Ginger polyphenols attenuate cyclosporine-induced disturbances in kidney function: Potential application in adjuvant transplant therapy

Adekunle, Isiaka Ayofe; Imafidon, Christian Eseigbe; Oladele, Ayowole A.; Ayoka, Abiodun Oladele

doi:10.1016/j.pathophys.2018.02.001

Cited by 19 publications

(18 citation statements)

References 43 publications

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“…The restoration of antioxidant levels by AECUL suggests that the extract has potent antioxidant activity, as well as the potential to reduce cellular disruption by chemical agents, as demonstrated by the comparison of TBARS levels. Some of the phytochemicals identified in AECUL, such as flavonoids, phenolics and saponins, have been reported in the literature to have potent antioxidant, anti‐inflammatory and membrane‐stabilizing potential . Therefore, we conclude that the overall pharmacological (including antioxidant) activity of the extract was conferred by the presence of these important phytochemicals.…”

Section: Discussionmentioning

confidence: 63%

“…Reduced glutathione (GSH) is a non‐enzymatic antioxidant marker, while thiobarbituric acid reactive substance (TBARS) is an important index of lipid peroxidation . This study demonstrated that cimetidine administration caused deleterious disturbance of the antioxidant system.…”

Section: Discussionmentioning

confidence: 97%

“…The extraction process for obtaining an acetone extract of C. Longa rhizome (AECUL) followed the standard procedure described by Imafidon et al and Adekunle et al Fresh rhizomes of C. Longa were peeled and weighed. Thereafter, they were crushed in 80% acetone (1:2 w/v) with a Waring blender (Waring Commercial) for 5 minutes.…”

Section: Methodsmentioning

confidence: 99%

“…Acetone was used for the extraction process because it has been reported in the literature to extract high quantities of flavonoids and polyphenols from plant samples. These important phytochemicals have health‐boosting pharmacological activities …”

Section: Methodsmentioning

confidence: 99%

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Curcuma longa normalized cimetidine‐induced pituitary‐testicular dysfunction: Relevance in nutraceutical therapy

Onwuemene

Imafidon

Ayoka

2019

Anim Models and Exp Med

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Background The increasing incidence of chemically induced infertility is both a social threat and a threat to the continuation of life itself. Treatment or management therapy is often expensive. This study investigated the effects of acetone extract of a local plant (Curcuma longa) in a Wistar rat model of cimetidine‐induced pituitary‐testicular dysfunction. Methods Thirty‐five male Wistar rats were divided into 7 groups of 5 rats. After a phytochemical screening of an acetone extract of C. Longa, cimetidine and the extract at three doses, 200, 400 and 600 mg/kg, were orally co‐administered to the rats for 28 consecutive days. Comparisons were made (at P < 0.05) against a control (2 mL/kg distilled water), a standard treatment group (cimetidine + 50 mg/kg vitamin C), a toxic group (60 mg/kg cimetidine) and a group receiving extract alone. Results Cimetidine administration was associated with deleterious alterations to sperm motility, sperm count and sperm viability, as well as derangements in the plasma levels of FSH, LH and testosterone (P < 0.05). Both brain and testicular GSH and TBARS levels were significantly altered following cimetidine administration, and distortions were seen in the pituitary and testicular histoarchitecture. These changes were significantly normalized by co‐administration of graded doses of the extract, with an associated improvement of both pituitary and testicular histology. Conclusion Acetone extract of C. Longa normalized cimetidine‐induced pituitary‐testicular dysfunction in Wistar rats. This presents the extract as a potential nutraceutical choice against chemically induced reproductive toxicity.

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Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 97%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Curcuma longa normalized cimetidine‐induced pituitary‐testicular dysfunction: Relevance in nutraceutical therapy

Onwuemene

Imafidon

Ayoka

2019

Anim Models and Exp Med

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“…Metabolic cages were fabricated by Central Technological Laboratory and Workshops (CTLW), Obafemi Awolowo University (OAU), Ile-Ife, Osun state, Nigeria [3,26].…”

Section: Metabolic Cagesmentioning

confidence: 99%

Aqueous garlic extract improves renal clearance via vasodilatory/antioxidant mechanisms and mitigated proteinuria via stabilization of glomerular filtration barrier

et al. 2019

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Background: Lead (Pb) remains an apparently indispensable material in several industrial processes. It is a potent environmental toxin with associated deleterious biological effects. The study investigated the effects of aqueous garlic extract (AGE) on renal clearance and proteinuria in Wistar rats with Pb-induced kidney injury.Methods: Thirty male Wistar rats were divided into six groups of five rats each such that exposure to Pb (35 mg/kg i.p) for 10 consecutive days was either followed by 30 days recovery period (without treatment) or 30 days post-treatment with oral graded doses of AGE at 100, 200 and 400 mg/kg while comparisons where made against a control (2 ml/kg NORMAL SALINE) at p < 0.05. The phytochemical constituents of the extract were determined using conventional standard protocols before administration to the rats.Results: Pb toxicity induced deleterious alterations of renal function biomarkers (creatinine, urea and total protein) in the plasma and urine, indicators of oxidative stress and lipid peroxidation (GSH, SOD, CAT and TBARS) in the kidney tissues as well as significantly lowered plasma and kidney NO level (p < 0.05) of the rats. It also significantly lowered creatinine clearance and fractional excretion of urea while urine total protein-creatinine ratio was significantly increased in the rats. Kidney histology showed evidence of Pb-induced glomerular atrophy with tubular and interstitial vacuolation. However, AGE administration was associated with significant normalization of the aforementioned biochemical parameters (p < 0.05) as well as kidney histoarchitectural improvement. The pharmacological effects of AGE were attributed to its determined phytochemical constituents. Conclusion: AGE normalized renal clearance through vasodilatory and antioxidant mechanisms with associated mitigation of proteinuria through stabilization of glomerular filtration barrier.

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Ginger: From serving table to salient therapy

et al. 2021

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Ginger polyphenols attenuate cyclosporine-induced disturbances in kidney function: Potential application in adjuvant transplant therapy

Cited by 19 publications

References 43 publications

Curcuma longa normalized cimetidine‐induced pituitary‐testicular dysfunction: Relevance in nutraceutical therapy

Curcuma longa normalized cimetidine‐induced pituitary‐testicular dysfunction: Relevance in nutraceutical therapy

Aqueous garlic extract improves renal clearance via vasodilatory/antioxidant mechanisms and mitigated proteinuria via stabilization of glomerular filtration barrier

Ginger: From serving table to salient therapy

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