localized giant inflammatory polyposis of the cecum associated with distal ulcerative colitis

“…[1][2][3] Surgical intervention has often been indicated for such giant inflammatory lesions because of their tumor-like appearance and indefinite diagnosis. [3][4][5] In a recent study, however, magnifying colonoscopy was shown to distinguish such inflammatory polyposis from neoplastic lesions. 6 Here, we report a case of localized giant inflammatory polyposis (LGIP) which underwent marked regression during the course of a 3-year follow-up without surgery.…”