Glassy cell carcinoma of the uterine cervix

Abstract

Background and Objectives Glassy cell carcinoma (GCC) of the uterine cervix is a rare and highly malignant tumor, accounting for only 1%–2% of all cervical carcinomas. The purpose of this study was to investigate the clinical findings, treatment, and outcome of patients with cervical GCC in the south of Israel. Methods Data from the files of 5 patients with cervical GCC who were managed at the Soroka Medical Center, Beer‐Sheva, Israel, between January 1961 and June 1999 were evaluated. Results Age at diagnosis ranged from 32 to 84 years, with 1 patient pregnant at the time of diagnosis. Vaginal bleeding was the prevailing presenting symptom. The cervical lesion was exophytic in 4 patients and endophytic (“barrel‐shaped”) in 1 patient. Mean tumor size was 3.9 cm. Three patients with stage IB1 disease had radical hysterectomy and bilateral pelvic lymph node dissection followed by either external pelvic radiotherapy or brachytherapy or both. All 3 patients were alive without disease 4, 12, and 18 months after initial diagnosis, respectively. One patient with stage IIIB disease had external pelvic radiotherapy alone and died of disease 12 months after initial diagnosis. One patient with stage IVB disease refused treatment and died of disease 3 months after initial diagnosis. Conclusions Cervical GCC is a rare variant of cervical cancer with distinct histologic features and an alleged aggressive clinical behavior. For early‐stage disease, the treatment of choice seems to be radical surgery followed by chemoradiotherapy. J. Surg. Oncol. 1999;72:206–210. © 1999 Wiley‐Liss, Inc.

Adjuvant combined paclitaxel and carboplatin chemotherapy for glassy cell carcinoma of the uterine cervix: Report of three cases with clinicopathological analysis

“…Glassy cell carcinoma of the uterine cervix (GCC) is pathologically characterized by a moderate amount of pale granular cytoplasm, centrally located nuclei with prominent nucleoli, distinct cell membranes and prominent eosinophil infiltration of the stroma 1–4 …”

“…Glassy cell carcinoma of the uterine cervix (GCC) is pathologically characterized by a moderate amount of pale granular cytoplasm, centrally located nuclei with prominent nucleoli, distinct cell membranes and prominent eosinophil infiltration of the stroma. [1][2][3][4] In the majority of previous reports, the clinical behavior of GCC is characterized by aggressiveness, rapid progression, early metastases, and poor outcome. Further, the survival rate of GCC of stage I or II was reported to be <50%.…”

“…It has traditionally been classified as the most poorly differentiated adenosquamous carcinoma of the uterine cervix. The clinical behavior of GCC is characterized by aggressiveness, rapid progression, early metastases, and poor response to conventional radiation and surgical modes of treating cervical carcinoma 2–4 . However, it has been reported that GCC appears to have a better prognosis than previously reported 5 .…”

“…The clinical behavior of GCC is characterized by aggressiveness, rapid progression, early metastases, and poor response to conventional radiation and surgical modes of treating cervical carcinoma. [2][3][4] However, it has been reported that GCC appears to have a better prognosis than previously reported. 5 As yet, prognostic factors and effective adjuvant therapy have not been established.…”

Multimodal treatment for glassy cell carcinoma of the uterine cervix

“…Glassy cell carcinoma (GCC) of the uterine cervix is a rare form of cervical cancer, accounting for only 1–5% of all cervical cancer cases 1–5 . It has traditionally been classified as the most poorly differentiated form of adenosquamous carcinoma of the uterine cervix 1,6 .…”