Ginger alleviates hyperglycemia-induced oxidative stress, inflammation and apoptosis and protects rats against diabetic nephropathy

Hroob, Amir M. Al; Abukhalil, Mohammad H.; Alghonmeen, Reham D.; Mahmoud, Ayman M.

doi:10.1016/j.biopha.2018.06.148

Cited by 138 publications

(118 citation statements)

References 61 publications

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“…Being one of the most frequently and heavily consumed natural dietary component, ginger and its polyphenolic compounds; zingerone, [6]-gingerol, and shogaol; have been reported for their chemoprotective and antioxidant effects in carcinogenesis (Chung et al, 2001;Mohd-Yusof et al, 2002;Manju and Nalini, 2005). Having more profound effect than gingerols, its active components, (Mukkavilli et al, 2014); researchers highlight the importance of utilizing entire ginger extract over its active components (Prasad and Tyagi, 2015b) with recently reported anti-oxidant, anti-inflammatory and anti-apoptotic effects of whole ginger rhizome extract in rat model of diabetic nephropathy (Al Hroob et al, 2018) Nitrosamines as dietary carcinogens are associated with the etiology of HCC and contribute to the development of oxidative stress, chronic inflammation, and cellular proliferation in response to tissue injury, leading to hepatocarcinogenesis (Darvesh and Bishayee, 2013).…”

Section: Discussionmentioning

confidence: 99%

The Carcinogenic Agent Diethylnitrosamine Induces Early Oxidative Stress, Inflammation and Proliferation in Rat Liver, Stomach and Colon: Protective Effect of Ginger Extract

Mansour

Abdallah

Ibrahim

et al. 2019

Asian Pac J Cancer Prev

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Background:Diethylnitrosamine (DENA), a well-known dietary carcinogen, related to cancer initiation of various organs. The present study investigated the deleterious mechanisms involved in the early destructive changes of DENA in different organs namely, liver, stomach and colon and the potential protective effect of GE against these mechanisms. Methods:Adult male albino rats were assigned into four groups. A normal control group received the vehicle, another group was injected with a single necrogenic dose of DENA (200 mg/kg, i.p) on day 21. Two groups received oral GE (108 or 216 mg/kg) daily for 28 days. Sera, liver, stomach and colon were obtained 7 days after DENA injection. Serum aspartate transaminase and alanine transaminase were detected as well as reduced glutathione (GSH), malondialdehyde, nitric oxide metabolites, interleukin 1β, tumor necrosis factor (TNF-α), alpha-fetoprotein (AFP) and nuclear factor-erythroid 2-related factor2 (Nrf2) in liver, stomach and colon. Histopathological studies and immunohistochemical examination of cyclooxygenase-2 (COX2) were conducted.Results:DENA induced elevation in liver function enzymes with significant increase in oxidation and inflammation biomarkers and AFP while decreased levels of Nrf2 in liver, stomach and colon were detected. Histologically, DENA showed degenerative changes in hepatocytes and inflammatory foci. Inflammatory foci displayed increased expression of COX2 in immunohistochemical staining. GE-pretreatment improved liver function and restored normal GSH with significant mitigation of oxidative stress and inflammatory biomarkers compared to DENA-treated group. AFP was reduced by GE in both doses, while Nrf2 increased significantly. Histology and immunostaining of hepatic COX-2 were remarkably improved in GE-treated groups in a dose dependent manner. Conclusion:GE exerted a potential anti-proliferative activity against DENA in liver, stomach and colon via Nrf2 activation, whilst suppression of oxidation and inflammation.

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Section: Discussionmentioning

confidence: 99%

The Carcinogenic Agent Diethylnitrosamine Induces Early Oxidative Stress, Inflammation and Proliferation in Rat Liver, Stomach and Colon: Protective Effect of Ginger Extract

Mansour

Abdallah

Ibrahim

et al. 2019

Asian Pac J Cancer Prev

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“…Generally, ginger roots (rhizomes) are widely used as a food spice (Eliopoulos, ). In addition, it is commonly used in traditional medicine because of its inherited and evidence‐based health benefits in wide‐range of diseased conditions/disorders such as cancers (Chen et al, ; Saha et al, ; Salafzoon, Mahmoodzadeh Hosseini, & Halabian, ), diabetes (Al Hroob, Abukhalil, Alghonmeen, & Mahmoud, ; Zhu, Chen, Song, Wang, & Sun, ), cardiovascular disease (Liu et al, ; Nicoll & Henein, ), male infertility (Banihani, ; Hosseini et al, ), ulcer (Liu et al, ; Wang et al, ), depression (Kukula‐Koch et al, ), rheumatoid arthritis (Funk, Frye, Oyarzo, & Timmermann, ), Alzheimer (Cuya, Baptista, Franca, & T., ) and nonalcoholic fatty liver disease (Sahebkar, ). In actual fact, the impact of ginger on human health is attributable to its potent bioactive properties such as antioxidant (Danwilai, Konmun, Sripanidkulchai, & Subongkot, ; Masuda, Kikuzaki, Hisamoto, & Nakatani, ), anti‐inflammatory (Jeena, Liju, & Kuttan, ), immuno‐modulatory (Ali, Blunden, Tanira, & Nemmar, ), antimicrobial (Park, Bae, & Lee, ) and anti‐tumorigenic properties (Ali et al, ).…”

