GL-V9 reverses adriamycin resistance in hepatocellular carcinoma cells by affecting JNK2-related autophagy

Yang, Yue; Liao, Yan; Gui, Yanping; Zhao, Li; Guo, Lu-Bo

doi:10.1016/s1875-5364(20)30059-5

Cited by 10 publications

(7 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, many drugs for HCC still have toxic side effects, which limit their usage in the clinic ( Cheung et al., 2007 ; Sak, 2012 ; Chen et al., 2020 ; Zingales et al., 2020 ), and drug resistance of HCC hampers the treatment effects ( Xiong et al. ; Folmer et al., 2007 ; Tan et al., 2019 ; Li et al., 2020 ; Xu et al., 2020 ; Yang et al., 2020 ). Hence, it is urgent to discover new curative compounds with less adverse effects to treat this disease.…”

Section: Introductionmentioning

confidence: 99%

An Integrative Serum Pharmacology-Based Approach to Study the Anti-Tumor Activity of B. paniculatum Aqueous Bulb Extract on the Human Hepatocellular Carcinoma Cell Line BEL-7404

Feng

Shi

et al. 2020

Front. Pharmacol.

View full text Add to dashboard Cite

The herb Bolbostemma paniculatum (Maxim) Franquet (Cucurbitaceae family), also known as Tu-Bei-Mu (TBM) in Chinese, has shown curative effects to treat several types of cancer as an adjunctive therapy. Thereby we intend to find its effect on the human hepatocellular carcinoma (HCC) and to understand the pharmacological mechanism behind it. In this study, an integrative serum pharmacology-based approach linking serum pharmacology and bioinformatics prediction was employed. Firstly, we used the serum taken introgastrically from the rats dministered by TBM aqueous bulb extract to culture the HCC cell line BEL-7404 and detect its anti-tumor effects. Secondly, the TBM putative targets were predicted using the ETCM database and known therapeutic targets of NPC were collected from the OMIM database. Then, a TBM-HCC putative targets network was constructed using the DAVID and STRING databases. Thirdly, key gene targets were obtained based on topological analysis and pathway enrichment analysis. The expression of 4 representative key targets were validated by Western blotting. As a result, 36 TBM targets and 26 known therapeutic targets of HCC were identified. These key targets were found to be frequently involved in 13 KEGG pathways and 4 biological processes. The expression of four representative key targets: TP53, CASP3, BCL2 and BAX further supports the suppression of TBM on HCC. In general, our study shows the curative effects of TBM against HCC. By using this integrative approach, we may find novel potential therapeutic targets to suppress HCC using TBM as an adjunctive therapy. And it could also help us understand the mechanism of HCC treatments in response to TBM.

show abstract

Section: Introductionmentioning

confidence: 99%

An Integrative Serum Pharmacology-Based Approach to Study the Anti-Tumor Activity of B. paniculatum Aqueous Bulb Extract on the Human Hepatocellular Carcinoma Cell Line BEL-7404

Feng

Shi

et al. 2020

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…Sterodial saponins increase LC3-II and p62 levels, indicating their role in impairing autophagy flux and reducing tumor growth [251] Quercetin Akt/mTOR Quercetin inhibits Akt/mTOR axis to induce autophagy and mediate apoptosis [252] Propyl gallate -Increasing the conversion of LC3-I to LC3-II and triggering autophagy in reducing HCC progression [253] Lycorine TCPR1/Akt/mTOR Lycorine suppresses the TCPR1/Akt/mTOR axis in triggering autophagy and apoptosis [254] Exenatide mTOR Exenatide suppresses the mTOR pathway in triggering apoptosis and autophagy [255] Astragaloside ABT-737 Beclin-1 ABT-737 induces autophagy via ROS and upregulation of Beclin-1 Pro-survival function of autophagy [261] 3-methyladenine -Inhibition of autophagy in enhancing sorafenib sensitivity of cancer cells [262] Cardiac glycosides AMPK Autophagy induction by AMPK upregulation Autophagy inhibition increases capacity for apoptosis induction [263] Morin hydrate PARP1/HMGB1 Morin hydrate suppresses PARP1/HMGB1 axis in autophagy inhibition and suppresses cisplatin resistance [264] Chloroquine -Chloroquine suppresses autophagy and prevents mitochondrial dysfunction in promoting chemosensitivity [265] GL-V9 JNK2 GL-V9 suppresses autophagy via downregulation of JNK2 in reversing adriamycin resistance [266]…”

