Gingival recession treatment with concentrated growth factor membrane: a comparative clinical trial

Akcan, Serap Karakış

doi:10.1590/1678-7757-2019-0236

Cited by 25 publications

(17 citation statements)

References 39 publications

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“…What is more, the VAS score of CGF group was significantly lower than control group on the 1st and 3rd day, which proved CGF could relieve postoperative pain. This result is consistent with the findings of Akcan [ 19 ], who also pointed out that platelet concentrate can improve the postoperative adverse reactions.…”

Section: Discussionsupporting

confidence: 93%

“…Collectively, CGF is a powerful biological scaffold and growth factor library [ 14 ]. CGF has been extensively used in various situations, ranging from the fifilling of extraction sockets [ 15 ] to the fifilling of a cavity after cystectomy [ 16 ], implant surgery [ 17 ], sinus augmentation procedures [ 18 ], simple GBR procedures or as a membrane support in recession coverage [ 19 ]. Further, CGF is considered to relieve postoperative pain and swelling, and reduce the occurrence of alveolar osteitis [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

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Application of concentrated growth factor to autotransplantation with inflammation in recipient area

et al. 2021

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Objective The purpose of this study was to apply concentrated growth factor (CGF) to the transplanted area with inflammation, to observe the clinical effects of CGF on the inflammation area assisted by 3D printing technology. Methods A total of 52 compromised mandibular first or second molar with chronic periapical lesions were transplanted with mature third molars. The patients were divided into CGF group (n = 26) and control group (n = 26) and transplanted into fresh extraction sockets with or without CGF. All the patients underwent clinical and radiographic examinations during the follow-up. Results Average surgery and extra-oral time were 39 min (± 7.8) and 42 s (± 10.2). The success rates of CGF group and control group were 100% and 92.3% respectively. Most of the periapical lesions in CGF group healed completely within 3 months, which was significantly faster than control group. The initial stability of CGF group was better than control group immediately after operation, and the degree of pain in CGF group was lower than control group on the 1st and 3rd day after operation. Conclusions The application of CGF in recipient site with chronic periapical lesions can accelerate the regeneration of alveolar bone and the healing of inflammation, greatly shorten the healing period. Meanwhile, CGF help to reduce postoperative pain and reaction at the early stage of healing and increase the success rate of autogenous tooth transplantation (ATT). Additionally, the use of 3D printing model can greatly reduce the extra-oral time of donor teeth.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Application of concentrated growth factor to autotransplantation with inflammation in recipient area

et al. 2021

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“…Regarding CGF, there are limited studies available in relation to periodontal regeneration. Its use has been proposed in dentistry for various situations, ranging from the filling of extraction sockets [70] to the filling of a cavity after cystectomy [71], sinus augmentation procedures [63,72,73], simple GBR procedures [74,75] or as a membrane support in recession coverage [28,[76][77][78]. It was demonstrated to possess the capacity to accelerate new bone formation [79].…”

Section: Periodontal Regenerationmentioning

confidence: 99%

“…No significant differences between the treatments were noted for recession depth, complete root coverage or mean root coverage. Connective tissue graft (CTG) is superior to CGF for enhancing keratinized tissue thickness and width during surgical root coverage procedures [76]. CGF is widely used in implant surgery.…”

Section: Periodontal Regenerationmentioning

confidence: 99%

Use of PRP, PRF and CGF in Periodontal Regeneration and Facial Rejuvenation—A Narrative Review

Mijiritsky

Assaf

Peleg

et al. 2021

Biology

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Growth factors (GFs) play a vital role in cell proliferation, migration, differentiation and angiogenesis. Autologous platelet concentrates (APCs) which contain high levels of GFs make them especially suitable for periodontal regeneration and facial rejuvenation. The main generations of APCs presented are platelet-rich plasma (PRP), platelet-rich fibrin (PRF) and concentrated growth factor (CGF) techniques. The purpose of this review is to provide the clinician with an overview of APCs’ evolution over the past decade in order to give reliable and useful information to be used in clinical work. This review summarizes the most interesting and novel articles published between 1997 and 2020. Electronic and manual searches were conducted in the following databases: Pubmed, Scopus, Cochrane Library and Embase. The following keywords were used: growth factors, VEGF, TGF-b1, PRP, PRF, CGF and periodontal regeneration and/or facial rejuvenation. A total of 73 articles were finally included. The review then addresses the uses of the three different techniques in the two disciplines, as well as the advantages and limitations of each technique. Overall, PRP is mainly used in cases of hard and soft tissue procedures, while PRF is used in gingival recession and the treatment of furcation and intrabony defects; CGF is mainly used in bone regeneration.

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“…The swelling was evaluated using the following score: 0: no swelling; 1: mild swelling; 2: moderate swelling; 3: severe swelling. 25,26 Healing index (HI)…”

Section: Pain and Swelling Scoresmentioning

confidence: 99%

Effects of Concentrated Growth Factor on Gingival Thickness in Periodontal Accelerated Osteogenic Orthodontics: A 6-Month Randomized Controlled Trial

Cao

et al. 2021

Preprint

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Background: Earlier studies have not given clear results of concentrated growth factor (CGF) on gingival thickness (GT) in periodontal accelerated osteogenic orthodontics (PAOO). This randomized controlled trial aimed to evaluate the effects of CGF on GT in patients with thin gingival phenotype undergoing PAOO.Methods: 44 patients with 264 surgical sites were recruited at baseline. All patients were randomly allocated to either a control (collagen matrix memberane) or test (CGF) group and received PAOO. GT, gingival height (GH), buccal alveolar bone thickness (BT), and buccal alveolar bone height (BH) were evaluated depending on cross-sectional CBCT images at t0 (before surgery) and t1(6 months after surgery). Results: GT were increased in both groups at t1 compared to t0. Yet, higher values were observed in the test group (from 0.95±0.26 to 1.29±0.34mm) compared to the control group (from 0.92±0.25 to 1.01±0.18mm) (p < 0.05). Moreover, in the intergroup comparison, GT at t1 in the test group was significantly higher compared to the control group (p < 0.01). Furthermore, the GT of central incisors, lateral incisors and canine teeth all showed significantly changes compared with baseline and the test group showed higher increase (p < 0.01). No statistically significant difference were found in GH, BT, BH and all clinical parameters between two groups at t1 (p > 0.05). Conclusions: Within the limitation of this study, gingival thickness could be increased by using CGF in PAOO for the patients with thin gingival phenotype. Trial registration The study was registered in Chinese Clinical Trial Registry（http://www.chictr.org.cn/index.aspx）under the number ChiCTRINR17013346, Registered 11 November 2017.

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Gingival recession treatment with concentrated growth factor membrane: a comparative clinical trial

Cited by 25 publications

References 39 publications

Application of concentrated growth factor to autotransplantation with inflammation in recipient area

Application of concentrated growth factor to autotransplantation with inflammation in recipient area

Use of PRP, PRF and CGF in Periodontal Regeneration and Facial Rejuvenation—A Narrative Review

Effects of Concentrated Growth Factor on Gingival Thickness in Periodontal Accelerated Osteogenic Orthodontics: A 6-Month Randomized Controlled Trial

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