Ginkgo biloba extract protects rat kidney from diabetic and hypoxic damage

Welt, K; Weiss, J.; Martin, Roderick; Hermsdorf, Thomas; Drews, Sandra; Fitzl, G.

doi:10.1016/j.phymed.2006.03.023

Cited by 50 publications

(24 citation statements)

References 18 publications

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“…All of these discoveries provide a strong pharmacological foundation for the application of GBE in diabetic nephropathy (DN) therapy. Furthermore, GBE has been ascertained to be protective against DN in vivo (Welta et al, 2007) and in cell culture (Wang et al, 2006). However, there has been scarce literature reporting on the protective effects of GBE on glomerulosclerosis in rat mesangial cells based on serum pharmacology.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Protective effects of serum containing Ginkgo biloba extract on glomerulosclerosis in rat mesangial cells

Tang

Zhang

Gao

et al. 2009

Journal of Ethnopharmacology

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Section: Introductionmentioning

confidence: 99%

RETRACTED: Protective effects of serum containing Ginkgo biloba extract on glomerulosclerosis in rat mesangial cells

Tang

Zhang

Gao

et al. 2009

Journal of Ethnopharmacology

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“…The extract of ginkgo biloba is shown to scavenge free radicals and reduce oxidative stress in animals and humans [7,8]. Protective effects of ginkgo biloba on diabetic heart, liver and kidney have been previously demonstrated [9].…”

Section: Introductionmentioning

confidence: 99%

Ginkgo biloba (EGb 761) usage attenuates testicular injury induced by testicular ischemia/reperfusion in rats

et al. 2007

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“…Diabetic nephropathy as a late complication in chronic diabetes occurs in 40% of human diabetes cases 1 . Diabetic nephropathy is characterized by the proteinuria, loss of renal function, excessive deposition of protein in extracellular matrix such as type IV collagen, overexpression of TGF-β 1 , hemodynamic changes of angiotensin II and increased glomerular permeability [2][3][4] .…”

mentioning

confidence: 99%

Antidiabetic and renoprotective effects of Corni Fructus extract in db/db mice

Kim

2010

Mol. Cell. Toxicol.

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This study investigated the effect of CorniFructus (Cornus officinalis Sieb. et Zucc.) extract on hyperglycemia, renal dysfunction and diabetic nephropathy in db/db mice. Eight weeks old male mice were divided into normal control group (NC), diabetic control group (DC) and Corni Fructus treated diabetic group (DCF). Over an 8-week experimental period, Corni Fructus extract was administered orally at 500 mg/kg BW/day. Final fasting serum glucose level in the DCF group was significantly lower than the DC group by 32% (P⁄0.05). Urine 24-h volume and urine total protein in the DCF group were significantly lower (P⁄0.05) than the DC group by 53% and 88%, respectively. The mRNA expression of angiotensin II, collagen I, collagen IV and TGF-β 1 in kidneys were significantly lower (P⁄0.05 or P⁄0.01) in the DCF group than the DC group by 39%, 42%, 38% and 26%, respectively. In histological staining of kidney tissues, collagen deposition was markedly reduced in the DCF group compared to the DC group. Immunohistochemical staining for TGF-β 1 in kidneys of the DCF group was more mildly expressed than the DC group. In conclusion, these results indicate that Corni Fructus can be effective on hyperglycemia, renal dysfunction and diabetic nephropathy in db/db mice.

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Ginkgo biloba extract protects rat kidney from diabetic and hypoxic damage

Cited by 50 publications

References 18 publications

RETRACTED: Protective effects of serum containing Ginkgo biloba extract on glomerulosclerosis in rat mesangial cells

RETRACTED: Protective effects of serum containing Ginkgo biloba extract on glomerulosclerosis in rat mesangial cells

Ginkgo biloba (EGb 761) usage attenuates testicular injury induced by testicular ischemia/reperfusion in rats

Antidiabetic and renoprotective effects of Corni Fructus extract in db/db mice

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