Ginseng treatment improves the sexual side effects of methadone maintenance treatment

Farnia, Vahid; Alikhani, Mostafa; Ebrahimi, Alireza; Golshani, Sanobar; Bahmani, Dena Sadeghi; Brand, Serge

doi:10.1016/j.psychres.2019.05.004

Cited by 20 publications

(25 citation statements)

References 49 publications

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“…American and Asian ginseng present a good safety profile with a few cases of mild gastrointestinal and sleep disorders. Psychiatric and neurological side effects are rare, and causality is difficult to ascertain [ 77 , 79 , 80 , 82 , 83 , 84 , 85 , 86 , 87 , 89 , 90 , 91 , 92 , 93 , 94 ]. In fact, most clinical studies with ginseng or ginsenosides reported no psychiatric or neurological side effects or statistically insignificant effects compared to placebo, and were not included in Table 1 [ 223 , 224 , 225 , 226 , 227 ].…”

Section: Discussionmentioning

confidence: 99%

“…A few cases of headache following ginseng administration were reported without placebo control [ 84 , 91 ]. Insomnia, agitation, and fatigue were more frequent [ 82 , 83 , 84 , 89 , 94 ], but still uncommon. More interestingly, several cases of manic-like effects, such as confusion, agitation, irritation, nervousness, anxiety, and bizarre behavior, without history of psychiatric disorder, were reported following ginseng use [ 77 , 78 , 81 , 85 , 87 , 88 , 90 , 228 ].…”

Section: Discussionmentioning

confidence: 99%

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Pharmacology of Herbal Sexual Enhancers: A Review of Psychiatric and Neurological Adverse Effects

et al. 2020

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Sexual enhancers increase sexual potency, sexual pleasure, or libido. Substances increasing libido alter the concentrations of specific neurotransmitters or sex hormones in the central nervous system. Interestingly, the same pathways are involved in the mechanisms underlying many psychiatric and neurological disorders, and adverse reactions associated with the use of aphrodisiacs are strongly expected. However, sexual enhancers of plant origin have gained popularity over recent years, as natural substances are often regarded as a safer alternative to modern medications and are easily acquired without prescription. We reviewed the psychiatric and neurological adverse effects associated with the consumption of herbal aphrodisiacs Areca catechu L., Argemone Mexicana L., Citrus aurantium L., Eurycoma longifolia Jack., Lepidium meyenii Walp., Mitragyna speciosa Korth., Panax ginseng C. A. Mey, Panax quinquefolius L., Pausinystalia johimbe (K. Schum.) Pierre ex Beille, Piper methysticum G. Forst., Ptychopetalum olacoides Benth., Sceletium tortuosum (L.) N. E. Brown, Turnera diffusa Willd. ex. Schult., Voacanga africana Stapf ex Scott-Elliot, and Withania somnifera (L.) Dunal. A literature search was conducted on the PubMed, Scopus, and Web of Science databases with the aim of identifying all the relevant articles published on the issue up to June 2020. Most of the selected sexual enhancers appeared to be safe at therapeutic doses, although mild to severe adverse effects may occur in cases of overdosing or self-medication with unstandardized products. Drug interactions are more concerning, considering that herbal aphrodisiacs are likely used together with other plant extracts and/or pharmaceuticals. However, few data are available on the side effects of several plants included in this review, and more clinical studies with controlled administrations should be conducted to address this issue.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Pharmacology of Herbal Sexual Enhancers: A Review of Psychiatric and Neurological Adverse Effects

et al. 2020

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“…Due to the difference in terms of the pathophysiology of sexual dysfunction, the treatment option of sexual dysfunction in the OST population is different from the other population. Antidepressants such as bupropion and trazodone and herbal alternatives such as rosa Damascena and ginseng have been reported to significantly improve OST patients with sexual dysfunction [8,[22][23][24][25][26][27]. Although various clinical studies and reviews have explored the role of intervention for sexual dysfunction in many conditions, such as diabetes, stroke, and cancer population, the effectiveness and safety of sexual dysfunction intervention in the OST population has not been studied thoroughly [28][29][30].…”

Section: Ivyspringmentioning

confidence: 99%

“…• Outcomes: Studies with any mean score of validated questionnaires for sexual function assessment such as Arizona Sexual Experience Scales (ASEX) [25], Brief Sexual Function Inventory [22,23], Clinical Global Impression for Sexual Function (CGI-SF) [27], Erectile Dysfunction Intensity Scale [8,26], Female Sexual Function Index [22,24], International Index of Erectile Function with 15-item [22,23,27], and Sexual Desire Inventory -2 [27]. Any minor and major adverse effects related to the interventions and the number of participants who dropped out and adverse effects were also retrieved;…”

Section: Inclusion Criteriamentioning

confidence: 99%

“…Two quasi-experimental studies had set the minimum duration of MMT at 30 days [8,26]. Other eligibility criteria included lack of the following conditions; other psychiatric comorbidities or conditions [10,[22][23][24][25], other substance use disorder [23,24,36], obvious organic illnesses [8,26,27,36], not on other psychotropic drugs [8, 22-24, 27, 36], anti-viral treatment [8,24,27], and sexual enhancement therapy [8,24,27], somatic problems [22], current marital issues [22], non-adherence to the protocol [24], allergy [22], intention to become pregnant, pregnancy, or lactation [24], and adverse effects related to treatment [24].…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

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Treatments of Sexual Dysfunction in Opioid Substitution Therapy Patients: A Systematic Review and Meta-Analysis

2021

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Sexual dysfunction is a common condition in the opioid substitution therapy (OST) population. We aimed to determine the efficacy and safety of treatment for sexual dysfunction in the OST population. We searched for interventional studies from Medline, PubMed, and Scopus. Three independent authors conducted a risk-of-bias assessment (RoB 2). A total of seven studies (five randomized-controlled trials, two quasi-experimental), including 473 patients with sexual dysfunction, were identified. Among these, three bupropion (n=207), one trazodone (n=75), two rosa Damascena (n=100), and one ginseng (n=91) studies had reported significantly improve various sexual functioning domains in both genders. In a meta-analysis, bupropion significantly increased male sexual function with standardized mean difference of 0.53; 95% confidence interval of 0.19-0.88; P < 0.01; I 2 =0. The adverse effects were minor for all agents, and no significant difference between treatment and placebo groups in randomized-controlled trials. These agents have a promising future as therapy for sexual dysfunction in the OST population. However, given the limited sample size and number of studies, further studies should be conducted to confirm the use of these agents.

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Effects of Dialectical Behavior Therapy on Emotion Regulation, Distress Tolerance, Craving, and Depression in Patients with Opioid Dependence Disorder

Rezaie¹,

Afshari

Balagabri

2021

J Contemp Psychother

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Ginseng treatment improves the sexual side effects of methadone maintenance treatment

Cited by 20 publications

References 49 publications

Pharmacology of Herbal Sexual Enhancers: A Review of Psychiatric and Neurological Adverse Effects

Pharmacology of Herbal Sexual Enhancers: A Review of Psychiatric and Neurological Adverse Effects

Treatments of Sexual Dysfunction in Opioid Substitution Therapy Patients: A Systematic Review and Meta-Analysis

Effects of Dialectical Behavior Therapy on Emotion Regulation, Distress Tolerance, Craving, and Depression in Patients with Opioid Dependence Disorder

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