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Шемеровский, Константин Александрович

doi:10.1023/a:1022965212971

Cited by 10 publications

(5 citation statements)

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“…Defection is an overt indication of colonic motility that shows daily rhythmicity, peaking in the active period. This has been reported in numerous species, including diurnal humans ( Rendtorff and Kashgarian, 1967 ; Heaton et al, 1992 ; Aschoff, 1994 ; Shemerovskii, 2002 ) and non-human primates ( Bernstein, 1964 ; Caton et al, 1996 ), birds ( Clarke, 1979 ; Rodriguez-Sinovas et al, 1994 ; Malek et al, 2020 ), dogs ( Hirabayashi et al, 2009 ), horses ( Piccione et al, 2005 ), camels ( Aubè et al, 2017 ), and sheep ( Piccione et al, 2005 ); and nocturnal rodents ( Gosling, 1979 ; Magot and Chevallier, 1983 ; Firpo et al, 2005 ; Hoogerwerf et al, 2010 ; de Azevedo et al, 2011 ; Platt et al, 2013 ; Allen and Johnson, 2018 ), foxes ( Klenk, 1971 ), antechinus ( Cowan et al, 1974 ), rabbit ( Jilge, 1974 ; Jilge and Hudson, 2001 ), hare ( Pehrson, 1983 ), and house musk ( Kobayashi et al, 2022 ). Some species, such as degu and the Mongolian gerbil that can show either diurnal or nocturnal activity patterns ( Refinetti, 2006 ) have a more constant defecation pattern ( Kenagy et al, 1999 ).…”

Section: Introductionmentioning

confidence: 53%

Circadian rhythms in colonic function

Hibberd,

Ramsay,

Spencer-Merris

et al. 2023

Front. Physiol.

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A rhythmic expression of clock genes occurs within the cells of multiple organs and tissues throughout the body, termed “peripheral clocks.” Peripheral clocks are subject to entrainment by a multitude of factors, many of which are directly or indirectly controlled by the light-entrainable clock located in the suprachiasmatic nucleus of the hypothalamus. Peripheral clocks occur in the gastrointestinal tract, notably the epithelia whose functions include regulation of absorption, permeability, and secretion of hormones; and in the myenteric plexus, which is the intrinsic neural network principally responsible for the coordination of muscular activity in the gut. This review focuses on the physiological circadian variation of major colonic functions and their entraining mechanisms, including colonic motility, absorption, hormone secretion, permeability, and pain signalling. Pathophysiological states such as irritable bowel syndrome and ulcerative colitis and their interactions with circadian rhythmicity are also described. Finally, the classic circadian hormone melatonin is discussed, which is expressed in the gut in greater quantities than the pineal gland, and whose exogenous use has been of therapeutic interest in treating colonic pathophysiological states, including those exacerbated by chronic circadian disruption.

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Section: Introductionmentioning

confidence: 53%

Circadian rhythms in colonic function

Hibberd,

Ramsay,

Spencer-Merris

et al. 2023

Front. Physiol.

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“…Patients with chronic slow transit constipation have significantly reduced colonic pressure activity after waking up or food intake compared to healthy individuals [33]. A study by Shemerovskii et al found that healthy individuals have daily bowel movements in the morning between 6 am and noon, while those with irregular bowel habits have daily bowel movements only three to four times a week, predominantly between 8 pm and midnight [34]. Hence, the human colon has been naturally programmed to empty in the morning after awakening, and this biorhythm can potentially be altered by VC to achieve beneficial treatment effects in patients with chronic constipation [35].…”

Section: Discussionmentioning

confidence: 99%

Vibrating colon-stimulating capsule to treat chronic constipation: A systematic review

Ravi,

Math,

Hakami

et al. 2023

JMedLife

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In August 2022, the United States Food and Drug Administration issued marketing authorization for an orally administered vibrating colon-stimulating capsule for treating chronic idiopathic constipation. We aimed to review the literature systematically and synthesize evidence on the role of the vibrating capsule in chronic idiopathic constipation. A comprehensive search was conducted on PubMed, Embase, International Clinical Trials Registry Platform (World Health Organization), Cochrane Library databases, and two pre-print servers (medRxiv.org and Research Square) until 31 December 2022, to identify published pre-clinical and clinical original studies evaluating the role of the vibrating capsule in patients with chronic constipation. The studies were critically analyzed, and data were extracted. We identified thirty-three articles and five studies (one pre-clinical, one combined, and three clinical). The pre-clinical studies in dogs revealed no adverse effects of the vibrating capsule. In the clinical studies, there were significant findings observed. The number of spontaneous bowel movements per week and the proportion of patients experiencing an increase of at least one complete spontaneous bowel movement per week were both significantly higher in the group receiving the vibrating capsule compared to the group receiving the sham capsule. No treatment-related serious adverse event was noted. The mild adverse events were vibration sensation, diarrhea, and abdominal discomfort. The efficacy and safety profiles of the vibrating colon-stimulating capsule in treating patients with chronic constipation are promising. However, more robust evidence is required by conducting large randomized clinical trials before conclusively determining its wider use.

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“…Методом «Хроноэнтерографии» [4][5][6] обследовано 356 волонтёров (студенты-медики в возрасте 19-22 лет, 242 женщины). Кроме того, обследован 2501 медицинский работник в возрасте от 24 до 75 лет, 76% женщины с помощью анкетирования -1-страничный тест «Ритмы и здоровье».…”

Section: методика исследованияunclassified

Colorectal bradyarrhythmia syndrome as a predictor of metabolic syndrome

Шемеровский¹,

Федорец²,

Селиверстов³

et al. 2020

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Evidence is presented for a signiﬁcantly wider spread of the ﬁrst two stages (mild and moderate) Colorectal Bradyarrhythmia Syndrome (CBS) compared with the third (severe — constipation) stage of this syndrome. Surveyed more than 2,500 medical professionals by the method of chronoenterographia. It was found that the incidence of mild CBS (about 60% of cases) and moderate stage of this syndrome (about 30% of cases) is almost an order of magnitude higher than the incidence of severe stage (about 10% of cases) of CBS. SCB has been shown to increase the risk of obesity by almost 3 times. It is shown that CBS contributes to a decrease in well-being, activity and mood, as well as a decrease in the quality of life. Screening for CBS and normalizing the circadian bowel rhythm with psyllium (mucofalc) in individuals who consider themselves healthy may contribute to early prevention of the risk of the metabolic syndrome.

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Cited by 10 publications

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Circadian rhythms in colonic function

Circadian rhythms in colonic function

Vibrating colon-stimulating capsule to treat chronic constipation: A systematic review

Colorectal bradyarrhythmia syndrome as a predictor of metabolic syndrome

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