Ginsenoside Rg5 improves cognitive dysfunction and beta-amyloid deposition in STZ-induced memory impaired rats via attenuating neuroinflammatory responses

Chu, Shenghui; Gu, Junfei; Feng, Liang; Liu, Jiping; Zhang, Minghua; Jia, Xiao‐Bin; Liu, Min; Da-nian, Yao

doi:10.1016/j.intimp.2014.01.018

Cited by 111 publications

(69 citation statements)

References 48 publications

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“…In the current study, the expression levels of COX-2 were observed to be significantly up-regulated in STZ-induced AD mice and down-regulated strongly by gingerol compared with that in control mice. Similarly, it was previously demonstrated that the STZ-induced learning and memory impairments in mice are due to stimulation of the neuro-inflammatory response 31 .…”

Section: Discussionmentioning

confidence: 75%

RETRACTED ARTICLE: Protective effects of gingerol on streptozotocin-induced sporadic Alzheimer’s disease: emphasis on inhibition of β-amyloid, COX-2, alpha-, beta - secretases and APH1a

El-Halawany

Sayed

Abdallah

et al. 2017

Sci Rep

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Gingerol is a major dietary compound that occurs in several plants belonging to the Zingiberaceae family. In the current study, the protective effect of gingerol on STZ-induced sporadic Alzheimer’s disease (SAD) was determined. Gingerol was isolated from the seeds of Aframomum melegueta K. Schum and tested at doses of 10 and 20 mg/kgbwt for its possible effect on the SAD model in mice, using celecoxib (30 mg/kg bwt) as a reference standard. The curative effects of gingerol were assessed through measurement of β-amyloid (Aβ-42), α-, β- secretases, APH1a and COX-2 levels. In addition, improvement in the cognitive deficit in mice after treatment was confirmed using the water maze and Y-maze with intra-maze cues. Gingerol improved the cognitive and behavioral impairment and AD-like pathology in streptozotocin model mice. These beneficial effects occurred with an increase in α-secretase activity and a decrease in cerebral Aβ-42, β- secretase, APH1a activity and COX-2-linked neuro-inflammation.

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Section: Discussionmentioning

confidence: 75%

RETRACTED ARTICLE: Protective effects of gingerol on streptozotocin-induced sporadic Alzheimer’s disease: emphasis on inhibition of β-amyloid, COX-2, alpha-, beta - secretases and APH1a

El-Halawany

Sayed

Abdallah

et al. 2017

Sci Rep

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“…The principal bioactive components of ginseng are ginsenosides (e.g., ginsenosides Rg1, Rg3, and Rg5), which have been suggested to have antioxidant, anti-inflammatory, and antiapoptotic effects [49]. In addition, ginsenoside Rg5 has been shown to reduce amyloid- β and cholinesterase activity [50], while ginsenoside Rg3 has also been shown to promote β -amyloid peptide degradation via enhancing gene expression [51–54]. In addition, research demonstrates that Panax ginseng decreases blood pressure and improves blood circulation via vasodilation activities [55].…”

Section: Individual Herbs Used In Vadmentioning

confidence: 99%

Herbal Medicine for the Treatment of Vascular Dementia: An Overview of Scientific Evidence

Chang

Liu

Bilinski

et al. 2016

Evidence-Based Complementary and Alternative Medicine

115

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Dementia is a leading cause of mental and physical disability. Vascular dementia (VaD) is the second most common cause of dementia after Alzheimer's disease (AD) constituting 10–15% of the dementia population. Currently there are no approved pharmaceutical options for VaD and the conventional anti-AD therapies provide only modest, short-term relief of symptoms associated with VaD. Herbal medicines have been used for the management of dementia-like symptoms for centuries and may provide viable therapies for VaD due to their multicomponent and multitarget approach. This review is designed to provide an updated overview on the current status of herbal medicine research, with an emphasis on Chinese herbal medicine, for the treatment of VaD or dementia. A case study is also provided to demonstrate the development process of a novel standardized complex herbal formulation for VaD. The article reveals some preliminary evidence to support the use of single and complex herbal preparations for VaD and dementia. Multiple issues in relation to clinical and preclinical research have been identified and future research directions are discussed.

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“…Ginsenoside Rg5 has been shown to improve cognitive dysfunction and neuroinflammation and modulate both AChE and ChAT activity in brain cortex [72]. Other ginsenosides, Re and Rd, are also shown to enhance ChAT and vascular acetylcholine transporter (VAChT) to increase the Ach level in neuro-21 cells [73].…”

Section: Effects On the Central Nervous Systemmentioning

confidence: 99%

A Role of Ginseng and Its Constituents in the Treatment of Central Nervous System Disorders

Rokot

Kairupan

Cheng

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Ginseng, a perennial plant belonging to the Panax genus of the Araliaceae family, has been used in China, Korea, and Japan as a traditional herbal medicine for thousands of years. Ginseng is recorded to have exhibited a wide variety of beneficial pharmacological effects and has become a popular and worldwide known health supplement and drug. The protective effects of ginseng on central nervous system are discussed in this review. Ginseng species and ginsenosides and their intestinal metabolism and bioavailability are concisely introduced. The molecular mechanisms of the effects of ginseng on central nervous system, mainly focused on the neuroprotection properties of ginseng, memory, and learning enhanced properties, and the effects on neurodegenerative disorders are presented. Thus, ginseng and its constituents are of potential merits in the treatment of cerebral disorders.

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Ginsenoside Rg5 improves cognitive dysfunction and beta-amyloid deposition in STZ-induced memory impaired rats via attenuating neuroinflammatory responses

Cited by 111 publications

References 48 publications

RETRACTED ARTICLE: Protective effects of gingerol on streptozotocin-induced sporadic Alzheimer’s disease: emphasis on inhibition of β-amyloid, COX-2, alpha-, beta - secretases and APH1a

RETRACTED ARTICLE: Protective effects of gingerol on streptozotocin-induced sporadic Alzheimer’s disease: emphasis on inhibition of β-amyloid, COX-2, alpha-, beta - secretases and APH1a

Herbal Medicine for the Treatment of Vascular Dementia: An Overview of Scientific Evidence

A Role of Ginseng and Its Constituents in the Treatment of Central Nervous System Disorders

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