Ginseng and obesity

Li, Zhipeng; Ji, Geun Eog

doi:10.1016/j.jgr.2016.12.005

Cited by 94 publications

(70 citation statements)

References 95 publications

(137 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…in the present study, the GS treatment reduced the body weight gain induced by HFd and food intake was markedly reduced, indicating that the effect was caused by a reduction in calorie intake (21). The results also revealed that the treatment lowered blood glucose, serum aST, serum alT, serum TG and liver TG contents and increased the fecal excretion of TG in the mice fed a HFd, suggesting that GS effectively lower HFd-induced hyperglycemia and hyperlipidemia (57).…”

Section: Discussionsupporting

confidence: 70%

“…However, the mechanism by which GS reduces dietary intake is unknown. in a previous study, GS were revealed to exert a significant effect on reducing the food intake and weight of HFD-induced obese mice, significantly reducing serum triglycerides (TGs; P=0.03), increasing glucose tolerance, improving insulin resistance and reducing the degree of obesity in mice, compared with HFd mice (29). a further study demonstrated that GS significantly inhibited the transcriptional activity of c/eBP homologous protein (cHoP; P=0.028) and GrP7 (P=0.04) compared with HFd mice, indicating that GS reduce erS (30).…”

Section: Introductionmentioning

confidence: 94%

“…Ginsenosides (GS) [chemical abstracts Service (caS) no. 90045- are an extract from the roots, stems and leaves of ginseng (21). it is a yellow-white or light yellow amorphous powder that has a slight smelly odor and is bitter and hygroscopic (22).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Ginsenosides reduce body weight and ameliorate hepatic steatosis in high fat diet‑induced obese mice via endoplasmic reticulum stress and p‑STAT3/STAT3 signaling

Yao

2020

Mol Med Report

View full text Add to dashboard Cite

obesity has been increasing globally for over three decades. according to previous studies, dietary obesity is usually associated with endoplasmic reticulum stress (erS) and STaT3 signaling, which result in interference with the homeostatic control of energy and lipid metabolism. Ginsenosides (GS) administered to mice will modulate adiposity and food intake; however, the mechanism of food inhibition is unknown. The aim of the present study was to investigate whether GS may inhibit erS and regulate STaT3 phosphorylation in GT1-7 cells (a mouse hypothalamus gonadotropin-releasing hormone neuron cell line) and the hypothalamus in order to reduce the body weight and ameliorate hepatic steatosis in high fat diet (HFd)-induced obese mice. in the present study, GS inhibited the appetite, reduced the body weight, visceral fat, body fat content and blood glucose, and ameliorated the glucose tolerance of the obese mice compared with HFd mice. in addition, the levels of aspartate aminotransferase and alanine aminotransferase, triglyceride (TG), leptin and insulin in the serum were reduced compared with HFd mice. There was less TG in the liver, but more in the feces compared with HFd mice. using hematoxylin and eosin staining of HepG2 cells and liver tissues, GS were demonstrated to improve the non-alcoholic fatty liver of the HFd-induced obese mice and reduce the diameter of the fat cells compared with HFd mice. GS also increased oxygen consumption and carbon dioxide emissions in the metabolic cage data compared with HFd mice. in the GT1-7 cells, GS alleviated the erS induced by tunicamycin and enhanced the activation of the STaT3 phosphorylation pathway. Furthermore the erS of the liver was relieved to achieve the aforementioned pharmacological effects. GS were used in the homeostatic control of the energy and lipid metabolism of a diet-induced obesity model. in conclusion, present studies suggest that GS exert these effects by increasing STaT3 phosphorylation expression and reducing the erS. Thus, GS reduce body weight and ameliorate hepatic steatosis in HFd-induced obese mice.

show abstract

Section: Discussionsupporting

confidence: 70%

Section: Introductionmentioning

confidence: 94%

See 1 more Smart Citation

Ginsenosides reduce body weight and ameliorate hepatic steatosis in high fat diet‑induced obese mice via endoplasmic reticulum stress and p‑STAT3/STAT3 signaling

Yao

2020

Mol Med Report

View full text Add to dashboard Cite

show abstract

“…(26) Administration of 1.6% korean ginseng extract with high fat diet resulting in lower levels of mRNA associated with lipogenesis-genes suggesting that the anti-obesity effects of ginseng are due to gene regulation of lipogenesis related genes in adipose tissue and causing a delay in intestinal absorption (27). Ginseng and ginsenosides were found to regulate appetite as well as inhibit lipid synthesis and increase the level of energy consumption by skeletal muscle through activated AMPK pathway (28). Ginseng intake changes the phyla and genera of gut microbiota and weight loss was dependent on the type of microbes in the gut prior to ginseng intake (29).…”

