Gland Attenuation, a Novel Morphological Feature of Colorectal Cancer: Evidence for an Epithelial-Mesenchymal Transition

Baek, Tae-Hwa; Kang, Dong-Wook; Kim, Jooheon; Son, Hyun-Jin

doi:10.3393/ac.2017.12.02

Cited by 4 publications

(2 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…EMT is recognized to be important in cancer cell migration/metastasis. For example, to metastasize, disseminated mesenchyme-like tumor cells of well-differentiated carcinomas must regain their epithelial function (invasion and metastasis) [ 28 , 29 ]. The disruption of epithelial-cell homeostasis leading to aggressive cancer progression is correlated with the loss of epithelial characteristics and the acquisition of a migratory phenotype, known to EMT, and is considered to be a crucial event in malignancy [ 30 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of a Novel Epithelial–Mesenchymal Transition Gene Signature Predicting Survival in Patients With HNSCC

Wei¹,

Zhao²,

Jiang³

et al. 2021

Pathol. Oncol. Res.

View full text Add to dashboard Cite

Head and neck squamous cell cancer (HNSCC) is one of the most common types of cancer worldwide. There have been many reports suggesting that biomarkers explored via database mining plays a critical role in predicting HNSCC prognosis. However, a single biomarker for prognostic analysis is not adequate. Additionally, there is growing evidence indicating that gene signature could be a better choice for HNSCC prognosis. We performed a comprehensive analysis of mRNA expression profiles using clinical information of HNSCC patients from The Cancer Genome Atlas (TCGA). Gene Set Enrichment Analysis (GSEA) was performed, and we found that a set of genes involved in epithelial mesenchymal transition (EMT) contributed to HNSCC. Cox proportional regression model was used to identify a four-gene (WIPF1, PPIB, BASP1, PLOD2) signature that were significantly associated with overall survival (OS), and all the four genes were significantly upregulated in tumor tissues. We successfully classified the patients with HNSCC into high-risk and low-risk groups, where in high-risk indicated poorer patient prognosis, indicating that this gene signature might be a novel potential biomarker for the prognosis of HNSCC. The prognostic ability of the gene signature was further validated in an independent cohort from the Gene Expression Omnibus (GEO) database. In conclusion, we identified a four-EMT-based gene signature which provides the potentiality to serve as novel independent biomarkers for predicting survival in HNSCC patients, as well as a new possibility for individualized treatment of HNSCC.

show abstract

Section: Discussionmentioning

confidence: 99%

Identification of a Novel Epithelial–Mesenchymal Transition Gene Signature Predicting Survival in Patients With HNSCC

Wei¹,

Zhao²,

Jiang³

et al. 2021

Pathol. Oncol. Res.

View full text Add to dashboard Cite

show abstract

“…Existing evidence has revealed that FUT8 serves as a regulator in EMT through catalysing glycosylation. EMT is a process of epithelial cells converting into motile mesenchymal cells, which contributes pathologically to cancer migration, invasion and metastasis . Cell–cell adhesion mediated by E‐cadherin was strengthened with the reduction of core fucosylation, suggesting that blockade of FUT8‐mediated glycosylation can maintain cancer cell–cell connection.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA‐198‐5p inhibits the migration and invasion of non‐small lung cancer cells by targeting fucosyltransferase 8

Wang

Zhang

Yang

et al. 2019

Clin Exp Pharma Physio

View full text Add to dashboard Cite

Lung cancer is a leading cause of high mortality among cancer patients. According to different histomorphological features, lung cancer is divided into two categories, non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC), which account for about 85% and 15% of total lung cancers, respectively. Further, NSCLC can be divided into squamous cell carcinoma, adenocarcinoma and large cell carcinoma. 1 Lung cancer is often misdiagnosed as tuberculosis due to their common symptoms and patients with lung cancer have a 5-year survival rate of only 18.1%. 2,3 Various diagnostic techniques like CT-imaging, bronchoscopy and sputum cytology and main treatments like surgical resection, radiotherapy and chemotherapy have been recently modified for better sensitivity and accuracy, but the outcomes are still not ideal due to the metastasis of lung cancer. Therefore, it is necessary to explore the key factors and the molecular mechanisms involved in lung cancer metastasis for the development of diagnostic and therapeutic strategies.The invasion and migration of lung cancer cells are closely related to the abnormal glycosylation. Fucosyltransferase 8 (FUT8), α1,6 fucosyltransferase, catalyses the transfer of fucose residues on GDP-fucose to the N-ligand oligosaccharides of glycoproteins linked Abstract displays crucial roles in various cancers including non-small cell lung cancer (NSCLC), but the underlying molecular mechanisms remain unclear. Fucosyltransferase 8 (FUT8) is associated with tumour metastasis and prognosis. In this study, we explored the expression of miR-198-5p and FUT8 in NSCLC patients. Results showed that miR-198-5p was under-expressed in NSCLC tissues and was negatively correlated with tumour size, lymph node metastasis and tumour-node-metastasis stage, while FUT8 expression was highly upregulated.Next, we altered miR-198-5p expression using the mimic or inhibitor in the functional study. Results showed that miR-198-5p overexpression could inhibit the migration, invasion and epithelial-to-mesenchymal transition (EMT) of NSCLC cells; reversely, suppression of miR-198-5p enhanced cell migration, invasion and EMT. In vivo, miR-198-5p overexpression inhibited the formation of mouse lung and liver metastasis.Luciferase reporter, real-time PCR and western blot assays showed that miR-198-5p could directly target FUT8 and regulate FUT8 expression. Further, FUT8 overexpression reversed the effect of miR-198-5p overexpression on the migration, invasion and EMT of NSCLC cells. Taken together, miR-198-5p functions as a tumour suppressor by targeting FUT8 in NSCLC. MiR-198-5p may be developed as a new diagnostic biomarker and therapeutic target for lung cancer. K E Y W O R D Sepithelial-to-mesenchymal transition, fucosyltransferase 8, invasion, microRNA-198-5p, migration, non-small cell lung cancer

show abstract

Prognostic impact of microscopic vessel invasion and visceral pleural invasion and their correlations with epithelial–mesenchymal transition, cancer stemness, and treatment failure in lung adenocarcinoma

et al. 2019

View full text Add to dashboard Cite

Gland Attenuation, a Novel Morphological Feature of Colorectal Cancer: Evidence for an Epithelial-Mesenchymal Transition

Cited by 4 publications

References 37 publications

Identification of a Novel Epithelial–Mesenchymal Transition Gene Signature Predicting Survival in Patients With HNSCC

Identification of a Novel Epithelial–Mesenchymal Transition Gene Signature Predicting Survival in Patients With HNSCC

MicroRNA‐198‐5p inhibits the migration and invasion of non‐small lung cancer cells by targeting fucosyltransferase 8

Prognostic impact of microscopic vessel invasion and visceral pleural invasion and their correlations with epithelial–mesenchymal transition, cancer stemness, and treatment failure in lung adenocarcinoma

Contact Info

Product

Resources

About