Ginger for Healthy Ageing: A Systematic Review on Current Evidence of Its Antioxidant, Anti-Inflammatory, and Anticancer Properties

Özkur, Mehtap; Benlier, Necla; Takan, Işıl; Vasileiou, Christina; Georgakilas, Alexandros G.; Pavlopoulou, Athanasia; Çetin, Zafer; Saygılı, Eyüp İlker

doi:10.1155/2022/4748447

Cited by 46 publications

(30 citation statements)

References 134 publications

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“…In the research of senolytic/senomorphyc compounds, the attention of the scientific community was attracted by natural compounds, used in ancient medicine, known for their beneficial effects and high tolerability. The Asian-native Zingiber officinale Roscoe, commonly known as ginger, has long been widely consumed as a food spice and herbal medicine to treat various symptoms, including vomiting, nausea, and pain [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Zingiber officinale Roscoe Rhizome Extract Exerts Senomorphic and Anti-Inflammatory Activities on Human Endothelial Cells

Matacchione

Borgonetti

Ramini

et al. 2023

Biology

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Aging is related to a low-grade and sterile inflammation called inflammaging, recognized as the main risk factor for age-related disease (ARD) development. Inflammaging is fostered by the repeated activation of immune cells, as well as by the accumulation of senescent cells. Recently, a number of natural compounds have gained attention to be tested as anti-aging therapies, based on their anti-inflammatory activity and/or ability to reduce the pro-inflammatory secretome of senescent cells (senomorphyc activity). Here, we investigated the anti-inflammatory and senomorphic properties of an Asian-native Zingiber officinale Roscoe extract (ZOE), commonly consumed as a food spice and herbal medicine. We employed two models of primary endothelial cells (HUVECs), such as the replicative-senescence and LPS-induced response, to investigate the anti-inflammatory/senomorphic effect of ZOE, and one cellular model of neuroinflammation, i.e., immortalized murine microglial cells (BV2). First, we found that the ZOE treatment induced the inhibition of NF-kB activation in BV2 cells. Among the constituents of ZOE, we showed that the terpenoid-enriched fraction (ZTE) was the component able to counteract the phosphorylation of NF-kB(p65), while 6-gingerol (GIN) and 6-shogaol (SHO) did not produce any significant effect. Further, we observed that the treatment with 10 µg/mL of ZOE exerted anti-inflammatory activity on LPS-stimulated young (y)HUVEC and senomorphyc activity on replicative senescent (s)HUVEC, significantly reducing the expression levels of IL-1β, TNF -α, IL-8, MCP-1, and ICAM-1. Moreover, the ZTE treatment was able to significantly reduce the IL-8 levels secreted in the medium of both LPS-stimulated yHUVEC and sHUVEC. Overall, our data suggest a potential protective role of ZOE on neuroinflammation and endothelial inflammation/activation, thus suggesting its potential relevance in delaying/postponing ARD development and progression, characterized by endothelial dysfunction.

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Section: Introductionmentioning

confidence: 99%

Zingiber officinale Roscoe Rhizome Extract Exerts Senomorphic and Anti-Inflammatory Activities on Human Endothelial Cells

Matacchione

Borgonetti

Ramini

et al. 2023

Biology

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“…Mounting evidence suggests that ginger can promote healthy ageing, reduce morbidity, and prolong a healthy lifespan [6]. It has been demonstrated to possess antioxidant, antiinflammatory, anticancer, and antimicrobial properties, as well as an outstanding antiviral activity due to a high concentration of antiviral compounds.…”

Section: Introductionmentioning

confidence: 99%

The Use of Herbal Health Products and Home-Based Remedies for Protection Against Covid-19

