Ginsenoside Re blocks Bay k-8644-induced neurotoxicity via attenuating mitochondrial dysfunction and PKCδ activation in the hippocampus of mice: Involvement of antioxidant potential

Tran, Ngoc Kim Cuong; Jeong, Ji Hoon; Sharma, Naveen; Nguyen, Yen Nhi Doan; Tran, Hoang-Yen Phi; Dang, Duy-Khanh; Park, Jung Hoon; Byun, Jae Kyung; Jin, Dongjun; Zeng, Xianying; Ko, Sung Kwon; Nah, Seung-Yeol; Kim, Hyoung‐Chun; Shin, Eun‐Joo

doi:10.1016/j.fct.2023.113869

Cited by 8 publications

(1 citation statement)

References 96 publications

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“…2 out of 15 "pro-NeuronAge" compounds were shown to be detrimental, while 2 are potentially protective. BAY-K8644 is known to be neurotoxic 54 ; and amiodarone induces neuronal apoptosis 55 and is known to induce adverse neurological effects 56 . Tacedinaline/CI-994 is a class I histone deacetylase inhibitor correlates positively with NeuronAge, was shown to promote functional recovery following spinal cord injury 57 , and to enhance synaptic and structural neuroplasticity 58 .…”

Section: Identi Cation Of Drugs Preserving Neuronal Functionmentioning

confidence: 99%

Neuron-type specific aging-rate reveals age decelerating interventions preventing neurodegeneration

Schumacher,

Gallrein,

Meyer

2024

Preprint

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Different types of neurons show distinct susceptibility to age-dependent functional decline and degeneration and are linked to different types of neurodegenerative disorders. The underlying reasons for different aging trajectories of distinct neuron types are poorly understood. Here, we employ aging clocks to assess whether distinct neurons differ in their biological age trajectory in C. elegans where the identity of each single neuron is known. We find that specifically ciliated sensory neurons with high neuropeptide expression show the most rapidly progressing biological age. The more rapidly aging neurons show a reduction of mitochondrial respiration and elevated protein translation gene expression. Reducing protein translation with cycloheximide effectively protected fast aging neurons. We show that the C. elegans neuronal aging pattern are highly correlated with human brain aging and contrasted by geroprotective interventions. We performed an in silico drug screen and identified known and novel neuroprotective small molecule compounds. We show that the natural occurring plant metabolite syringic acid and the piperazine derivative vanoxerine delay neuronal degeneration and propose that they could serve as neuroprotective interventions. We also identify neurotoxins that accelerate neurodegeneration indicating that this approach could reveal interventions as well as risk factors for neuronal aging.

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Section: Identi Cation Of Drugs Preserving Neuronal Functionmentioning

confidence: 99%

Neuron-type specific aging-rate reveals age decelerating interventions preventing neurodegeneration

Schumacher,

Gallrein,

Meyer

2024

Preprint

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Neuroprotection and mechanisms of ginsenosides in nervous system diseases: Progress and perspectives

Zhou,

Tan,

Zhang

et al. 2024

IUBMB Life

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Ginsenosides are the primary component discernible from ginseng, including Rb1, Rb2, Rd, Rg1, Rg2, and compound K, and so forth. They have been shown to have multiple pharmacological activities. In recent years, more and more studies have been devoted to the neuroprotection of various ginsenosides against neurological diseases and their potential mechanisms. This paper comprehensively summarizes and reviews the neuroprotective effects of various ginsenosides on neurological diseases, especially acute and chronic neurodegenerative diseases, and their mechanisms, as well as their potential therapeutic applications to promote neuroprotection in disease prevention, treatment, and prognosis. Briefly, ginsenosides exert effective neuroprotective effects on neurological conditions, including stroke, Alzheimer's disease, Parkinson's disease, and brain/spinal cord injuries through a variety of molecular mechanisms, including anti‐inflammatory, antioxidant, and anti‐apoptotic. Among them, some signaling pathways play important roles in related processes, such as PI3K/Akt, TLR4/NF‐κB, ROS/TXNIP/NLRP3, HO‐1/Nrf2, Wnt/β‐catenin, and Ca2+ pathway. In conclusion, the present study reviews the research progress on the neuroprotective effects of ginsenosides in the last decade, with the aim of furnishing essential theoretical underpinning and effective references for further research and exploration of the multiple medicinal values of Chinese herbal medicines and their small molecule compounds, including ginseng and panax ginseng. Because there is less evidence in the existing clinical studies, future research should be focused on clinical trials in order to truly reflect the clinical value of various ginsenosides for the benefit of patients.

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Traditional Chinese medicines treat ischemic stroke and their main bioactive constituents and mechanisms

Fan,

Liu,

Liu

et al. 2023

Phytotherapy Research

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Ischemic stroke (IS) remains one of the leading causes of death and disability in humans. Unfortunately, none of the treatments effectively provide functional benefits to patients with IS, although many do so by targeting different aspects of the ischemic cascade response. The advantages of traditional Chinese medicine (TCM) in preventing and treating IS are obvious in terms of early treatment and global coordination. The efficacy of TCM and its bioactive constituents has been scientifically proven over the past decades. Based on clinical trials, this article provides a review of commonly used TCM patent medicines and herbal decoctions indicated for IS. In addition, this paper also reviews the mechanisms of bioactive constituents in TCM for the treatment of IS in recent years, both domestically and internationally. A comprehensive review of preclinical and clinical studies will hopefully provide new ideas to address the threat of IS.

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Ginsenoside Re blocks Bay k-8644-induced neurotoxicity via attenuating mitochondrial dysfunction and PKCδ activation in the hippocampus of mice: Involvement of antioxidant potential

Cited by 8 publications

References 96 publications

Neuron-type specific aging-rate reveals age decelerating interventions preventing neurodegeneration

Neuron-type specific aging-rate reveals age decelerating interventions preventing neurodegeneration

Neuroprotection and mechanisms of ginsenosides in nervous system diseases: Progress and perspectives

Traditional Chinese medicines treat ischemic stroke and their main bioactive constituents and mechanisms

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