Section: Figurementioning

confidence: 99%

A Review on the Potential Properties of Ginseng

Khurana¹

2019

IJMBS

View full text Add to dashboard Cite

Ginseng is a traditional herb mostly used in eastern world, namely the countries of Korea and China. It is believed to be a herbal elixir and useful in promotion of long healthy life. It is known to increase strength and vital capacity of the body (1). Ginsenosides are the main active compounds that constitute ginseng. They are considered to be steroidal saponins that act as anti- tumor activists (2). They have been known to show a myriad of pharmacological effects on target tissues, although the type of ginsenoside varies in each species of ginseng. This review study aims to explore the history, mechanisms, targets and effect of ginseng.

show abstract

“…In Asia, SMS is typically used in ischemic diseases mainly to treat oxidative stress and inflammation [7][8][9]. Growing evidence suggests that some of the components of SMS, ginseng and ginsenosides, inhibit adipogenesis and maintain glucose homeostasis in obese and diabetic individuals [10,11]. A polysaccharide from Ophiopogon japonicus was found to alleviate hyperlipidemia in diet-induced obese mice based on the metabolic profile of bile acids [12].…”

Section: Introductionmentioning

confidence: 99%

Shengmai San Alleviates Diabetic Cardiomyopathy Through Improvement of Mitochondrial Lipid Metabolic Disorder

Tian¹,

Tang²,

Xu³

et al. 2018

Cell Physiol Biochem

View full text Add to dashboard Cite

Background/Aims: Shengmai San (SMS), prepared from Panax ginseng, Ophiopogon japonicus, and Schisandra chinensisin, has been widely used to treat ischemic disease. In this study, we investigated whether SMS may exert a beneficial effect in diabetic cardiomyopathy through improvement of mitochondrial lipid metabolism. Methods: A leptin receptor-deficient db/db mouse model was utilized, and lean age-matched C57BLKS mice served as non-diabetic controls. Glucose and lipid profiles, myocardial structure, dimension, and function, and heart weight to tibial length ratio were determined. Myocardial ultrastructural morphology was observed with transmission electron microscopy. Protein expression and activity of oxidative phosphorylation (OXPHOS) complex were assessed using western blotting and microplate assay kits. We also observed cellular viability, mitochondrial membrane potential, OXPHOS complex activity, and cellular ATP level in palmitic acid-stimulated H9C2 cardiomyocytes. Changes in the sirtuin (SIRT1)/AMP-activated protein kinase (AMPK)/peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) pathway and mitochondrial uncoupling signaling were assessed using western blotting and quantitative real-time PCR. Results: Leptin receptor-deficient db/db mice exhibit obesity, hyperglycemia, and hyperlipidemia, accompanied by distinct myocardial hypertrophy and diastolic dysfunction. SMS at a dose of 3 g/kg body weight contributed to a recovery of diabetes-induced myocardial hypertrophy and diastolic dysfunction. SMS administration led to an effective restoration of mitochondrial structure and function both in vivo and in vitro. Furthermore, SMS markedly enhanced SIRT1 and p-AMPKα protein levels and decreased the expression of acetylated-PGC-1α and uncoupling protein 2 protein. SMS also restored the depletion of NRF1 and TFAM levels in diabetic hearts and H9C2 cardiomyocytes. Conclusion: The results indicate that SMS may alleviate diabetes-induced myocardial hypertrophy and diastolic dysfunction by improving mitochondrial lipid metabolism.

show abstract

Ginseng and obesity

Cited by 94 publications

References 95 publications

Ginsenosides reduce body weight and ameliorate hepatic steatosis in high fat diet‑induced obese mice via endoplasmic reticulum stress and p‑STAT3/STAT3 signaling

Ginsenosides reduce body weight and ameliorate hepatic steatosis in high fat diet‑induced obese mice via endoplasmic reticulum stress and p‑STAT3/STAT3 signaling

A Review on the Potential Properties of Ginseng

Shengmai San Alleviates Diabetic Cardiomyopathy Through Improvement of Mitochondrial Lipid Metabolic Disorder

Contact Info

Product

Resources

About