We report the application of a chemodosimeter 'turn on' fluorescent probe for detecting endogenous HS formation in cancer cells. Mito-HS showed a bathochromic shift in the UV-vis-absorption spectrum from 355 nm to 395 nm in the presence of HS. Furthermore, it showed an ∼43-fold fluorescence enhancement at λ = 450 nm in the presence of HS (200 μM). The cancer cell-specific fluorescence imaging reveals that Mito-HS has the ability to distinguish cancer cells from normal cells based on the level of endogenous HS formation. In due course, Mito-HS would be a powerful cancer biomarker based on its ability to estimate endogenous HS formation in living cells.

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