Section: Introductionmentioning

confidence: 99%

Effect of ginger (Zingiber officinale) on semen quality

Banihani

2019

Andrologia

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To date, according to the Scopus database, the biological effects of ginger (binominal name: Zingiber officinale), or ginger extracts, and its derived compounds on semen quality and sperm parameters have been revealed in more than 35 original articles. Though, still, there are no collective systematic or narrative discussion and conclusion of this specific research streak. Here, we systematically review and summarise the current link between ginger and its bioactive compounds with semen quality. To achieve this, we searched the central databases (Scopus and PubMed) for original studies, published in English language from August 2004 through February 2019 using the keywords “ginger” versus “sperm” and “semen.” In summary, there is solid evidence that ginger enhances semen quality and improves the main sperm parameters such as concentration, viability, motility and morphology. Such beneficial effects of ginger on semen quality are attributable, at least in part, to increased levels of gonadal hormones, in particular, testosterone and luteinising hormone, decreased oxidative damage to cells, increased production of nitric oxide, hypoglycaemic response of ginger and the presence of valued nutrients in ginger such as manganese. Still, the positive effects of ginger on semen quality require additional approval in men.

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“…Previously, ginger has reported hypolipidemic effects [33,34], however, GG03 did not show this feature among its activity. Still, the main aim when managing diabetes type 1 remains glycemic control-to avoid complications such as diabetic neuropathies-which is mostly achieved by insulin regulation.…”

Section: Discussionmentioning

confidence: 80%

“…The anti-hyperglycemic effect of ginger has been previously reported in STZ-diabetic induced rats [34][35][36][37]. Thus, we evaluated the activity of GG03 on blood glucose levels in STZ-induced diabetic mice.…”

Section: Discussionmentioning

confidence: 94%

Steamed Ginger May Enhance Insulin Secretion through KATP Channel Closure in Pancreatic β-Cells Potentially by Increasing 1-Dehydro-6-Gingerdione Content

et al. 2020

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Ginger (Zingiber officinale Roscoe) and its active compounds (gingerols, shogaols and paradols) have been reported as having beneficial functions for several diseases, including diabetes. In this study, we revealed that the steaming process could enhance the anti-diabetic potential of ginger. To confirm the anti-diabetic effect of steamed ginger extract (GG03), we assessed pancreatic islets impaired by alloxan in zebrafish and demonstrated anti-hyperglycemic efficacy in a mouse model. The EC50 values of ginger extract (GE) and GG03 showed that the efficacy of GG03 was greater than that of GE. In addition, LC50 values demonstrated that GG03 had lower toxicity than GE, and the comparison of the Therapeutic Index (TI) proved that GG03 is a safer functional food. Furthermore, our data showed that GG03 significantly lowered hyperglycemia in a diabetic mouse model. HPLC was performed to confirm the change in the composition of steamed ginger. Interestingly, GG03 showed a 375% increase in 1-dehydro-6-gingerdione (GD) compared with GE. GD has not yet been studied much pharmacologically. Thus, we identified the protective effects of GD in the damaged pancreatic islets of diabetic zebrafish. We further assessed whether the anti-diabetic mechanism of action of GG03 and GD involves insulin secretion. Our results suggest that GG03 and GD might stimulate insulin secretion by the closure of KATP channels in pancreatic β-cells.

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Ginger alleviates hyperglycemia-induced oxidative stress, inflammation and apoptosis and protects rats against diabetic nephropathy

Cited by 138 publications

References 61 publications

The Carcinogenic Agent Diethylnitrosamine Induces Early Oxidative Stress, Inflammation and Proliferation in Rat Liver, Stomach and Colon: Protective Effect of Ginger Extract

The Carcinogenic Agent Diethylnitrosamine Induces Early Oxidative Stress, Inflammation and Proliferation in Rat Liver, Stomach and Colon: Protective Effect of Ginger Extract

Effect of ginger (Zingiber officinale) on semen quality

Steamed Ginger May Enhance Insulin Secretion through KATP Channel Closure in Pancreatic β-Cells Potentially by Increasing 1-Dehydro-6-Gingerdione Content

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