Gingival response to a new multipurpose dental adhesive: A histologic study in dogs

Redlich, Meir; Harary, D; Shoshan, S.

doi:10.1016/s0022-3913(96)90542-9

Cited by 12 publications

(12 citation statements)

References 12 publications

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“…Similar results were found in a study regarding gingival response to dentin bonding agents, which showed that a residual agent can damage periodontal tissue. 18 The reason might be that the chemical composition of the orthodontic adhesive resins is similar to that of dental composites, pit and fissure sealants, and some direct filling resins. These materials usually contain a mixture of high-and low-molecular-weight monomers of methacrylic acid derivatives, such as BIS-GMA (an epoxy derivative of methacrylic acid) and ethyleneglycol dimethacrylate, as well as polymerization inhibitors, catalysts, and accelerators.…”

Section: Discussionmentioning

confidence: 99%

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Orthodontic Adhesives Induce Human Gingival Fibroblast Toxicity and Inflammation

Huang

Liao

et al. 2008

The Angle Orthodontist

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Objective: To test the null hypothesis that the resin base and the resin hybrid glass ionomer base adhesives do not cause inflammation after contacting primary human gingival fibroblasts in vitro. Materials and Methods:The resin base and resin hybrid glass ionomer base adhesives were used to treat human gingival fibroblasts to evaluate the survival rate using MTT colorimetric assay to detect the level of cyclooxygenase-2 (COX-2) mRNA by reverse transcription polymerase chain reaction (RT-PCR) technique and COX-2 protein expression using Western blot analysis. The results were analyzed using one-way analysis of variance (ANOVA). Tests of differences of the treatments were analyzed using the Tukey test and a value of P Ͻ .05 was considered statistically significant. Results:The paste and primer of the resin base adhesive and the liquid of glass ionomer adhesive showed decreasing survival rates after 24 hours of treatment (P Ͻ .05). All orthodontic adhesives induced COX-2 protein expression in human gingival fibroblasts. The exposure of quiescent human gingival fibroblasts to adhesives resulted in the induction of COX-2 mRNA expression. The investigations of the time-dependent COX-2 mRNA expression in adhesive-treated human gingival fibroblasts revealed different patterns. Conclusions:The hypothesis is rejected. For orthodontic patients with gingival inflammation, except for those with oral hygiene problems, the activation of COX-2 expression by orthodontic adhesive may be one of the potential mechanisms.

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Section: Discussionmentioning

confidence: 99%

“…In an animal study, adhesives may cause inflammatory reactions in the mucosa of dogs. 2 Both resin base and resin hybrid glass ionomer base adhesives can cause cytotoxicity. [3][4][5][6] In our previous study, we showed that the degree of adhesive toxicity was different according to different cell culture origins.…”

Section: Introductionmentioning

confidence: 99%

Orthodontic Adhesives Induce Human Gingival Fibroblast Toxicity and Inflammation

Huang

Liao

et al. 2008

The Angle Orthodontist

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“…As for biological characteristics, the histological observations showed at various times examined an inflammatory response in the gingiva in the case of Super Bondtreated teeth, while the H-Q-Bond Plus compositions had no noticeable effect on the gingival tissue [15].…”

Section: )mentioning

confidence: 96%

“…The biocompatibility of dental adhesive materials is a prerequisite for any dental procedure. The tolerance of gingival tissue to the H-Q-Bond Plus adhesive was tested in dogs [15]. The results from H-Q-Bond Plus were compared with those obtained from Super Bond (SB) from Sun Medical Co.,…”

Section: Shear Bond Strength (Sbs)mentioning

confidence: 99%

The role of an anaerobic accelerator in dental adhesives

Eppelbaum

Dodiuk

Kenig

et al. 1996

Journal of Adhesion Science and Technology

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A dental adhesive system was developed to yield a high bond strength to different substrates, enhanced durability, biocompatibility, and absence of interfacial microleakage. Such a system can be cured chemically (self-curing) or by visible light. Based on the assumption of an anaerobic character of the system's polymerization, the effect of the addition of an anaerobic accelerator (saccharin) on the curing mechanism was studied. Subsequently, the composition of the developed adhesive system and its curing conditions were evaluated and optimized. The developed adhesive compositions demonstrate high and durable bonding to dentin, enamel, porcelain, base and precious alloys, and amalgam, and can be used in different adhesive systems.

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“…The irritative effects of dentin bonding agents have been evaluated by histopathological examinations of the tissue responses. Unfortunately, all histological investigations demonstrated that dentin bonding agents could induce mild to severe inflammatory reactions in gingiva2, 3 as well as pulp tissue 4, 5. However, there is little information on the precise mechanisms about dentin bonding agent‐induced inflammatory reaction.…”

Section: Introductionmentioning

confidence: 99%

Induction of cyclooxygenase‐2 mRNA and protein expression by dentin bonding agents in human gingival fibroblasts

Huang

Chang

2004

J Biomed Mater Res

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An ideal dentin bonding agent should be nonirritating to surrounding tissues. Unfortunately, all histological investigations have demonstrated that dentin bonding agents can induce mild to severe inflammatory alterations. However, there is little information on the precise mechanisms about dentin bonding agents-induced inflammatory reaction. Cyclooxygenase-2 (COX-2) is an inducible enzyme believed to be responsible for prostaglandin synthesis at the site of inflammation. The aim of the present study was to investigate the effects of three dentin bonding agents, Clearfil SE Bond, Prime & Bond NT, and Single Bond on the expression of COX-2 mRNA gene and protein in cultured human gingival fibroblasts. The exposure of quiescent human gingival fibroblasts to dentin bonding agents resulted in the induction of COX-2 mRNA expression. The investigations of the time-dependent on COX-2 mRNA expression in dentin bonding agent-treated human gingival fibroblasts revealed different patterns. The influence of COX-2 mRNA depended on the tested materials. In addition, all dentin bonding agents also induced COX-2 protein expression in human gingival fibroblasts. Taken together, the activation of COX-2 expression may be one of the potential mechanisms of dentin bonding agent-induced gingival inflammation.

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Gingival response to a new multipurpose dental adhesive: A histologic study in dogs

Cited by 12 publications

References 12 publications

Orthodontic Adhesives Induce Human Gingival Fibroblast Toxicity and Inflammation

Orthodontic Adhesives Induce Human Gingival Fibroblast Toxicity and Inflammation

The role of an anaerobic accelerator in dental adhesives

Induction of cyclooxygenase‐2 mRNA and protein expression by dentin bonding agents in human gingival fibroblasts

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