Giant primary amyloidoma of the tonsil

Amado, Manuel López; Patiño, María José Lorenzo; Blanco, Gonzalo; Monreal, F. Arnal

doi:10.1017/s0022215100134413

Cited by 20 publications

(12 citation statements)

References 14 publications

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“…From previous investigations, it appears that the tonsils and lymph nodes are mainly affected by AL amyloidosis and only occasionally by other forms, such as AA amyloidosis (15 versus two characterized cases) [2,8,20,25,33,34,49]. This may be due partly to the underlying disease which, as in our case, showed involvement of the lymphatic tissue and deposition of amyloid at the site of tumor progression.…”

Section: Pathologic Findingssupporting

confidence: 54%

“…Amyloid deposited in lymphatic tissue has been described (rarely) in the tonsil [2,6,7,10,14,26,31], is observed more frequently in lymph nodes and may be present in 6-23% of cases with generalized amyloidosis [8,20,25,33,34,36,38,49]. From previous investigations, it appears that the tonsils and lymph nodes are mainly affected by AL amyloidosis and only occasionally by other forms, such as AA amyloidosis (15 versus two characterized cases) [2,8,20,25,33,34,49].…”

Section: Pathologic Findingsmentioning

confidence: 99%

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Plasmacytoma of the tonsil with AL amyloidosis: evidence of post-fibrillogenic proteolysis of the fibril protein

et al. 2000

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We report of a 58-year-old Caucasian man who was referred to the University Hospital with a greatly enlarged left tonsil which showed calcifications on computed-tomography scans. Histopathology revealed a plasmacytoma with secondary AL amyloidosis, ossifications, and multinucleated foreign-body-type giant cells. N-terminal sequencing of amyloid-fibril proteins purified from the formalin-fixed tissue showed the presence of two proteins of different size; these were of lambda-light-chain origin (subgroup V), measured approximately 15.2 kDa and 10.5 kDa, and had identical N-terminal ends (YVLTQPP). When the amyloid deposits were immunolabeled with a polyclonal antibody directed against lambda light chain, they showed two staining patterns: some deposits showed intense immunolabeling while others were not immunoreactive. Immunostaining of amyloid was completely absent after protease pre-treatment. Immunoelectron microscopy with gold-labeled secondary antibodies showed staining that was spatially related to amyloid fibrils and suggested that the antibody probably detected the fibril protein. Therefore, our hypothesis in this case is that the different immunostaining patterns are due to a post-fibrillogenic proteolysis of the fibril protein at the C-terminal end of the light chain, as indicated by the presence of two differently sized lambda-light-chain fragments with identical N-terminal ends.

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Section: Pathologic Findingssupporting

confidence: 54%

Section: Pathologic Findingsmentioning

confidence: 99%

Plasmacytoma of the tonsil with AL amyloidosis: evidence of post-fibrillogenic proteolysis of the fibril protein

et al. 2000

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“…In the head and neck, amyloidosis may involve the nose 3 , paranasal sinuses 3,4 , nasopharynx, oropharynx, tonsils 5,6 , oral cavity, tongue, tracheobronchial tree and larynx. The larynx is the most usually involved site, and according to Mitrani 7 , in a descending order of prevalence, it involves: ventricular folds (55%), laryngeal ventricle (36%), subglottic space (36%), vocal folds (27%), aryepiglottic folds (23%) and anterior commissure (14%).…”

Section: Discussionmentioning

confidence: 99%

“…In the literature, the most reported symptom of patients with laryngeal amyloidosis is hoarseness 1 , and dysphagia 12 , common in cases of amylolytic macroglossia, rarely described 2,5 .…”

Section: Discussionmentioning

confidence: 99%

Amiloidose com múltiplos focos em trato aéreo-digestivo superior: relato de caso e revisão de literatura

Passerotti¹,

Caniello²,

Hachiya³

et al. 2008

Rev. Bras. Otorrinolaringol.

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Há na literatura inúmeras descrições de amiloidose limitada à laringe, sendo que esta afecção corresponde a cerca de 1% dos tumores benignos da laringe. Entretanto, há somente três relatos de amiloidose acometendo a região do anel de Waldeyer. Descreveremos um raro caso de amiloidose em que há acometimento de sítios distintos do trato aéreo-digestivo superior: pilar amigdaliano, rinofaringe, supraglote e glote, sem continuidade aparente do tecido amilóide. Abordaremos, também, o seguimento pós-operatório com uma disfagia grave.

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“…El término "amiloidosis" incluye un conjunto de diversas enfermedades caracterizadas por la presencia de depósitos extracelulares amorfos eosinofílicos de fibrillas de proteínas que expresan birrefringencia verde manzana bajo luz polarizada después de la tinción con Rojo Congo (1).…”

Section: Introductionunclassified

Amiloidosis primaria localizada en amígdalas palatinas: presentación de caso infrecuente

Gómez-Villa

Valle

Ruiz-Cáez

et al. 2018

Acta otorrinolaringol cir cabeza cuello

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Introducción: La amiloidosis es una enfermedad poco frecuente, caracterizada por la presencia de depósitos extracelulares de agregados fibrilares de amiloide en órganos vitales, causando cambios estructurales y funcionales del tejido, puede ser primaria o secundaria, localizada o generalizada. En cabeza y cuello es una entidad muy rara y casi siempre se presenta en su forma localizada; siendo la laringe, el sitio másfrecuente de presentación. Objetivo: Presentar el caso de una paciente femenina de 62 años con historia de disfonía, en quien se diagnosticó amiloidosis en amígdalas y realizar una breve revisión de esta enfermedad. Diseño: Reporte de caso. Materiales y métodos: Se presenta el caso de una paciente de 62 años con historia de disfonía,el examen físico reveló amígdalas aumentadas de tamaño y dolorosas. Se le realizó amigdalectomía bilateral. Se diagnosticó amiloidosis en amígdalas mediante estudio histopatológico con tinción de Rojo Congo e inmunohistoquímica. Resultados: Se descartó amiloidosis sistémica, dado que todos los estudios realizados para ésta resultaron negativos, los niveles séricos de inmunoglobulinas, paraproteinas, estudioshematológicos y seguimiento clínico hasta la fecha fueron normales, confirmando el diagnóstico de amiloidosis localizada en las amígdalas. Conclusiones: Es importante el estudio histopatológico e inmunohistoquímico para la realización del diagnóstico definitivo de esta patología. Además a todos los pacientes con diagnóstico de amiloidosis localizada en las amígdalas es indispensable realizar estudios hematológicos, detección de proteínas y seguimiento de los órganos blanco para descartar compromiso sistémico e impactar tempranamente en el pronóstico de los pacientes con esta enfermedad.

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Giant primary amyloidoma of the tonsil

Cited by 20 publications

References 14 publications

Plasmacytoma of the tonsil with AL amyloidosis: evidence of post-fibrillogenic proteolysis of the fibril protein

Plasmacytoma of the tonsil with AL amyloidosis: evidence of post-fibrillogenic proteolysis of the fibril protein

Amiloidose com múltiplos focos em trato aéreo-digestivo superior: relato de caso e revisão de literatura

Amiloidosis primaria localizada en amígdalas palatinas: presentación de caso infrecuente

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