Ginger for prevention of antiretroviral-induced nausea and vomiting: a randomized clinical trial

Dabaghzadeh, Fatemeh; Khalili, Hossein; Dashti‐Khavidaki, Simin; Abbasian, Ladan; Moeinifard, Amir

doi:10.1517/14740338.2014.914170

Cited by 28 publications

(17 citation statements)

References 28 publications

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“…[39] Nutraceutical properties of ginger are important to food processing and the pharmaceutical industries. According to the previous studies, [3,40,41] the clinical dosage of ginger was at 0.5-6 g per 70 kg per day (7.14-85.71 mg kg −1 ), therefore, the dosage of 6-Gin was converted at 0.1535-1.843 mg kg −1 . [42] The human equivalent dose of 6-Gin given to the mice (10 and 20 mg kg −1 ) in this study was 0.677-1.354 mg kg −1 based on the formula by Reagan-Shaw et al [43] Therefore, the concentration used in this study was relevant from a nutritional point of view.…”

Section: Discussionmentioning

confidence: 99%

[6]‐Gingerol Ameliorates ISO‐Induced Myocardial Fibrosis by Reducing Oxidative Stress, Inflammation, and Apoptosis through Inhibition of TLR4/MAPKs/NF‐κB Pathway

Han

Liu

et al. 2020

Molecular Nutrition Food Res

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Scope [6]‐Gingerol is one of the primary pungent constituents of ginger. While [6]‐gingerol has many pharmacological effects, its benefits for myocardial fibrosis, including its exact role and underlying mechanisms, remain largely unexplored. The present study is designed to characterize the cardio‐protective effects of [6]‐gingerol in myocardial fibrosis mice and possible underlying mechanisms. Methods and results Mice are subcutaneously injected with isoproterenol (ISO, 10 mg kg−1) and gavaged with [6]‐gingerol (10, 20 mg kg−1 day−1) for 14 days. Pathological alterations, fibrosis, oxidative stress, inflammation response, and apoptosis are examined. In ISO‐induced myocardial fibrosis, [6]‐gingerol treatment decreases the J‐point, heart rate, cardiac weight index, left ventricle weight index, creatine kinase (CK), and lactate dehydrogenase serum levels, calcium concentration, reactive oxygen species, malondialdehyde, and glutathione disulfide (GSSG), and increases levels of superoxide dismutase, catalase, glutathione, and GSH/GSSG. Further, [6]‐gingerol improved ISO‐induced morphological pathologies, inhibited inflammation and apoptosis, and suppressed the toll‐like receptor‐4 (TLR4)/mitogen‐activated protein kinases (MAPKs)/nuclear factor κB (NF‐κB) signaling pathways. Conclusion The protective effect of [6]‐gingerol in mice with ISO‐induced myocardial fibrosis may be related to the inhibition of oxidative stress, inflammation, and apoptosis, potentially through the TLR4/MAPKs/NF‐κB signaling pathway.

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Section: Discussionmentioning

confidence: 99%

[6]‐Gingerol Ameliorates ISO‐Induced Myocardial Fibrosis by Reducing Oxidative Stress, Inflammation, and Apoptosis through Inhibition of TLR4/MAPKs/NF‐κB Pathway

Han

Liu

et al. 2020

Molecular Nutrition Food Res

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“…Still, ginger may have a beneficial effect in gynecological patients, according to the results from Apariman et al, Chaiyakunapruk et al, Phillips et al, and Bone et al [58][59][60][61]. Finally, in the study by Dabaghzadeh et al, the researchers primally examined the effect of ginger and demonstrated its benefit on the prevention of nausea and vomiting induced by an antiretroviral regimen (p = 0.001) [62]. Efficacy on motion sickness and vertigo was also examined in several studies, with results indicating different aspects between the studies.…”

