The current research study aims to introduce the experience of implementing a serious game using the concept of game-based GIS approach for crisis management during earthquake disasters. In this study, we aimed to develop a game-based GIS approach and examine its efficiency for simulating earthquake rescue management in Tabriz city. In designing this game, typical scenario-based, game-based GIS methods and techniques were employed, and the proposed approach was applied to crisis management. To achieve this goal, we addressed the technical details regarding the development and implementation of the scenario-based and game-based GIS approach. Based on the results, game-based simulations can be considered an efficient approach for disaster simulation and can improve the skills of rescue teams. The outcome of this application is an intellectual game that almost all users at any age can play, and the game can challenge their ability to solve critical issues. The results are critical for explaining the effectiveness of rescue teams and crisis management facilities. As we intended to develop an approach for the simulation of earthquake disasters and emergency responses, we therefore conclude that the results of this study can also be employed to improve the skills of rescue teams and citizens for dealing with crises resulting from earthquake disasters. As a result of this research, the developed tool is published, together with this paper, as an open source and can be employed for any scenario-based analysis in other case studies. By presenting a-state-of-the-art approach, the results of this research study can provide significant contribution to further the development of GIScience and its applications for disaster and risk mitigation and management.