2019
DOI: 10.1080/01635581.2019.1685113
|View full text |Cite
|
Sign up to set email alerts
|

Ginger extract activates caspase independent paraptosis in cancer cells via ER stress, mitochondrial dysfunction, AIF translocation and DNA damage

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

1
17
0

Year Published

2020
2020
2024
2024

Publication Types

Select...
7
1

Relationship

1
7

Authors

Journals

citations
Cited by 34 publications
(18 citation statements)
references
References 48 publications
1
17
0
Order By: Relevance
“…Although a slight activation of caspase‐3 was observed in the HRC treated cells at 48 h, the DNA fragmentation profile, uncondensed nuclei and status of PS externalization effectively confirmed the nonapoptotic nature of HRC‐induced cell death. This result could be largely rationalized with the findings in paraptosis induced by RuII polypyridyl complex and ginger extract (Nedungadi et al, 2019, Pierroz et al, 2016). These features classify the HRC mediated death as nonapoptotic.…”
Section: Discussionsupporting
confidence: 60%
See 1 more Smart Citation
“…Although a slight activation of caspase‐3 was observed in the HRC treated cells at 48 h, the DNA fragmentation profile, uncondensed nuclei and status of PS externalization effectively confirmed the nonapoptotic nature of HRC‐induced cell death. This result could be largely rationalized with the findings in paraptosis induced by RuII polypyridyl complex and ginger extract (Nedungadi et al, 2019, Pierroz et al, 2016). These features classify the HRC mediated death as nonapoptotic.…”
Section: Discussionsupporting
confidence: 60%
“…HRC, with interchanged position of the double bond was found to be 1.7 times more potent than that its precursor 2′-hydroxychalcone. (Nedungadi et al, 2019, Pierroz et al, 2016. These features classify the HRC mediated death as nonapoptotic.…”
Section: Discussionmentioning
confidence: 99%
“…MMP was fairly maintained in the progression of paraptosis, but its loss was detected at the excessively expanded megamitochondria at the late stage of paraptosis (Lee et al, 2019;Seo et al, 2019). Reduced ATP synthesis is also observed following the extensive vacuolation derived from the mitochondria and/or the ER in paraptosis (He et al, 2018;Binoy et al, 2019;Nedungadi et al, 2019). Therefore, we presume that swelling and fusion of the mitochondria at the pre-lethal phase may provide an adaptive response that helps maintain mitochondrial membrane integrity and function before leading to irreversible paraptotic cell death.…”
Section: Discussionmentioning
confidence: 90%
“…Although the mechanisms of paraptosis, particularly the mechanisms responsible for triggering dilation of mitochondria or the ER, have not yet been entirely clear, paraptosis is usually accompanied by an alteration of Ca 2+ Yoon et al (2012) and redox homeostasis Yoon et al (2010) , as well as by proteostasis disruption Seo et al (2019) and ER stress ( Fabrizio et al, 2019 ; Zhang et al, 2020 ; Nedungadi et al, 2021 ). Ultimately, unfolded/misfolded proteins accumulate in the ER lumen, leading to the activation of pro-death processes.…”
Section: Introductionmentioning
confidence: 99%