Glandular odontogenic cyst: analysis of cytokeratin expression and clinicopathological features

Semba, Ichiro; Kitano, Motoo; Mimura, Tamotsu; Sonoda, Satoru; Miyawaki, Akihiko

doi:10.1111/j.1600-0714.1994.tb00079.x

Cited by 42 publications

(11 citation statements)

References 28 publications

(19 reference statements)

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“…Immunohistochemical studies using cytokeratin-7, 13, 14 and 19 and their positivity strongly support the odontogenic nature of GOC [32]. The identification of osteodentin [27] and negative reaction for EMA [33] in the area of glandular structures suggest that these features are not of glandular origin and support the concept of odontogenic differentiation in GOC.…”

Section: Discussionmentioning

confidence: 71%

Glandular Odontogenic Cyst: Report of Two Cases and Review of Literature

Anuthama

Sherlin

Ramalingam

et al. 2009

Head and Neck Pathol

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Glandular odontogenic cyst (GOC) is an uncommon jaw bone cyst of odontogenic origin described in 1987 by Gardner et al. It is a cyst having an unpredictable and potentially aggressive behaviour. It also has the propensity to grow to a large size and tendency to recur with only 111 cases having been reported thus far. The first case occurred in a 42-year-old female and presented as a localized swelling extending from 19 to 29 regions. There was a history of traumatic injury at the site. There was evidence of bicortical expansion and radiographs revealed a multilocular radiolucency. The second case occurred in a 21-year-old male, as a large swelling in the mandible and radiograph revealed radiolucency in the region. On histopathological examination, these lesions were diagnosed as GOC. It was concluded that, two cases submitted by us correlate with the existing literature that GOC’s affect more commonly in the middle age group, having predilection for mandible and that trauma could be a precipitating factor for its occurrence. The increased recurrence rates can be due to its intrinsic biological behavior, multilocularity of the cyst, and incomplete removal of the lining following conservative treatment.

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Section: Discussionmentioning

confidence: 71%

Glandular Odontogenic Cyst: Report of Two Cases and Review of Literature

Anuthama

Sherlin

Ramalingam

et al. 2009

Head and Neck Pathol

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“…[9] The immunohistochemical examination performed by Semba et al . [11] for expression of cytokeratins and epithelial membrane antigen suggested that the lining of the epithelium was of odontogenic origin with metaplastic mucous-laden cells.…”

Section: Discussionmentioning

confidence: 99%

Glandular odontogenic cyst mimicking central mucoepidermoid carcinoma

Prabhu

Rekha

Kumar

2010

J Oral Maxillofac Pathol

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Glandular odontogenic cyst (GOC) is a rare developmental cyst of the jaws. The most common site of occurrence is the anterior mandible, and it is most commonly seen in middle-aged people. It is a destructive lesion with a high rate of recurrence. A predilection for men is observed. Clinical and radiographic findings are not specific, and it can mimic as any other destructive lesion of the jaw. The histopathological features of GOC and those of low-grade central mucoepidermoid carcinoma (MEC) are similar. Often, they are misdiagnosed as MEC. We present a case of GOC in the posterior maxilla, which is a rare site. The similarities and differences between GOC and central MEC are also discussed.

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“…Various treatment modality for GOC ranging from curettage, enucleation to en bloc , partial ostectomy have been recommended (1, 2, 5–20, 24, 30). In the present series, nine lesions were first treated by conservative treatment, Extirpation with segmental ostectomy of maxilla/partial mandibulectomy were in remaining three cases.…”

Section: Discussionmentioning

confidence: 99%