Gingival bleeding on probing: relationship to change in periodontal pocket depth and effect of sodium hypochlorite oral rinse

Gonzalez, S.; Cohen, C. L.; Galvan, Monica; Alonaizan, Faisal; Rich, Sandra K.; Slots, Jørgen

doi:10.1111/jre.12219

Cited by 41 publications

(81 citation statements)

References 43 publications

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“…The patients were divided into a test group of 17 who received a sodium hypochlorite rinse, and a control group of 17 who received a water rinse (Tx_Ctl column, Table S1). This treatment has been described elsewhere in detail (25, 32). All study patients received a comprehensive clinical examination at the baseline (visit 1), at day 14 (visit 2), and at month 3 (visit 3).…”

Section: Methodsmentioning

confidence: 99%

“…Samples from individual teeth were analyzed separately. In a few patients, where the previous diseased sample sites became minimally diseased or healthy after therapy (25), other deep pockets in the same dentition were then sampled. For the supragingival sampling, one sample pooled from three teeth with the heaviest plaque accumulation was collected per patient per time point with a sterile periodontal curette.…”

Section: Methodsmentioning

confidence: 99%

“…Specifically, we used these multi-omics techniques to analyze samples in a follow-up to a study investigating the use of 0.25% sodium hypochlorite (diluted bleach) on dental biofilm formation (25). While Gonzales et al (25) demonstrated a significant clinical improvement in periodontal disease during a longitudinal 3-month study, they did not determine whether or not treatment altered the biofilm communities. Using the multi-omics approach, we determined microbial composition, functional gene content, and metabolic profiles at the baseline and how these communities shifted after 2 weeks and 3 months both within and among individuals.…”

Section: Introductionmentioning

confidence: 99%

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Multi-omics Analysis of Periodontal Pocket Microbial Communities Pre- and Posttreatment

et al. 2017

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Periodontal disease affects the majority of adults worldwide and has been linked to numerous systemic diseases. Despite decades of research, the reasons for the substantial differences among periodontitis patients in disease incidence, progressivity, and response to treatment remain poorly understood. While deep sequencing of oral bacterial communities has greatly expanded our comprehension of the microbial diversity of periodontal disease and identified associations with healthy and disease states, predicting treatment outcomes remains elusive. Our results suggest that combining multiple omics approaches enhances the ability to differentiate among disease states and determine differential effects of treatment, particularly with the addition of metabolomic information. Furthermore, multi-omics analysis of biofilm community instability indicated that these approaches provide new tools for investigating the ecological dynamics underlying the progressive periodontal disease process.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Multi-omics Analysis of Periodontal Pocket Microbial Communities Pre- and Posttreatment

et al. 2017

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“…An oral mouthrinse with 0.05% sodium hypochlorite resulted in significant reduction in supragingival biofilm accumulation and gingival inflammation [16]. In subsequent studies twice-weekly rinsing with 0.25% sodium hypochlorite solution decreased dental plaque level and reduced bleeding on probing in periodontal pockets [17,18].…”

Section: Introductionmentioning

confidence: 99%

In-vitro activity of sodium-hypochlorite gel on bacteria associated with periodontitis

et al. 2016

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2Objectives: The aim of the present study was to assess the antimicrobial activity of a sodium hypochlorite formulation incl. its components against bacteria associated with periodontal disease. Materials and Methods:Sodium hypochlorite formulation (NaOCl gel), its components sodium hypochlorite (NaOCl) and the activating vehicle were compared with 0.1% chlorhexidine digluconate (CHX) solution. The antimicrobial activity was proven by determination of minimal inhibitory concentrations (MIC), minimal bactericidal concentrations, and killing assays. Furthermore, the influence on formation as well as on a 4-days old 6-species biofilm was tested.Results: Except for one strain (Parvimonas micra ATCC 33270 in case of NaOCl gel) the MICs both of the CHX solution and NaOCl gel did not exceed 10% of the formulations' concentration. In general MICs of the NaOCl gel were equal as of the CHX solution against Gram-negatives but higher against Gram-positive bacteria. CHX but not NaOCl gel clearly inhibited biofilm formation, however the activity of NaOCl gel was more remarkable on a 4-d old biofilm. NaOCl killed bacteria in the biofilm and interfered with the matrix. Conclusions:The NaOCl gel acts antimicrobial in particular against Gram-negative species associated with periodontitis. Moreover, its component NaOCl hypochlorite is able to alter biofilm matrices.Clinical relevance: The NaOCl gel may represent a potential alternative for adjunctive topical antimicrobial treatment in periodontitis

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“…El hipoclorito de sodio ha sido utilizado en algunos estudios de inhibición de microorganismos subgingivales en bolsas periodontales (Galván et al, 2013;Gonzalez et al, 2015). Concentraciones de hipoclorito de sodio al 0.05% también ha sido utilizado en enjuague bucal para la reducción de la gingivitis en un período de 21 días.…”

Section: áCido Hipocloroso (Hocl) Los Usos Terapéuticos Delunclassified

Ácido Hipocloroso: una Nueva Alternativa como Agente Antimicrobiano y para la Proliferación Celular para Uso en Odontología

Lafaurie

Calderón²,

Zaror

et al. 2015

Int. J. Odontostomat.

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RESUMEN:El ácido hipocloroso (HOCl) es un potente antimicrobiano no antibiótico utilizado en medicina clínica para el control de infecciones y reparación de heridas. In vivo el HOCl es sintetizado por células del sistema inmune para el control del agente patógeno durante la fagocitosis y ha sido sintetizado y estabilizado en el laboratorio con potenciales aplicaciones profilácticas y terapéuticas en medicina humana. El efecto antimicrobiano, antinflamatorio y en la proliferación celular lo hacen una sustancia que debe ser más evaluada para uso clínico en otras áreas de salud. Existe un interés en el desarrollo de nuevas sustancias antimicrobianas de uso tópico en odontología para el control del biofilm dental, la inflamación gingival y para la cicatrización de heridas de la mucosa oral. Se presenta una revisión de la literatura de los principales efectos del HOCl que sustentan su investigación y uso en odontología.PALABRAS CLAVE: acido hipocloroso, HOCl, biofilm dental, cicatrización de heridas.

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Gingival bleeding on probing: relationship to change in periodontal pocket depth and effect of sodium hypochlorite oral rinse

Cited by 41 publications

References 43 publications

Multi-omics Analysis of Periodontal Pocket Microbial Communities Pre- and Posttreatment

Multi-omics Analysis of Periodontal Pocket Microbial Communities Pre- and Posttreatment

In-vitro activity of sodium-hypochlorite gel on bacteria associated with periodontitis

Ácido Hipocloroso: una Nueva Alternativa como Agente Antimicrobiano y para la Proliferación Celular para Uso en Odontología

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