The aim of the study is to evaluate the effectiveness of local therapy of gonarthrosis with blood autoserum in terms of the patient`s life quality and pain syndrome dynamics. The roentgenograms and the questionnaire data of 22 patients with gonarthrosis I-IV before and after treatment were analyzed by SF-36 questionnaire, Lequen index, Likert and visual analog scales. The patients after the treatment revealed a statistically significant increase in the physical functioning rate, lower pain syndrome according to Lequen index, Likert and visual analogue scale. The results of the study confirm the effectiveness of medical technology of blood autoserum intraarticular injection in the patients with gonathrosis of I-III stages.