Glassy cell carcinoma of the cervix: A bimodal treatment strategy

Lotocki, Robert; Krepart, Garry V.; Paraskevas, M; Vadas, G.; Heywood, M.; Fung, Michael Fung Kee

doi:10.1016/0090-8258(92)90052-k

Cited by 39 publications

(48 citation statements)

References 9 publications

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“…[2][3][4] In our study the incidence (0.2%) was by far the lowest of all as com- pared to previous studies. Even though there are debates about whether GCC is a distinct clinicopathologic entity and separate histologic subtype, it is necessary to know the cytologic features of GCC because this tumor has not only unique cytologic findings but also diagnostic pitfalls, leading to occasional underdiagnosis.…”

Section: Discussionsupporting

confidence: 72%

“…2 This tumor has been known to occur in younger women than does usual cervical carcinoma. 2,6,7 Those clinical characteristics result in complications of treatment-aggressive therapy and secondary ovarian failure in relatively young women. Early detection may rescue those patients from disaster, and it cannot be overemphasized that cervical cytologic screening has made a great contribution to early detection of cervical cancer.…”

mentioning

confidence: 99%

mentioning

confidence: 99%

“…2,3,5,6 A combination of radical surgery and radiotherapy was proposed for GCC considering its aggressive biologic behavior. 2 This tumor has been known to occur in younger women than does usual cervical carcinoma. 2,6,7 Those clinical characteristics result in complications of treatment-aggressive therapy and secondary ovarian failure in relatively young women.…”

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confidence: 99%

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Glassy Cell Carcinoma of the Uterine Cervix

Chung¹,

Koh²,

Lee³

et al. 2000

Acta Cytologica

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Section: Discussionsupporting

confidence: 72%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Glassy Cell Carcinoma of the Uterine Cervix

Chung¹,

Koh²,

Lee³

et al. 2000

Acta Cytologica

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“…This finding corroborates previous studies that demonstrated that GCC accounts for 1%-2% of all cervical malignancies [1,2,4,8,9,12,15,[17][18][19]. Although ArabBedouins make up nearly 20% of the population in southern Israel, not even a single case of cervical GCC was encountered among Arab-Bedouin women during the entire 39 years of the study period.…”

Section: Discussionsupporting

confidence: 93%

Glassy cell carcinoma of the uterine cervix

Piura

Rabinovich

Meirovitz

et al. 1999

Journal of Surgical Oncology

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Background and Objectives Glassy cell carcinoma (GCC) of the uterine cervix is a rare and highly malignant tumor, accounting for only 1%–2% of all cervical carcinomas. The purpose of this study was to investigate the clinical findings, treatment, and outcome of patients with cervical GCC in the south of Israel. Methods Data from the files of 5 patients with cervical GCC who were managed at the Soroka Medical Center, Beer‐Sheva, Israel, between January 1961 and June 1999 were evaluated. Results Age at diagnosis ranged from 32 to 84 years, with 1 patient pregnant at the time of diagnosis. Vaginal bleeding was the prevailing presenting symptom. The cervical lesion was exophytic in 4 patients and endophytic (“barrel‐shaped”) in 1 patient. Mean tumor size was 3.9 cm. Three patients with stage IB1 disease had radical hysterectomy and bilateral pelvic lymph node dissection followed by either external pelvic radiotherapy or brachytherapy or both. All 3 patients were alive without disease 4, 12, and 18 months after initial diagnosis, respectively. One patient with stage IIIB disease had external pelvic radiotherapy alone and died of disease 12 months after initial diagnosis. One patient with stage IVB disease refused treatment and died of disease 3 months after initial diagnosis. Conclusions Cervical GCC is a rare variant of cervical cancer with distinct histologic features and an alleged aggressive clinical behavior. For early‐stage disease, the treatment of choice seems to be radical surgery followed by chemoradiotherapy. J. Surg. Oncol. 1999;72:206–210. © 1999 Wiley‐Liss, Inc.

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Special problems in cervical cancer management

Nguyen¹,

Averette

1999

Semin. Surg. Oncol.

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Cervical cancer is easily recognized when it presents as a visible lesion, but a problem arises when it adopts unusual presentations. Cervical cancer can develop high in the endocervical canal, beyond the reach of cone biopsy. Copious vaginal discharge from cervical adenocarcinoma may lead to a false‐negative Papanicolaou (Pap) smear. Treatment of cervicitis can result in a delay in diagnosis. Successful and timely diagnosis and treatment of cervical cancer requires experience and vigilance. Careful intraoperative palpation of the cervix and uterus can help determine the location and extent of the lesion. Flexibility during surgery is required to utilize intraoperative findings and thus optimize treatment. Pitfalls of cervical cancer diagnosis and treatment with actual case presentations are presented along with other special problems in cervical cancer management such as incidental findings of cervical cancer in hysterectomy specimens, treatment of cervical stump cancers, and unusual cervical cancer cell types. Semin. Surg. Oncol. 16:261–266, 1999. © 1999 Wiley‐Liss, Inc.

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Glassy cell carcinoma of the cervix: A bimodal treatment strategy

Cited by 39 publications

References 9 publications

Glassy Cell Carcinoma of the Uterine Cervix

Glassy Cell Carcinoma of the Uterine Cervix

Glassy cell carcinoma of the uterine cervix

Special problems in cervical cancer management

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