Giant retroperitoneal dedifferentiated liposarcoma in an old man

Qiao, Zhenguo; Zhan, Rui; Pang, Yuanxin; Wu, Jianzhong

doi:10.1016/j.asjsur.2021.05.007

Cited by 4 publications

(7 citation statements)

References 3 publications

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“…[1] Complete surgical resection is the most effective treatment for RPDDL. [6] However, it is sometimes difficult to achieve complete resection in clinical practice, because the tumor is usually large and involves the adjacent vital organs. [1,11] It had been reported that approximately 50% of cases required multiple organs excision to reach complete resection.…”

Section: Discussionmentioning

confidence: 99%

“…Typically, it may reach a large size at diagnosis. [ 1 , 4 , 6 ] Thus, the early diagnosis of RPDDL is an enormous challenge. However, in our opinion, annual health examinations, including physical examination and ultrasound screening, may discover the disease as early as possible, especially for high-risk group aged 60 to 70.…”

Section: Discussionmentioning

confidence: 99%

“…[5,8] Moreover, surgical resection remains the most efficacious treatment modality for RPDDL, while the roles of radiotherapy and chemotherapy have been controversial. [1,2,4,6,[9][10][11] Compared to RPWDL, RPDDL frequently has obvious malignant biological behavior with a tendency to recur following surgical resection, which can often lead to a poor prognosis. [12,13] Therefore, it is of great clinical practice value to summarize the novel cases and review the literature to optimize diagnosis and treatment plan.…”

Section: Introductionmentioning

confidence: 99%

“…The nonspecific symptoms, including abdominal distention or pain, nausea, vomiting and so on, mostly do not appear until tumors are large enough to compress or invade the surrounding vital structures. [ 1 , 4 , 6 ] According to the definition of the World Health Organization, RPLS can be classified into 4 major subtypes: well-differentiated (WDL), dedifferentiated (DDL), myxoid, and pleomorphic. [ 7 ] Among them, retroperitoneal dedifferentiated liposarcoma (RPDDL) represents approximately one-third, about 90% arising de novo and 10% following recurrences of retroperitoneal well-differentiated liposarcoma (RPWDL).…”

Section: Introductionmentioning

confidence: 99%

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Recurrence of locally invasive retroperitoneal dedifferentiated liposarcoma shortly after surgery: A case report and literature review

Hu,

Han,

Yang

et al. 2024

Medicine

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Rationale: Retroperitoneal dedifferentiated liposarcoma (RPDDL) is an uncommon malignancy, which often remains undetected for many years due to having adequate space in the retroperitoneal cavity and lacking clinical manifestations in the early stage of the disease. Surgical procedure is usually used as the first choice for treatment. However, it is prone to local recurrence after the operation, resulting in an unfavorable prognosis. Our aim is to draw useful lessons from the new case and provide some experience for management of the disease. Patient concerns: We describe a 55-year-old male patient who was admitted for a 3-week history of persistent dull ache of the left waist. A large mass of the left upper abdomen was palpated in physical examination. Moreover, the imaging examination revealed that the diameter of the mass was about 21 cm, and some adjacent vital organs were invaded, which brought great challenges to complete surgical resection. Diagnosis: The postoperative pathological results confirmed that the mass was RPDDL with invasion of the surrounding vital structures including pancreas, spleen, left adrenal gland, left kidney, and vasculature with tumor emboli. Interventions: Surgical resection of the mass was performed by our multidisciplinary team. The patient received chemotherapy 1 month after surgery. Outcomes: The effect of chemotherapy seemed to be unsatisfactory. Local multifocal recurrence of the tumor was considered about 2 months after surgery. Finally, he gave up any treatments and died of the disease. Lessons: Regular physical examination and ultrasound screening may detect the disease as early as possible, especially for high-risk group aged 60 to 70, which should be popularized. Incomplete resection, vascular invasion, and interruption of postoperative treatment may lead to an unfavorable prognosis. Therefore, we think that patients with the disease may benefit from complete surgical resection and uninterrupted adjuvant therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Recurrence of locally invasive retroperitoneal dedifferentiated liposarcoma shortly after surgery: A case report and literature review

Hu,

Han,

Yang

et al. 2024

Medicine

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“…Most liposarcomas grow slowly and the huge space in the retroperitoneum and abdominal cavity provides sufficient space for their growth. Giant liposarcomas eventually surround large blood vessels and vital organs ( 8 , 9 ). Retroperitoneal liposarcoma is usually asymptomatic until it is large enough to compress the surrounding organs, and there is no evidence that chemotherapy or radiotherapy improves survival ( 10 , 11 ).…”

Section: Introductionmentioning

confidence: 99%

Challenging surgical treatment of giant retroperitoneal liposarcoma: A case report

et al. 2022

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Liposarcoma is a rare malignant tumor type and surgical resection is the gold standard treatment. The present study reported on the case of a 51-year-old woman who presented with a mass in the left upper abdomen. Computed tomography revealed a 32-cm giant retroperitoneal liposarcoma. Complete tumor resection was performed without the removal of other organs. Postoperative pathological examination indicated retroperitoneal well-differentiated liposarcoma and immunohistochemistry revealed S-100(-), MDM2(+), vimentin(+), CDK4(+), p16(+) and STAT6(+) results. The patient recovered well after the surgery. Complete tumor resection during the first surgery is key to cure liposarcoma. The present case report will be helpful for clinical oncologists to fully understand giant retroperitoneal liposarcoma and treat it accordingly.

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A giant liposarcoma originating from peripancreatic fat tissue with identification using 3D-CT angiography: a case report

Narita,

Kaneko,

Hasegawa

et al. 2024

surg case rep

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Background Liposarcoma originating from peripancreatic fat tissue is extremely rare. This case report presents a surgical case of a giant liposarcoma originating from peripancreatic fat tissue with origin identification using 3-Dimensional Computed Tomography Angiography (3D-CTA). Case presentation A 59-year-old female was referred to our hospital with a giant abdominal tumor. Computed tomography revealed a 34 cm tumor composed of fatty tissue, exerting pressure on the posterior aspect of the pancreas. Suspecting liposarcoma, we planned for surgery. At first, the tumor appeared to be intra-abdominal tumor, based on the identification of the tumor’s feeding artery as a branch of the dorsal pancreatic artery using 3D-CTA, we concluded that the liposarcoma originated from the peripancreatic fat tissue and situated in the retroperitoneum. During surgery, we observed a well-capsulated, elastic, yellowish mass without infiltration into surrounding tissues. We carefully dissected the tumor from the greater omentum and transverse mesocolon while preserving the tumor capsule. We ligated the feeding artery at the border with the pancreatic parenchyma and successfully completed the excision of the tumor. The resected specimen weighted 2620 g and was pathologically diagnosed as a well-differentiated liposarcoma. There was no injury to the tumor’s capsule, and the surgical margins were negative. Conclusions In this report, we present an extremely rare case of a liposarcoma originating in the peripancreatic fat tissue. The use of 3D-CTA was instrumental in identifying the primary site of this giant tumor, enabling us to guide the surgery and achieve complete resection successfully.

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Giant retroperitoneal dedifferentiated liposarcoma in an old man

Cited by 4 publications

References 3 publications

Recurrence of locally invasive retroperitoneal dedifferentiated liposarcoma shortly after surgery: A case report and literature review

Recurrence of locally invasive retroperitoneal dedifferentiated liposarcoma shortly after surgery: A case report and literature review

Challenging surgical treatment of giant retroperitoneal liposarcoma: A case report

A giant liposarcoma originating from peripancreatic fat tissue with identification using 3D-CT angiography: a case report

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