Gingival lichen planus: A clinical and pathological study

Keller, Loïc Mahé; Lombardi, Tommaso

doi:10.1016/j.jormas.2022.101354

Cited by 4 publications

(3 citation statements)

References 29 publications

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“…Lichen planus was more common in women in their 6th decade of life. This was in line with other studies (Mignogna, Russo, and Fedele 2005 ; Keller and Lombardi 2023 ). Moreover, 68.4% of these lesions presented a mixed form.…”

Section: Discussionsupporting

confidence: 93%

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Prevalence of Histopathologic Types of Gingival Lesions in the Iranian Population: A 22‐Year Retrospective Study

Shamloo,

Alam,

Khaleghi

2024

Clinical & Exp Dental Res

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ObjectivesGingiva is one of the supporting tissues around the teeth that can be affected by various neoplastic or nonneoplastic lesions. Previous studies have examined several types of gingival lesions, but the lack of a standardized classification system has hindered meaningful comparisons. Additionally, many studies focused primarily on reactive lesions. Our study aims to contribute to the understanding of gingival lesions by investigating their prevalence across age groups, genders, sites, and by their clinical presentation. This research could lead to improved diagnostic accuracy and treatment strategies.Materials and MethodsThis retrospective study explores the prevalence of gingival lesions based on biopsies during a 22‐year span. The patient's demographic details, including age, gender, and lesion's clinical presentation were systematically collected. These lesions were categorized into six groups. Descriptive statistics, χ2 test of independence, and one‐way ANOVA were used for data analysis.ResultsAmong the 7668 biopsied lesions, 684 (8.9%) lesions were located in the gingiva, with a greater occurrence in women (63.5%). Soft tissue tumors represented the most prevalent group in the gingival lesions (72.1%), and peripheral giant cell granuloma (PGCG) was the most frequent lesion (21.2%), followed by, pyogenic granuloma (19.3%), peripheral ossifying fibroma (17.8%) and focal fibrous hyperplasia (7.6%); all of which predominantly affected women, with mean ages falling in the fourth decade of life. Squamous cell carcinoma was recognized as the most common malignancy.ConclusionIn this study, PGCG was found to be the most common lesion in the gingiva in Iranian population. Further analysis using a unanimous categorization is required to confirm these results.

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Section: Discussionsupporting

confidence: 93%

“…Moreover, 68.4% of these lesions presented a mixed form. Other studies reported the same (Mignogna, Russo, and Fedele 2005 ; Keller and Lombardi 2023 ).…”

Section: Discussionsupporting

confidence: 55%

Prevalence of Histopathologic Types of Gingival Lesions in the Iranian Population: A 22‐Year Retrospective Study

Shamloo,

Alam,

Khaleghi

2024

Clinical & Exp Dental Res

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“…The global prevalence of OLP has been estimated as 1-2% [2], and OLP affects more women than men [3]. OLP lesions can be found bilaterally throughout the oral cavity and mainly involve the buccal mucosa, tongue, and gingiva [4]. In addition to the oral cavity, OLP can also present as a multisystemic disease with lesions in the genital and dermatological regions [5].…”

Section: Introductionmentioning

confidence: 99%

Non-Coding RNAs as Potential Targets for Diagnosis and Treatment of Oral Lichen Planus: A Narrative Review

Kim,

Jung

et al. 2023

Biomolecules

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Oral lichen planus (OLP) is a chronic inflammatory disease that is characterized by the infiltration of T cells into the oral mucosa, causing the apoptosis of basal keratinocytes. OLP is a multifactorial disease of unknown etiology and is not solely caused by the malfunction of a single key gene but rather by various intracellular and extracellular factors. Non-coding RNAs play a critical role in immunological homeostasis and inflammatory response and are found in all cell types and bodily fluids, and their expression is closely regulated to preserve normal physiologies. The dysregulation of non-coding RNAs may be highly implicated in the onset and progression of diverse inflammatory disorders, including OLP. This narrative review summarizes the role of non-coding RNAs in molecular and cellular changes in the oral epithelium during OLP pathogenesis.

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Peculiarities of the format of genetic blood systems in patients with oral lichen planus

Proschenko,

Zelinskaya,

Proschenko

et al. 2024

Medicni Perspektivi

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The number of patients with oral lichen planus (OLP) has increased due to the raise of aggressive forms of the disease (erosive, ulcerative and hyperkeratotic forms) with a possible risk of malignancy. There are isolated researches which indicate a genetic determinism to OLP, but more often these conclusions are based on insufficiently adequate and out of date methods, which make it impossible to correctly interpret the obtained data. The aim was to identify a genetical predisposition with a programmed risk to the oral lichen planus. The main group – 278 patients with the OLP (aged 26-65 years). The control group – 298 people (blood donors) who didn’t have dental diseases, as well as diseases of internal organs and systems. The groups were homogeneous by gender and age. In our research we used such methods: clinical, radiological, immunogenetic, statistical methods were used. The erosive form of OLP was associated with 0(I) group in 54.2±0.4% of cases, while the hyperkeratotic form was associated with group 0(I) only in 28.7±1.8% of cases. B(ІІІ) and AB(ІB) groups were less often associated with the erosive form of OLP and were observed in 17.3±0.1% and 2.0±0.1% of cases, respectively. The integration of A(ІІ) group in the erosive form of OLP was 30.5±0.1%, but the indicator was higher than in individuals with B(III) and AB(IV) groups. Hyperkeratotic form of OLP was more often observed in A(II) carriers than in 0(I) and was 44.1±0.1% versus 28.7±1.8%, respectively. With blood group B (ІІІ), the relationship with OLP is not traced. Correlative relationship with erythrocyte blood antigens of the ABO system in patients with oral lichen planus was established. Risk groups for the development of erosive and hyperkeratotic forms of lichen planus in patients with gastrointestinal tract pathology O(I)>A(II)>B(III) – with erosive form and A(II)>O(I)>B(III)) – with hyperkeratosis.

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Gingival lichen planus: A clinical and pathological study

Cited by 4 publications

References 29 publications

Prevalence of Histopathologic Types of Gingival Lesions in the Iranian Population: A 22‐Year Retrospective Study

Prevalence of Histopathologic Types of Gingival Lesions in the Iranian Population: A 22‐Year Retrospective Study

Non-Coding RNAs as Potential Targets for Diagnosis and Treatment of Oral Lichen Planus: A Narrative Review

Peculiarities of the format of genetic blood systems in patients with oral lichen planus

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