Section: Yesmentioning

confidence: 99%

Ginger on Human Health: A Comprehensive Systematic Review of 109 Randomized Controlled Trials

et al. 2020

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Clinical applications of ginger with an expectation of clinical benefits are receiving significant attention. This systematic review aims to provide a comprehensive discussion in terms of the clinical effects of ginger in all reported areas. Following the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guideline, randomized controlled trials on the effects of ginger were investigated. Accordingly, 109 eligible papers were fully extracted in terms of study design, population characteristics, evaluation systems, adverse effects, and main outcomes. The reporting quality of the included studies was assessed based on the Cochrane Collaboration’s tool for assessing the risk of bias in randomized trials and integrated together with studies that investigated the same subjects. The included studies that examined the improvement of nausea and vomiting in pregnancy, inflammation, metabolic syndromes, digestive function, and colorectal cancer’s markers were consistently supported, whereas other expected functions were relatively controversial. Nevertheless, only 43 clinical trials (39.4%) met the criterion of having a ‘high quality of evidence.’ In addition to the quality assessment result, small populations and unstandardized evaluation systems were the observed shortcomings in ginger clinical trials. Further studies with adequate designs are warranted to validate the reported clinical functions of ginger.

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“…Evidence to support efficacy of ginger in prevention and treatment of chemotherapy‐induced nausea and vomiting is lacking. However, ginger showed promising effect on preventing postoperative nausea and vomiting at least as add‐on therapy (Dabaghzadeh et al ., , ). Efficacy of ginger for prevention of antiretroviral‐induced nausea and vomiting has been recently evaluated, and the results are promising (Dabaghzadeh et al ., , ).…”

Section: Discussionmentioning

confidence: 99%

“…Inhibitory effects of gingerol on some receptors at peripheral and central levels have been suggested as probable mechanisms (Langner et al ., ; Pertz et al ., ; Qian et al ., and Qian et al ., ). Effects of ginger as a partially safe herbal product with minimal clinically significant drug interactions in prevention of postoperative, chemotherapy, and antiretroviral‐induced nausea and vomiting have been evaluated (Mahesh et al ., ; de Pradier, and Dabaghzadeh et al ., , ).…”

Section: Introductionmentioning

confidence: 99%

Ginger for Prevention of Antituberculosis-induced Gastrointestinal Adverse Reactions Including Hepatotoxicity: A Randomized Pilot Clinical Trial

2016

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In this study, the potential benefits of ginger in preventing antituberculosis drug-induced gastrointestinal adverse reactions including hepatotoxicity have been evaluated in patients with tuberculosis. Patients in the ginger and placebo groups (30 patients in each group) received either 500 mg ginger (Zintoma)(®) or placebo one-half hour before each daily dose of antituberculosis drugs for 4 weeks. Patients' gastrointestinal complaints (nausea, vomiting, dyspepsia, and abdominal pain) and antituberculosis drug-induced hepatotoxicity were recorded during the study period. In this cohort, nausea was the most common antituberculosis drug-induced gastrointestinal adverse reactions. Forty eight (80%) patients experienced nausea. Nausea was more common in the placebo than the ginger group [27 (90%) vs 21 (70%), respectively, p = 0.05]. During the study period, 16 (26.7%) patients experienced antituberculosis drug-induced hepatotoxicity. Patients in the ginger group experienced less, but not statistically significant, antituberculosis drug-induced hepatotoxicity than the placebo group (16.7% vs 36.7%, respectively, p = 0.07). In conclusion, ginger may be a potential option for prevention of antituberculosis drug-induced gastrointestinal adverse reactions including hepatotoxicity. Copyright © 2016 John Wiley & Sons, Ltd.

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Ginger for prevention of antiretroviral-induced nausea and vomiting: a randomized clinical trial

Abstract: Ginger was effective in ameliorating of antiretroviral-induced N/V.

Cited by 28 publications

References 28 publications

[6]‐Gingerol Ameliorates ISO‐Induced Myocardial Fibrosis by Reducing Oxidative Stress, Inflammation, and Apoptosis through Inhibition of TLR4/MAPKs/NF‐κB Pathway

[6]‐Gingerol Ameliorates ISO‐Induced Myocardial Fibrosis by Reducing Oxidative Stress, Inflammation, and Apoptosis through Inhibition of TLR4/MAPKs/NF‐κB Pathway

Ginger on Human Health: A Comprehensive Systematic Review of 109 Randomized Controlled Trials

Ginger for Prevention of Antituberculosis-induced Gastrointestinal Adverse Reactions Including Hepatotoxicity: A Randomized Pilot Clinical Trial

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