Gingival Crevicular Fluid Matrix Metalloproteinase (MMP)‐7, Extracellular MMP Inducer, and Tissue Inhibitor of MMP‐1 Levels in Periodontal Disease

Emingil, Gülnur; Tervahartiala, Taina; Mäntylä, Päivi; Määttä, Marko; Sorsa, Timo; Atilla, Gül

doi:10.1902/jop.2006.060144

Cited by 54 publications

(54 citation statements)

References 62 publications

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“…Moreover, MMP-3 can activate MMP-9 via activation cascades (Sorsa et al, 1990;Ogata et al, 1992). MMP-7 degrades numerous ECM and basement membrane components (Emingil et al, 2006), activates other MMPs, including MMP-8 and MMP-9 (Kivela-Rajamaki et al, 2003), and cleaves a variety of secreted and cell-surface proteins (Wilson and Matrisian, 1996). MMP-8 plays a major role in tissue destruction and has potential as a biomarker in periodontal disease (Herr et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Cranberry Proanthocyanidins Inhibit MMP Production and Activity

Howell

Grenier

2009

J Dent Res

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Matrix metalloproteinases (MMPs) produced by resident and inflammatory cells in response to periodontopathogens play a major role in periodontal tissue destruction. Our aim was to investigate the effects of A-type cranberry proanthocyanidins (AC-PACs) on: (i) the production of various MMPs by human monocyte-derived macrophages stimulated with Aggregatibacter actinomycetemcomitans lipopolysaccharide (LPS), and (ii) the catalytic activity of recombinant MMP-1 and MMP-9. The effects of AC-PACs on the expression of 5 protein kinases and the activity of nuclear factor-kappa B (NF-kappaB) p65 in macrophages stimulated with LPS were also monitored. Our results indicated that AC-PACs inhibited the production of MMPs in a concentration-dependent manner. Furthermore, the catalytic activity of MMP-1 and MMP-9 was also inhibited. The inhibition of MMP production was associated with reduced phosphorylation of key intracellular kinases and the inhibition of NF-kappaB p65 activity. AC-PACs thus show potential for the development of novel host-modulating strategies to inhibit MMP-mediated tissue destruction during periodontitis.

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Section: Discussionmentioning

confidence: 99%

Cranberry Proanthocyanidins Inhibit MMP Production and Activity

Howell

Grenier

2009

J Dent Res

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“…It is thought that a local infection such as that occurring in periodontal disease may contribute to the establishment of a systemic inflammatory condition in genetically susceptible individuals known as ''hyperinflammatory phenotype,'' potentially involving increased production of inflammatory mediators and a breakdown of pathways responsible for immune resolution [11,14]. Recent research suggests that the ongoing inflammatory response instigated by periodontal pathogens leads to an increase in numerous markers of systemic inflammation including Creactive protein, IL-1b, IL-6, TNF-a, and Matrix Metalloprotenases [11,[15][16][17].…”

Section: Introductionmentioning

confidence: 99%

A review of the relationship between tooth loss, periodontal disease, and cancer

Meyer

Joshipura

Giovannucci

et al. 2008

Cancer Causes Control

309

226

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Recent studies have investigated the association between periodontal disease, tooth loss, and several systemic diseases including cancer, cardiovascular disease, and preterm birth. Periodontal disease, a chronic inflammatory condition, is highly prevalent in adult populations around the world, and may be preventable. Estimates of prevalence vary between races and geographic regions, with a marked increase in the occurrence of periodontal disease with advancing age. Worldwide estimates for the prevalence of severe periodontal disease generally range from 10 to 15%. The relationship between oral health and cancer has been examined for a number of specific cancer sites. Several studies have reported associations between periodontal disease or tooth loss and risk of oral, upper gastrointestinal, lung, and pancreatic cancer in different populations. In a number of studies, these associations persisted after adjustment for major risk factors, including cigarette smoking and socioeconomic status. This review provides a summary of these findings, discusses possible biological mechanisms involved, and raises methodological issues related to studying these relationships.

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“…Gulnur Emingil et al . [16] conducted a study to determine the levels of TIMP-1 in GCF samples of patients with generalized aggressive periodontitis, CP gingivitis and healthy subjects. They found increased TIMP-1 levels in GCF of generalized aggressive periodontitis compared to CP indicating that this molecule can participate in the regulation of progression of periodontal diseases.…”

Section: Discussionmentioning

confidence: 99%

Estimation of tissue inhibitor of matrix metalloproteinase-1 levels in gingival crevicular fluid in periodontal health, disease and after treatment

Reddy¹,

Anumala²,

Babu³

et al. 2014

J Indian Soc Periodontol

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Background:Initial research has shown a negative correlation between the severity of periodontal disease and tissue inhibitor of matrix metalloproteinases (TIMPs) concentrations in gingival crevicular fluid (GCF). However, there are no enough reports to correlate the TIMP-1 concentrations in GCF in periodontal health, disease and after treatment. Hence, the present study aim is to estimate the levels of TIMP-1 in GCF in periodontal health, disease and to evaluate the effect of periodontal therapy on TIMP-1 concentrations in GCF.Materials and Methods:Periodontal examination and collection of GCF by extracrevicular method was performed in 25 subjects selected randomly and categorized into three groups. Group I (Healthy, n = 10), Group II (chronic periodontitis (CP), n = 15) and Group III (After treatment group, n = 15). Scaling and root planning was performed and GCF was collected after 8 weeks of treatment. TIMP-1 levels were estimated in GCF samples by using enzyme linked immunosorbent assay.Results:TIMPs-1 was detected in all samples. Highest mean TIMP-1 concentrations in GCF were obtained for Group I, whereas the lowest concentrations were seen in Group II. This suggests that TIMP-1 levels in GCF decreases proportionally with the progression of periodontal disease and increases after treatment.Conclusion:There is a substantial decrease in the concentrations of TIMP-1 in CP patients than in healthy and after treatment individuals. Since TIMP-1 levels in GCF are negatively correlated with periodontal disease, TIMP-1 may be considered as a biomarker in periodontal disease progression. However, controlled, longitudinal studies are needed to confirm this possibility.

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Gingival Crevicular Fluid Matrix Metalloproteinase (MMP)‐7, Extracellular MMP Inducer, and Tissue Inhibitor of MMP‐1 Levels in Periodontal Disease

Cited by 54 publications

References 62 publications

Cranberry Proanthocyanidins Inhibit MMP Production and Activity

Cranberry Proanthocyanidins Inhibit MMP Production and Activity

A review of the relationship between tooth loss, periodontal disease, and cancer

Estimation of tissue inhibitor of matrix metalloproteinase-1 levels in gingival crevicular fluid in periodontal health, disease and after treatment

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