Ginsenoside Re enhances small-conductance Ca2+-activated K+ current in human coronary artery endothelial cells

Sukrittanon, Suporn; Watanapa, Wattana B.; Ruamyod, Katesirin

doi:10.1016/j.lfs.2014.09.007

Cited by 11 publications

(8 citation statements)

References 37 publications

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“…A study on human umbilical vein endothelial cells (HUVECs) revealed that Re augmented [Ca 2+ ] i and NO production in a dose-dependent manner (EC 50 of 316 and 615 nM, respectively) ( Leung et al, 2007 ). In human coronary artery endothelial cells, Re (1 μM) induced vasorelaxation by increasing small-conductance Ca 2+ -activated K + (SK Ca ) channel activity, stimulating NO production, and promoting vasodilation ( Sukrittanon et al, 2014 ).…”

Section: Pharmacological Effects Of Re On Cardiovascular Diseases (Cvds)mentioning

confidence: 99%

Pharmacological Properties of Ginsenoside Re

et al. 2022

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Ginsenoside Re is a protopanaxatriol-type saponin extracted from the berry, leaf, stem, flower bud, and root of Panax ginseng. In recent years, ginsenoside Re (Re) has been attracting attention as a dietary phytochemical. In this review, studies on Re were compiled by searching a combination of keywords, namely “pharmacology,” “pharmacokinetics,” and “toxicology,” in the Google Scholar, NCBI, PubMed, and Web of Science databases. The aim of this review was to provide an exhaustive overview of the pharmacological activities, pharmacokinetics, and toxicity of Re, focusing on clinical evidence that has shown effectiveness in specific diseases, such as diabetes mellitus, nervous system diseases, inflammation, cardiovascular disease, and cancer. Re is also known to eliminate virus, enhance the immune response, improve osteoporosis, improve skin barrier function, enhance intracellular anti-oxidant actions, regulate cholesterol metabolism, alleviate allergic responses, increase sperm motility, reduce erectile dysfunction, promote cyclic growth of hair follicles, and reduce gastrointestinal motility dysfunction. Furthermore, this review provides data on pharmacokinetic parameters and toxicological factors to examine the safety profile of Re. Such data will provide a theoretical basis and reference for Re-related studies and future applications.

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Section: Pharmacological Effects Of Re On Cardiovascular Diseases (Cvds)mentioning

confidence: 99%

Pharmacological Properties of Ginsenoside Re

et al. 2022

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“…Ginseng is well known in China and other countries for its therapeutic effects on cardiovascular diseases (Sukrittanon, Watanapa, & Ruamyod, ), cerebrovascular diseases (Bak etal. , ), endocrine system diseases (Shishtar etal.…”

Section: Introductionmentioning

confidence: 99%

“…Ginseng is well known in China and other countries for its therapeutic effects on cardiovascular diseases (Sukrittanon, Watanapa, & Ruamyod, 2014), cerebrovascular diseases (Bak et al, 2015), endocrine system diseases (Shishtar et al, 2014), inflammation (Lee et al, 2015) and cancer (Wang et al, 2015), etc. Ginsenosides are known to be the main efficacious compounds of ginseng.…”

Section: Introductionmentioning

confidence: 99%

Development and validation of an UPLC‐Q/TOF‐MS assay for the quantitation of neopanaxadiol in beagle dog plasma: Application to a pharmacokinetic study

Geng

Wang

et al. 2016

Biomedical Chromatography

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Neopanaxadiol (NPD), the main panaxadiol constituent of Panax ginseng C. A. Meyer (Araliaceae), has been regarded as the active component for the treatment of Alzheimer's disease. However, few references are available about pharmacokinetic evaluation for NPD. Accordingly, a rapid and sensitive method for quantitative analysis of NPD in beagle dog plasma based on ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry was developed and validated. Analytes were extracted from plasma by liquid-liquid extraction and chromatographic separation was achieved on an Agilent Zorbax Stable Bond C column. Detection was performed in the positive ion mode using multiple reaction monitoring of the transitions both at m/z 461.4 → 425.4 for NPD and internal standard of panaxadiol. All validation parameters, such as lower limit of quantitation, linearity, specificity, precision, accuracy, extraction recovery, matrix effect and stability, were within acceptable ranges and the method was appropriate for multitude sample determination. After oral intake, NPD was slowly absorbed and eliminated from circulatory blood system and corresponding plasma exposure was low. Application of this quantitative method will yield the first pharmacokinetic profile after oral administration of NPD to beagle dog. The information obtained here will be useful to understand the pharmacological effects of NPD.

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“…Among the three types of blood vessels, arteries are the blood vessels that originate from the ventricles and the largest and thickest blood vessels (Dimitrievska & Niklason, 2018; Kakisis, Liapis, Breuer, & Sumpio, 2005). Injuries of arterial endothelial cells and smooth muscle cells may cause vasoconstriction, leading to the occurrence of cardiovascular diseases (Figure 1a) (Fang et al, 2011; Persson, Dong, & Persson, 2006; Sukrittanon, Watanapa, & Ruamyod, 2014). Vein vessels have fewer smooth muscle cells and endothelial cells than arteries, and their walls are thinner.…”

Section: Blood Vessels and Vascular Dysfunctionmentioning

confidence: 99%

Ginseng in vascular dysfunction: A review of therapeutic potentials and molecular mechanisms

Zhang

Xue

et al. 2022

Phytotherapy Research

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Vascular dysfunction can lead to a variety of fatal diseases, including cardiovascular and cerebrovascular diseases, metabolic syndrome, and cancer. Although a large number of studies have reported the therapeutic effects of natural compounds on vascular-related diseases, ginseng is still the focus of research. Ginseng and its active substances have bioactive effects against different diseases with vascular dysfunction. In this review, we summarized the key molecular mechanisms and signaling pathways of ginseng, its different active ingredients or formula in the prevention and treatment of vascular-related diseases, including cardiac-cerebral vascular diseases, hypertension, diabetes complications, and cancer. Moreover, the bidirectional roles of ginseng in promoting or inhibiting angiogenesis have been highlighted. We systematically teased out the relationship between ginseng and vascular dysfunction, which could provide a basis for the clinical application of ginseng in the future.

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Ginsenoside Re enhances small-conductance Ca2+-activated K+ current in human coronary artery endothelial cells

Cited by 11 publications

References 37 publications

Pharmacological Properties of Ginsenoside Re

Pharmacological Properties of Ginsenoside Re

Development and validation of an UPLC‐Q/TOF‐MS assay for the quantitation of neopanaxadiol in beagle dog plasma: Application to a pharmacokinetic study

Ginseng in vascular dysfunction: A review of therapeutic potentials and molecular mechanisms

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