Giant retroperitoneal liposarcoma surgical management

Herrera‐Almario, Gabriel; Cabrera, Laura; Londono‐Schimmer, E. E.; Pedraza, Mauricio

doi:10.1308/rcsann.2021.0101

Cited by 5 publications

(4 citation statements)

References 11 publications

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“…Additionally, they are classified into three grades, I, II, and III, following the grading system established by the French Federation Cancer Centre. The prevalent types are well-differentiated (46%), myxoid/round cell (28%), dedifferentiated (18%), and pleomorphic (8%) [10]. Surgical intervention is paramount for treating well-differentiated RLS since these tumors show negligible response to chemotherapy or radiotherapy [11,12].…”

Section: Discussionmentioning

confidence: 99%

A Case of a Giant Liposarcoma at Binh Dan Hospital

Nguyen,

et al. 2024

Cureus

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Retroperitoneal liposarcomas (RLSs) are uncommon mesenchymal tumors that might present a diagnostic challenge due to their rarity and anatomical location. Despite grossly complete resections, they are commonly linked to a high recurrence rate, necessitating long-term or indefinite follow-up. This report discusses a 59-year-old male patient referred to the Gastrointestinal Department due to chronic abdominal distention, right-sided back pain, and a sizable abdominal mass. The diagnosis was an RLS, and the patient underwent en bloc resection of the mass.

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Section: Discussionmentioning

confidence: 99%

A Case of a Giant Liposarcoma at Binh Dan Hospital

Nguyen,

et al. 2024

Cureus

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“…Although chemoradiotherapy can reduce tumor size and slow tumor growth, there are side effects, and survival and recurrence rates also increase accordingly. Therefore, surgical resection is still the first and only way to cure retroperitoneal tumors ( 2 , 15 ). In particular, for fast-growing malignant tumors, resection improves the survival rate and overall quality of life of patients.…”

Section: Discussionmentioning

confidence: 99%

“…These tumors can show expansile growth in their early stage with no apparent symptoms. Most symptoms are caused by the increase in tumor volume and compression of surrounding tissues, requiring patients to seek medical attention ( 2 ). Large retroperitoneal tumors, generally larger than 10 cm, are rare, especially when complicated by a diaphragmatic hernia.…”

Section: Introductionmentioning

confidence: 99%

Surgical approach for complete resection of giant retroperitoneal liposarcoma with diaphragmatic hernia via ninth rib thoracotomy

Hu,

Wu,

Liu

et al. 2023

Front. Oncol.

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BackgroundResection of a giant retroperitoneal liposarcoma is difficult and technically demanding, especially for large retroperitoneal tumors accompanied by a diaphragmatic hernia. Technically, the open abdominal approach can be time-consuming and difficult to perform, with possible intraoperative complications and other factors bringing psychological and physical difficulties to the patient. This study reports a safe and feasible approach for the complete resection of a large retroperitoneal tumor complicated by a diaphragmatic hernia.MethodsA 58-year-old male patient with persistent upper abdominal pain and distension was treated at a local hospital on 4 July 2022. Computed tomography showed a mixed-density mass on the right retroperitoneum, and liposarcoma was considered. On 6 July 2022, the patient was transferred to our hospital for further treatment. Computed tomography showed a mass with low-density fatty shadow in the right adrenal region. The boundary with the right adrenal gland was unclear. The mass was 102 mm × 74 mm, and the right lobe of the liver was compressed. Insufficiency of the right middle lobe of the liver was seen due to a right diaphragmatic hernia and left mediastinal deviation. We considered the traditional approach for tumor resection via laparotomy, but we opted to perform a comprehensive evaluation first. The tumor was close to the back of the right kidney and liver, causing the diaphragm to rise because of its proximity to these organs. Exposing the tumor through laparotomy would be difficult, making it challenging to remove. The patient had a diaphragmatic hernia and moderate pulmonary dysfunction; therefore, we decided to enter the abdomen through a thoracotomy of the ninth rib.ResultsUsing our technique, the tumor was easily visualized and completely removed in approximately 30 min. The intraoperative blood loss was 100 ml, and no postoperative bleeding, pneumothorax, intestinal fistula, infection, or other complications occurred.ConclusionThe transthoracic approach may be a safer and more feasible resection method than the traditional open approach for patients with giant retroperitoneal liposarcoma with a diaphragmatic hernia.

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“…Typically diagnosed in middle-aged and older individuals, the incidence of liposarcomas has exhibited an upward trend over the years [ 7 ]. As liposarcomas advance, they tend to encase blood vessels and major organs, particularly in the retroperitoneal area [ 8 , 9 ]. Often asymptomatic initially, symptoms manifest when the tumor reaches a considerable size, exerting pressure on adjacent tissues and organs.…”

Section: Introductionmentioning

confidence: 99%

Retroperitoneal liposarcoma: unveiling diagnostic delays and multimodal treatment dilemmas

Vlasceanu,

Soroceanu,

Timofte

2023

Arch Clin Cases

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Liposarcomas are a prevalent subtype of soft tissue sarcomas, constituting less than 1% of all malignancies. Originating in the adipose tissue, they can manifest in various locations and are categorized by the World Health Organization into several subtypes: well-differentiated liposarcomas, dedifferentiated liposarcomas, myxoid liposarcomas, pleomorphic liposarcomas and mixed-type liposarcomas . These tumors typically affect middle-aged and older individuals, and their incidence has been progressively increasing over the years. As liposarcomas advance they tend to encase blood vessels and major organs, particularly in the retroperitoneal area. Often asymptomatic initially, symptoms arise as the tumor reaches a considerable size, exerting pressure on adjacent tissues and organs. This report features a 54-year-old patient incidentally diagnosed with a substantial retroperitoneal tumor extending to the antero-lateral abdominal wall and inner thigh via the right inguinal ligament. The patient, with a previous three-year history of a right inguinal mass, sought acute care for a perianal abscess The histological examination revealed morphological aspects consistent with a low-grade myxoid liposarcoma. While surgery remains the primary treatment for retroperitoneal liposarcomas, controversies exist regarding the role of radiotherapy and chemotherapy in improving survival rates. This case highlights the challenges in managing retroperitoneal tumors and underscores the importance of a personalized, multidisciplinary approach to optimize patient outcomes.

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Giant retroperitoneal liposarcoma surgical management

Cited by 5 publications

References 11 publications

A Case of a Giant Liposarcoma at Binh Dan Hospital

A Case of a Giant Liposarcoma at Binh Dan Hospital

Surgical approach for complete resection of giant retroperitoneal liposarcoma with diaphragmatic hernia via ninth rib thoracotomy

Retroperitoneal liposarcoma: unveiling diagnostic delays and multimodal treatment dilemmas

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