Glabridin Protects Paraoxonase 1 from Linoleic Acid Hydroperoxide Inhibition via Specific Interaction: A Fluorescence-Quenching Study

Atrahimovich, Dana; Vaya, Jacob; Tavori, Hagai; Khatib, Soliman

doi:10.1021/jf2046009

Cited by 45 publications

(44 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In Recently, Atrahymovic and colleagues showed that the isoflavan glabridin could link re-PON1, 368 despite the high hydrophobic subunit, protecting re-PON1 in a dose-dependent (1−100 μM) 369 manner [125]. The authors hypothesized that the mechanism governing the protective effect was 370 not related to the antioxidant action, but rather to a physical interaction with the enzyme.…”

Section: Hypothesized Mechanisms Of Pon1 Regulation Trough Polyphenolmentioning

confidence: 99%

Role of polyphenols and polyphenol-rich foods in the modulation of PON1 activity and expression

Martini

Bò

Porrini

et al. 2017

The Journal of Nutritional Biochemistry

View full text Add to dashboard Cite

27Paraxonase 1 (PON1) is a HDL-associated enzyme involved in the protection of LDL and HDL-28 lipoproteins against lipid peroxidation. Several studies documented the capacity of polyphenols 29 to stimulate PON1 transcription activation. 30The objective of the present review is to provide the main evidence about the role and the 31 potential mechaninsm of action of polyphenols and polyphenol-rich foods in the modulation of 32 PON1 gene expression and activity. 33A total of 76 in vitro and in vivo studies were included in the review. Overall, while evidence 34 obtained in vitro are limited to quercetin and resveratrol, those deriving from animal models 35 seem more convincing for a wide range of polyphenols but only at pharmacological doses. 36Evidence from human studies are promising but deserve more substantiation about the role of 37 polyphenol-rich foods in the regulation of PON1 activity and expression. 38Research focused on the understanding of the structure-activity relathionship of polyphenols 39 with PON1 and on the mechanisms at the base of PON1-modulation is warranted. designed human intervention studies are encourage to corroborate the findings of polyphenols 41 also at physiological doses. 63Several studies support the hypothesis that a low paraxonase and lactonase activity of 64 PON1 has been associated with an increased oxidative stress and vulnerability to plaque 65 formation, atherosclerosis and cardiovascular diseases [1,[4][5][6][7][8][9] that polyphenols effects may be mediated also by the regulation of PON1 activity and gene 96 expression. In the present review, we attempt to summarize the main evidence on the potential 97 effects of polyphenols and polyphenol-rich foods on PON1 expression and activity also 98 considering, when available, the contribution of genetic factors and the mechanisms of action. 99The review will focus on both in vitro and in vivo studies. 100 2.OVERVIEW OF IN VITRO AND IN VIVO STUDIES ON POLYPHENOLS AS 101 MODULATORS OF PON1 EXPRESSION AND ACTIVITY 102A systematic search for literature focused on the effect of polyphenols and polyphenol-rich found the optimal induction of intracellular and extracellular PON1 activity within 2-20 μM of 141 resveratrol while no effect was observed at doses higher than 20 μM, which in turn resulted 142 cytotoxic leading to a decrease of cell metabolic activity. 143Three studies found a dose-dependent in increase of PON1 activity [42,45,46] Animal studies 167The effect of polyphenols and polyphenol-rich foods on animal models has been evaluated in 44 168 studies (see Supplementary Table 2 under "Supplemental data" in the online issue) 169 [25,39,40,42,43,. Most of them were performed on mice or rats, while two studies on 170 hamsters [62,74]. The main polyphenols tested were quercetin [43,52,54,58,63,68,71,87] [25,53,56,57,69,70,78,85,87]. Other studies provided only an estimation 176 of the polyphenol content evaluated through indirect techniques, for example measuring the total 177 phenolic content by the Folin-Ciocalt...

show abstract

Section: Hypothesized Mechanisms Of Pon1 Regulation Trough Polyphenolmentioning

confidence: 99%

Role of polyphenols and polyphenol-rich foods in the modulation of PON1 activity and expression

Martini

Bò

Porrini

et al. 2017

The Journal of Nutritional Biochemistry

View full text Add to dashboard Cite

show abstract

“…Its activity is inhibited through an oxidation process initiated by the lipid fraction of the human carotide plaque or by linoleic acid hydroperoxide [79]. Hatrahimovich et al [81] demonstrated that Glab specifically interacted with the enzyme and consequently reduced or prevented its inhibition by linoleic acid hydroperoxide.…”

Section: Reported Biological Activitiesmentioning

confidence: 99%

Phytochemistry and biological properties of glabridin

Simmler¹,

Pauli²,

Chen³

2013

Fitoterapia

223

150

View full text Add to dashboard Cite

Glabridin, a prenylated isoflavonoid of G. glabra L. roots (European licorice, Fabaceae), has been associated with a wide range of biological properties such as antioxidant, anti-inflammatory, anti-atherogenic, regulation of energy metabolism, estrogenic, neuroprotective, anti-osteoporotic, skin-whitening. While glabridin is one of the most studied licorice flavonoids, a comprehensive literature survey linked to its numerous bioactivities is unavailable. The present review provides a comprehensive description of glabridin as a key chemical and biological marker of G. glabra, by covering both its phytochemical characterization and reported biological activities. Both glabridin and standardized licorice extracts have significant impact on food, dietary supplements (DSs) and cosmetic markets, as evidenced by the amount of available patents and scientific articles since 1976, when glabridin was first described. Nevertheless, a thorough literature survey also reveals that information about the isolation and chemical characterization of this important marker is scattered and less detailed than expected. Accordingly, the first part of this review gathers all analytical and spectroscopic data required for the comprehensive phytochemical characterization of glabridin. The four most frequently described and most relevant bioactivities of glabridin are its anti-inflammatory, anti-atherogenic, estrogenic-like effects, and its capacity to regulate energy metabolism. While all bioactivities reported for glabridin belong to a wide array of targets, its principal biological properties are likely interconnected. To this end, the current state of the literature suggests that the biological activity of glabridin mainly results from its capacity to down-regulate intracellular reactive oxygen species, bind to antioxidant effectors, and act on estrogen receptors, potentially as a plant-based Selective Estrogen Receptor Modulator (phytoSERM).

show abstract

“…As already mentioned, the fluorescence quenching mechanisms usually involve either static or dynamic quenching [32]. The quenching rate constant decreases with the increasing Table 1, respectively.…”

Section: Analysis Of Fluorescence Quenching Of Hsa By Dm Enantiomersmentioning

confidence: 83%

Multispectroscopic and molecular modeling approach to investigate the interaction of diclofop-methyl enantiomers with human serum albumin

Zhang¹,

Liu²,

Li³

et al. 2014

Journal of Luminescence

View full text Add to dashboard Cite

Glabridin Protects Paraoxonase 1 from Linoleic Acid Hydroperoxide Inhibition via Specific Interaction: A Fluorescence-Quenching Study

Cited by 45 publications

References 42 publications

Role of polyphenols and polyphenol-rich foods in the modulation of PON1 activity and expression

Role of polyphenols and polyphenol-rich foods in the modulation of PON1 activity and expression

Phytochemistry and biological properties of glabridin

Multispectroscopic and molecular modeling approach to investigate the interaction of diclofop-methyl enantiomers with human serum albumin

Contact Info

Product

Resources

About