Ginger and turmeric lipid-solubles attenuate heated oil-induced cardio-hepatic oxidative stress via the up-regulation of nuclear factor erythroid 2-related factor 2 and decrease blood pressure in rats

Abstract

Deep-fried vegetable oils are reused multiple times to save costs, and their chronic consumption may cause organ dysfunction. In this study, we assessed the modulatory effects of lipid-solubles from ginger and turmeric that may migrate to oils during heating, on the cardio-hepatic antioxidant defense response, and blood pressure in rats. Male Wistar rats were fed with; 1) control {native canola (N-CNO) or native sunflower (N-SFO)} oil, 2) heated (heated canola {(H-CNO) or heated sunflower (H-SFO)} oil, and 3) heated oil with ginger or turmeric {heated canola with ginger (H-CNO+GI) or heated canola oil with turmeric (H-CNO+TU), heated sunflower oil with ginger (H-SFO+GI) or heated sunflower oil with turmeric (H-SFO+TU)} for 120 days. Oxidative stress markers, antioxidant enzymes, NOS2, ICAM-1, NRF-2, markers of hepatic and cardiac function, blood pressure were assessed. Feeding heated oils (H-CNO or H-SFO); 1) increased oxidative stress markers, NOS-2 and ICAM-1 expression, 2) decreased antioxidant enzyme activity and NRF-2 level, 3) increased marker enzymes of hepatic and cardiac function, and 4) increased systolic and diastolic blood pressure significantly (p<0.05), when compared to respective native oils (N-CNO or N-SFO). However, feeding oils heated with ginger or turmeric positively countered the changes induced by heated oils. Consumption of repeatedly heated oil causes cardio-hepatic dysfunction by inducing oxidative stress through NRF-2 downregulation. Lipid-solubles from ginger and turmeric that may migrate to oil during heating, prevent the oxidative stress and blood pressure triggered by heated oils in rats.

Preventive Effects of Sesamol on Deep‐Frying Oil‐Induced Liver Metabolism Disorders by Altering Gut Microbiota and Protecting Gut Barrier Integrity

“…The doses of fresh soybean oil, deep‐frying soybean oil, pre‐add sesamol deep‐frying soybean oil, and sesamol supplementation were selected based on previous research and our preliminary experiments (Figure S1a, Supporting Information). [ 27,48,64–67 ]…”

“…The doses of fresh soybean oil, deep-frying soybean oil, pre-add sesamol deep-frying soybean oil, and sesamol supplementation were selected based on previous research and our preliminary experiments (Figure S1a, Supporting Information). [27,48,[64][65][66][67] Data Analysis: The 16S rRNA sequencing data were analyzed by a Kruskal-Wallis analysis of variance (ANOVA) test to detect significant differences among the different groups. Data were reported as means ± SEM of at least three independent experiments.…”