Fagbola¹

2023

TIJPH

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Natural medicinal products and home-based remedies have been in use for centuries by people across the world. Tradition, belief, cultural practice, and previous experience are associated with the use of herbal products. The trend is observed to be on the increase since covid-19 Pandemic hit the global stage. In the early days of the Pandemic, people protected themselves by practicing measures that would safeguard them from getting infected with the deadly virus. This study evaluated prevalence, risks, harms, benefits, and other issues associated with using herbs and home-based remedies to prevent and treat Covid-19. It highlights various measures of prevention and treatment practiced by employees and customers of a Regional Corporation by capturing the demographic characteristics, reasons, and associated factors for using alternative medical products. A descriptive cross-sectional survey in a hybrid online was carried out from February 2022 to April 2022. Data of independent and dependent variables was collected using a well-structured hybrid (online and paper and pencil) questionnaire. Prevalence of steam inhalation was 51%, essential oils, including menthol crystal vapour inhalation, was 61%, herbal supplements was 20.6%, and natural health products was 100% (n = 286). Non-allopathic medicinal products, home-based remedies, and other preventive health measures were on the increase in prevalence during covid-19 Pandemic. Large studies are required to assess the efficacy and safety of herbal supplements and home-based remedies to protect users from unnecessary dangers inherent in their use. Keywords: Covid-19 pandemic, Herbal health supplements, Home-based remedies, Infection, Prevalence, Natural products, Regional corporation.

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“…There are more than 200 identified compounds in ginger, and its bioactive constituents include tannins, anthocyanins, terpenes (e.g., α-zingiberene, β-bisabolene, β-sesquiphellandrene, ar-curcumene, or (E,E)-α-farnesene) and phenolic compounds (gingerols, paradols, shogaols, and zingerone) ( Semwal et al, 2015 ; Koch et al, 2017 ; Mao et al, 2019 ). Gingerols are the major pungent compounds of ginger ( Ozkur et al, 2022 ). Numerous studies have focused on ginger extracts and the phenolic compounds isolated from them, showing that gingerols have various pharmacological effects, mainly 6-gingerol.…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory and anti-inflammatory therapeutic potential of gingerols and their nanoformulations

et al. 2022

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Ginger (Zingiber officinale Roscoe), a member of the Zingiberaceae family, is one of the most popular spices worldwide, known since ancient times, and used both as a spice and a medicinal plant. The phenolic compounds found in ginger are predominantly gingerols, shogaols, and paradols. Gingerols are the major phenolic compounds found in fresh ginger and contain mainly 6-gingerol as well as 4-, 5-, 8-, 10-, and 12-gingerols. Gingerols possess a wide array of bioactivities, such as antioxidant and anticancer, among others. Regarding the different array of biological activities and published data on the mechanisms underlying its action, the complex interaction between three key events, including inflammation, oxidative stress, and immunity, appears to contribute to a plethora of pharmacological activities of this compound. Among these, the immunomodulatory properties of these compounds, which attract attention due to their effects on the immune system, have been the focus of many studies. Gingerols can alleviate inflammation given their ability to inhibit the activation of protein kinase B (Akt) and nuclear factor kappa B (NF-κB) signaling pathways, causing a decrease in proinflammatory and an increase in anti-inflammatory cytokines. However, given their low bioavailability, it is necessary to develop new and more effective strategies for treatment with gingerols. In order to overcome this problem, recent studies have addressed new drug delivery systems containing gingerols. In this review, the immunomodulatory activities of gingerol and its underlying mechanisms of action combined with the contributions of developed nanodrug delivery systems to this activity will be examined.

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Ginger for Healthy Ageing: A Systematic Review on Current Evidence of Its Antioxidant, Anti-Inflammatory, and Anticancer Properties

Cited by 46 publications

References 134 publications

Zingiber officinale Roscoe Rhizome Extract Exerts Senomorphic and Anti-Inflammatory Activities on Human Endothelial Cells

Zingiber officinale Roscoe Rhizome Extract Exerts Senomorphic and Anti-Inflammatory Activities on Human Endothelial Cells

The Use of Herbal Health Products and Home-Based Remedies for Protection Against Covid-19

Immunomodulatory and anti-inflammatory therapeutic potential of gingerols and their nanoformulations

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