Section: Sterodial Saponins Lc3-ii P62mentioning

confidence: 99%

Targeting and regulation of autophagy in hepatocellular carcinoma: revisiting the molecular interactions and mechanisms for new therapy approaches

et al. 2023

View full text Add to dashboard Cite

Autophagy is an evolutionarily conserved process that plays a role in regulating homeostasis under physiological conditions. However, dysregulation of autophagy is observed in the development of human diseases, especially cancer. Autophagy has reciprocal functions in cancer and may be responsible for either survival or death. Hepatocellular carcinoma (HCC) is one of the most lethal and common malignancies of the liver, and smoking, infection, and alcohol consumption can lead to its development. Genetic mutations and alterations in molecular processes can exacerbate the progression of HCC. The function of autophagy in HCC is controversial and may be both tumor suppressive and tumor promoting. Activation of autophagy may affect apoptosis in HCC and is a regulator of proliferation and glucose metabolism. Induction of autophagy may promote tumor metastasis via induction of EMT. In addition, autophagy is a regulator of stem cell formation in HCC, and pro-survival autophagy leads to cancer cell resistance to chemotherapy and radiotherapy. Targeting autophagy impairs growth and metastasis in HCC and improves tumor cell response to therapy. Of note, a large number of signaling pathways such as STAT3, Wnt, miRNAs, lncRNAs, and circRNAs regulate autophagy in HCC. Moreover, regulation of autophagy (induction or inhibition) by antitumor agents could be suggested for effective treatment of HCC. In this paper, we comprehensively review the role and mechanisms of autophagy in HCC and discuss the potential benefit of targeting this process in the treatment of the cancer. Graphical abstract

show abstract

“…GL-V9 (5-hydroxy-8-methoxy-2-phenyl-7-(4-(pyrrolidine-1-yl) butoxy)4 H-chromen-4-one) is a new synthesized flavonoid derivative. GL-V9 induces autophagy by activating AMPK, thereby blocking NLRP3 inflammasome activation, and exhibits therapeutic potential in liver cancer model ( 167 , 168 ). A recent study has shown that GL-V9 had a significant anti-inflammatory effect in a colorectal cancer model associated with colitis.…”

Section: Treatment Strategymentioning

confidence: 99%

NLRP3 inflammasome in digestive diseases: From mechanism to therapy

Qiang

Dai

et al. 2022

Front. Immunol.

View full text Add to dashboard Cite

Digestive system diseases remain a formidable challenge to human health. NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome is the most characteristic multimeric protein complex and is involved in a wide range of digestive diseases as intracellular innate immune sensors. It has emerged as a research hotspot in recent years. In this context, we provide a comprehensive review of NLRP3 inflammasome priming and activation in the pathogenesis of digestive diseases, including clinical and preclinical studies. Moreover, the scientific evidence of small‐molecule chemical drugs, biologics, and phytochemicals, which acts on different steps of the NLRP3 inflammasome, is reviewed. Above all, deep interrogation of the NLRP3 inflammasome is a better insight of the pathomechanism of digestive diseases. We believe that the NLRP3 inflammasome will hold promise as a novel valuable target and research direction for treating digestive disorders.

show abstract

GL-V9 reverses adriamycin resistance in hepatocellular carcinoma cells by affecting JNK2-related autophagy

Cited by 10 publications

References 22 publications

An Integrative Serum Pharmacology-Based Approach to Study the Anti-Tumor Activity of B. paniculatum Aqueous Bulb Extract on the Human Hepatocellular Carcinoma Cell Line BEL-7404

An Integrative Serum Pharmacology-Based Approach to Study the Anti-Tumor Activity of B. paniculatum Aqueous Bulb Extract on the Human Hepatocellular Carcinoma Cell Line BEL-7404

Targeting and regulation of autophagy in hepatocellular carcinoma: revisiting the molecular interactions and mechanisms for new therapy approaches

NLRP3 inflammasome in digestive diseases: From mechanism to therapy

Contact Info

Product

Resources

About